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Km Roma, Suvesh Shrestha, Nirajan Bhandari, Gaurav Jung Shah, Shivam Khetan
Introduction: Pediatric tuberculosis is an infectious disease and is a leading cause of death in Nepal. The incidence of pediatric TB is a key tool of ongoing transmission of tuberculosis within the community and vital indicator of disease control. Its diagnosis is very much chal…
Saïd O. Ali, Hanitriniaina S. C. Samena, Kanto A. Razafindraibe, Annick Robinson
Background: Diagnosing tuberculosis in children remains a challenge especially in low-income countries. The aim of this study was to assess the performance of the scoring system combined to chest x-ray images compared to GeneXpert for diagnosis of pediatric tuberculosis.Methods: …
Lyu C, Shi H, Cui Y, Li M, Yan Z, et al.
Pediatric tuberculosis (TB) is an important part of global TB prevention and control. Diagnosis of childhood TB still remains challenging when using conventional tests, due to the non-specific clinical manifestations and paucibacillary nature of the specimens. Thus, a sensitive, …
Kumar NP, Hissar S, Thiruvengadam K, Banurekha VV, Balaji S, et al.
Background Diagnosing tuberculosis (TB) in children is challenging due to paucibacillary disease, and lack of ability for microbiologic confirmation. Hence, we measured the plasma chemokines as biomarkers for diagnosis of pediatric tuberculosis. Methods We conducted a prospective…
Olbrich L, Nliwasa M, Sabi I, Ntinginya NE, Khosa C, et al.
Introduction An estimated 1.2 million children develop tuberculosis (TB) every year with 240,000 dying because of missed diagnosis. Existing tools suffer from lack of accuracy and are often unavailable. Here, we describe the scientific and clinical methodology applied in RaPaed-T…
Xingyu Lu, Yiyi Hu, Yue Hu, Fei Zhao, Peiyang Fan, et al.
Tuberculosis (TB) is a serious disease that poses a significant threat to the health of children and adolescents, with(PTB) being the most common type. Due to the lack of specificity in clinical manifestations and symptoms, early screening and diagnosis of pediatric pulmonary tub…
Susanna Esposito, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
Tuberculosis (TB) remains a leading cause of morbidity and mortality worldwide, with children representing a particularly vulnerable population in whom diagnosis is often challenging. Pediatric TB is typically paucibacillary and presents with non-specific clinical manifestations,…
Bhatia R, Chauhan A, Kaur K, Rana M, Singh M
In India, children do not get diagnosed with tuberculosis (TB) for reasons such as lack of screening modality at the health-care settings, inadequate sputum sample, and low detection rate. This study aims to assess various modalities for diagnosis of pediatric TB and their cost-e…
Garba MA, Ogunbosi BO, Musa A, Ibraheem RM, Alao MA, et al.
Background The burden of tuberculosis (TB) in Nigeria remains high, and diagnosis in children, a challenge. We aimed to document yield from Xpert Mycobacterium tuberculosis/rifampicin (MTB/RIF) as a mode of diagnosis for children and the variables associated with a positive resul…
Kumar NP, Hissar S, Thiruvengadam K, Banurekha VV, Suresh N, et al.
Pediatric TB poses challenge in diagnosis due to the paucibacillary nature of the disease. We conducted a prospective diagnostic study to identify immune biomarkers of pediatric TB and controls (discovery cohort) and obtained a separate "validation" cohort of confirmed cases of p…
Johari M, Sharma R, Bagri DR, Malhotra B
Background Tuberculosis is an important cause of morbidity and mortality among children. Early diagnosis and treatment in children are challenging, more so in resource-limited, tuberculosis-endemic countries. In 2017, the WHO endorsed the use of CBNAAT for tuberculosis diagnosis.…
Yang Yang, Dan Ye, Zhentao Fei, Ping Liu, Huarui Liu, et al.
