Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti
Kathleen F. Walsh, Stalz Charles Vilbrun, Ariadne Souroutzidis, Sobieskye Delva, Guy Joissaint, L Mathurin, Oksana Ocheretina, Pierre Y. Crémieux, et al. (10 authors)
Clinical Infectious Diseases · 2019-01
Abstract
We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.
MeSH terms
- Isoniazid
- Medicine
- Tuberculosis
- Culture conversion
- Cohort
- Multiple drug resistance
- Internal medicine
- Drug resistance