TB Research

Development of new drug-regimens against multidrug-resistant tuberculosis

Vasava MS, Nair SG, Rathwa SK, Patel DB, Patel HD

The Indian journal of tuberculosis · 2018-07

Abstract

Tuberculosis (TB) being the leading infectious killer in the domain wherein globally, almost 20% of all TB strains are resistant to at least 1 major TB drug and there's a growing incidence of multi-drug resistance tuberculosis (MDR-TB). Looking at the current scenario and challenges the existing strategies fall back in terms of treatment of TB. So, to overcome this new, stronger, improved TB drug pipeline and a new standard for the development of novel anti-TB drugs are required in order to make more drug-resistant and efficient drug which also lower the duration period of the treatment of the TB. This review article aims to highlight the recent developments in the anti-tuberculosis agents, those are currently in the clinical development stage.

MeSH terms

  • Humans
  • Tuberculosis, Multidrug-Resistant
  • Ethylenediamines
  • Ethambutol
  • Isoniazid
  • Adamantane
  • Macrolides
  • Nitroimidazoles
  • Oxazolidinones
  • Pyrazinamide
  • Rifampin
  • Antitubercular Agents
  • Drug Therapy, Combination
  • Medication Adherence
  • Diarylquinolines
  • Drug Development
  • Duration of Therapy