Showing 1–25 of 25 documents
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L. Parolina, Olga Otpuschennykova, Natalia Kazimirova, N. P. Doktorovа
The aim of this study is to identify the most significant social determinants and co-morbidities of patients with extensively drug resistant tuberculosis (XDR-TB). <b>Methods:</b> Case-control analysis of treatment outcomes among 67 patients with XDR and 122 drug sensitive (DS) T…
World Health Organization. Regional Office for South-East Asia
…ize Herbalnet. Reducing health inequities through action on social determinants of health (WHA62.14) Action by Member States (1) Build political commitment to reduce health inequity by addressing social determinants of health; (2) mainstream health equity in all policies to achie…
Thembile Zini, Lindiwe Modest Faye, Monwabisi Faleni
…ol, with success rates below global targets. While clinical determinants such as resistance type are well established, the role of social and behavioral factors is less clearly defined. This study examined both clinical and socioeconomic predictors of DR-TB outcomes in the Easter…
Gabriela Gallego Valera, Gabriela Vilasbôas Navarro, Luana Louise Goulart Zanchin, Suelen Limieri Machado Santilli, Iris Ricardo Rossin
…ent adherence. Airborne transmission, latent infection, and social determinants, especially in vulnerable groups such as older adults and immunocompromised individuals, worsen disease control. In Brazil, the situation was further compromised during the COVID-19 pandemic, negative…
Parissa Farnia, Ali Akbar Velayati, Jalaledin Ghanavi, Poopak Farnia
…st in low- and middle-income countries, where socioeconomic determinants such as poverty, malnutrition, overcrowded living conditions, and limited access to quality healthcare exacerbate disease transmission and worsen outcomes. The emergence and spread of drug-resistant TB, incl…
Sonia Islam Khan
…, inadequate healthcare infrastructure, and patient-related social determinants. Multidrug-resistant TB (MDR-TB) and extensively drug-resistant TB (XDR-TB) have emerged as major threats to global TB control, requiring longer, more toxic, and costlier treatment courses with variab…
Majani Edward, Ameh Wisdom Owoicho
…g-resistant TB (MDR-TB and XDR-TB), the pervasive impact of social stigma on care-seeking and adherence, and the long-term disruptions caused by the COVID-19 pandemic on TB services. To overcome these multifaceted obstacles, we propose strategic directions for future research and…
Roseli Monteiro da Silva, Afrânio L. Kristki, Bernardo Pereira Cabral, Martha Maria Oliveira
…logies and strategies for the elimination of TB in light of social determinants of health models and forecasting studies. We conclude by suggesting that the expected emerging technologies ongoing development will not suffice to end TB by 2050.
Naidu T, Pillay SR, Ramlall S, Mthembu SS, Padayatchi N, et al.
Stigma is an important social determinant of health-seeking behavior; however, the nature and extent of its association with depression among people living with multidrug-resistant tuberculosis (MDR-TB) are not well-understood. We enrolled 200 microbiologically confirmed MDR-TB i…
European Centre for Disease Prevention and Control, World Health Organization. Regional Office for Europe
…ddressing the weaknesses in national health systems and the social determinants of TB in every country. Early detection of TB, particularly drug-resistant TB, and adequate treatment with patient-friendly services need to be ensured across the Region. In response to the alarming p…
Letícia Baltar Sobreira, Paula de Souza Silva Freitas, Luciana de Cássia Nunes Nascimento, Anne Caroline Barbosa Cerqueira Vieira, Carolina Maia Martins Sales, et al.
…safe drug dosages with a low side effect, and mainly in the social health determinants and disease process involving MDR-TB.
Elena Kildusheva, Igor Medvinsiy, Sergey Skornyakov, Tayiana Lugovkina, Tatiana Umpeleva, et al.
