Development of new drug-regimens against multidrug-resistant tuberculosis
Vasava MS, Nair SG, Rathwa SK, Patel DB, Patel HD
The Indian journal of tuberculosis · 2018-07
Abstract
Tuberculosis (TB) being the leading infectious killer in the domain wherein globally, almost 20% of all TB strains are resistant to at least 1 major TB drug and there's a growing incidence of multi-drug resistance tuberculosis (MDR-TB). Looking at the current scenario and challenges the existing strategies fall back in terms of treatment of TB. So, to overcome this new, stronger, improved TB drug pipeline and a new standard for the development of novel anti-TB drugs are required in order to make more drug-resistant and efficient drug which also lower the duration period of the treatment of the TB. This review article aims to highlight the recent developments in the anti-tuberculosis agents, those are currently in the clinical development stage.
MeSH terms
- Humans
- Tuberculosis, Multidrug-Resistant
- Ethylenediamines
- Ethambutol
- Isoniazid
- Adamantane
- Macrolides
- Nitroimidazoles
- Oxazolidinones
- Pyrazinamide
- Rifampin
- Antitubercular Agents
- Drug Therapy, Combination
- Medication Adherence
- Diarylquinolines
- Drug Development
- Duration of Therapy