Improved Outcomes With High-dose Isoniazid in Multidrug-resistant Tuberculosis Treatment in Haiti
Walsh KF, Vilbrun SC, Souroutzidis A, Delva S, Joissaint G, Mathurin L, Ocheretina O, Cremieux P, et al. (10 authors)
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019-08
Abstract
We report outcomes for a cohort of patients with multidrug-resistant tuberculosis who received high-dose isoniazid in Haiti. Patients who received high-dose isoniazid had a faster time to culture conversion and higher odds of successful outcome, despite high-level isoniazid resistance. This suggests high-dose isoniazid may have effectiveness even with phenotypic resistance.
MeSH terms
- Humans
- Tuberculosis, Multidrug-Resistant
- Isoniazid
- Antitubercular Agents
- Treatment Outcome
- Retrospective Studies
- Adult
- Haiti
- Female
- Male
- Young Adult