Potential drug-drug interactions between antiretroviral therapy and treatment regimens for multi-drug resistant tuberculosis: Implications for HIV care of MDR-TB co-infected individuals
Mukonzo J, Aklillu E, Marconi V, Schinazi RF
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2019-04
Abstract
HIV-positive TB co-infected patients are at increased risk of multidrug-resistant (MDR)-TB compared to HIV-negative patients. Co-treatment of MDR-TB and HIV is common particularly in Sub-Saharan Africa where the co-morbidity is endemic. We discuss potential cellular metabolic pathway-mediated drug-drug interactions and the possible effect on HIV treatment outcomes of commonly prescribed antiretroviral therapy.
MeSH terms
- Humans
- Tuberculosis, Multidrug-Resistant
- HIV Infections
- Antitubercular Agents
- Anti-HIV Agents
- Treatment Outcome
- Drug Interactions
- Adult
- Coinfection