…R TB cases. <b>Aims and objectives:</b> To determine medico-social features - risk factors of drug resistance development to Mfx and new anti–TB drugs. <b>Methods:</b> Methods of nonparametric statistics were used to analyze the DST results and medico-social features of 84 patien…
Jacqui Wise
…R TB cases. <b>Aims and objectives:</b> To determine medico-social features - risk factors of drug resistance development to Mfx and new anti–TB drugs. <b>Methods:</b> Methods of nonparametric statistics were used to analyze the DST results and medico-social features of 84 patien…
Ariel Torres, Gisselle Trujillo, José Daniel Sánchez
…. This study offers a critical reflection on the magnitude, determinants, and implications of DR-TB in regional penitentiary contexts. A reflective analytical review was conducted in PubMed, Scopus, Web of Science, SciELO, and LILACS, complemented by WHO and PAHO reports, priorit…
Ariel Torres, Gisselle Trujillo, José Daniel Sánchez
…. This study offers a critical reflection on the magnitude, determinants, and implications of DR-TB in regional penitentiary contexts. A reflective analytical review was conducted in PubMed, Scopus, Web of Science, SciELO, and LILACS, complemented by WHO and PAHO reports, priorit…
Monde N, Munyeme M, Chongwe G, Wensman JJ, Zulu M, et al.
…e phenotypic drug susceptibility. Data on the participants' social-demographic characteristics were obtained using a pre-test checklist. Results Overall, the prevalence of resistance to one or more anti-TB drugs was 23.5% (31/132, 95% CI: 16.5-31.6%). A total of 9.8% (13/132, 95%…
Soedarsono S, Mertaniasih NM, Kusmiati T, Permatasari A, Juliasih NN, et al.
…wards treatment (OR = 1.2; 95% CI = 1.1-1.3), limitation of social support (OR = 1.1; 95% CI = 1.0-1.2), dissatisfaction with health service (OR = 2.1; 95% CI = 1.5-3.0)), and limitation of economic status (OR = 1.1; 95% CI = 1.0-1.2)). Conclusions Male patients, jobless, non-reg…
Mareli Claassens, PhD
…pidemic, in terms of clinical, epidemiological, geospatial, social network and laboratory data, to identify transmission hotspots in three regions of Namibia, (ii) evaluate the feasibility of targeted case finding intervention strategies to improve DR-TB control in highly affecte…
Lankamo Ena Digesa, Aklil Hailu Beyene, Erdaw Tachbele Betre
…ent is difficult because it exposes to further economic and social costs that the patients face while seeking help and treatment. Ethiopia is one of the 30 MDR-TB burden countries. There is little research evidence of MDR-TB from the peripheral parts of the country.<bold>Objectiv…
Awanti Sambarey, Kirk Smith, Carolina H. Chung, Harkirat Singh Arora, Zhenhua Yang, et al.
… multiple host and pathogen modalities representing patient social demographics, disease presentations as seen in cChest X rays and CT scans, and genomic records with drug susceptibility features of the pathogen strain from each patient. Our machine learning model, built with div…
Supriya Mallick, Manish Shankar, Satyadeo Choubey, Arshad Ejazi, Rakesh Kumar, et al.
…is continues to be a major threat to mankind and is a major social and economic burden to society. Line probe assay (LPA) is a method for detecting Mycobacterium tuberculosis (MTb) in combination with resistance to rifampicin and isoniazid by first-line LPA, resistance to fluoroq…
Anjali Yadav, Suman Singh, Rakesh Sharma, Santosh Kumar, Ajay Vir Singh, et al.
…-TB drugs (SLDs). The demographic, behavioral, clinical and social information was compared with the results of drug susceptibility testing and analyzed statistically. Out of 279 MDR-isolates, 195 (69.89%) isolates were found resistant to at least one of the SLDs. The rates of ge…
David S.C. Hui, Chi Chiu Leung
…d Kingdom before the availability of effective treatment.25 Social inequities continue to hamper TB control in many parts of the world, and major gaps remain in reaching, diagnosing and effectively treating TB patients, especially in resource-limited settings.26 On 26 September 2…
Karolina Kėvelaitienė, Roma Puronaitė, Valerija Edita Davidavičienė, Birutė Nakčerienė, Edvardas Danila
…TB; however, data on long-term treatment outcomes and their determinants over extended periods are limited. This study evaluated long-term treatment outcomes among adults with pulmonary DR-TB in Lithuania over a 22-year period and assessed associations between treatment outcomes,…
Sharma S, Sarin R, Sahu G, Shukla G
Background Pediatric tuberculosis (TB) constitutes 8% of the total caseload of TB. Children are particularly vulnerable to dissemination of disease and mortality. Aim To determine mortality rate, elucidate type of TB, causes and predictors of mortality, if any, in admitted pediat…