**BACKGROUND:** Pediatric tuberculosis (TB) remains a major global health challenge, characterized by age-specific difficulties especially in diagnosis compared to adults. This review summarizes key advances in pediatric TB diagnostics over the past five years. **METHODS:** Lite…
Ira Shah, Zahabiya Nalwalla
Pediatric tuberculosis is a proxy indicator for the tuberculosis (TB) burden in the community. Although there has been a decline in the incidence, it is inadequate to meet the global goals for complete eradication of the disease. Childhood TB remains a challenge for clinicians an…
Tornheim JA, Paradkar M, Zhao H, Kulkarni V, Pradhan N, et al.
Objectives Pediatric tuberculosis (TB) remains difficult to diagnose. The plasma kynurenine to tryptophan ratio (K/T ratio) is a potential biomarker for TB diagnosis and treatment response but has not been assessed in children. Methods We performed a targeted diagnostic accuracy …
Yadav R, Vaidya P, Mathew JL, Verma S, Khaneja R, et al.
Tuberculosis (TB) diagnosis in children still remains a challenge in developing countries. We analyze the performance of Xpert MTB/RIF assay for the diagnosis of pediatric TB under programmatic conditions. We retrospectively analyzed the performance of Xpert MTB/RIF assay from Fe…
Gómez-Valverde JJ, Sánchez-Jacob R, Ribó JL, Schaaf HS, García Delgado L, et al.
Background Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnostic tests, underscore…
S Firoz, Sonia Bhatt
…tudy was to evaluate the efficacy of PCR targeting IS1081in diagnosis of pediatric tuberculosis and compare the results with MGIT culture.Methods: This prospective study was conducted in the department of pediatrics, S.N. medical college, Agra. 100 subjects (28 pulmonary 72 extra…
Bineeta Kashyap, Neha Gupta, Pooja Dewan, NP Singh, Ashwani Khanna
Background: Microbiological confirmation of tuberculosis disease in children remains difficult due to paucibacillary disease and inability to obtain optimal samples. Recently introduced Cartridge based nucleic acid amplification test (CBNAAT) has improved microbiological diagnosi…
Meenu Singh, Ragini Bhatia, Madhuri Devaraju, MalkeetSingh Ghuman, Malaisamy Muniyandi, et al.
Background: According to a study on global burden of tuberculosis (TB), India witnessed 60,000 pediatric deaths in the year 2015. In India, most of the children do not get diagnosed with tuberculosis for various reasons. Aims and Objectives: This study will evaluate the cost-effe…
Matúš Dohál, Věra Dvořáková, Michaela Hromádková, Peter Kunč, Jaroslav Fábry, et al.
**BACKGROUND:** Paediatric tuberculosis (TB) diagnosis remains a challenge due to the paucibacillary nature of the disease, resulting in 51.00% of TB cases remaining undiagnosed, rising to 58% in children under five years of age. **METHODS:** This study evaluates the effectivene…
Juan J. Gómez-Valverde, Ramon Sanchez, José Luis Ribó, H. Simon Schaaf, Lara García Delgado, et al.
<sec> <title>BACKGROUND</title> Tuberculosis (TB) remains a major cause of morbidity and death worldwide, with a significant impact on children, especially those under the age of 5 years. The complex diagnosis of pediatric TB, compounded by limited access to more accurate diagnos…
Roberta Feijó Carvalho, Sandra Valéria Coelho da Silva, Michely Alexandrino de Souza Pinheiro, Rafaela Baroni Aurilio, Edwin Tao Ming Klinkenberg, et al.
Pediatric tuberculosis (TB) remains a diagnostic challenge in Brazil and worldwide. The Brazilian Ministry of Health recommends a clinical scoring system (S-MoH) for children and adolescents with suspected TB. Interpretation of radiographs within this scoring system may require s…
Tuberculosis (TB) is an airborne disease that can be spread from person to person.Children that are below 15 years old (also known as Pediatric Tuberculosis) have high probability to develop life threatening disease and the most substantial number of TB cases are observed in chil…
Erem G, Otike C, Okuja M, Ameda F, Nalyweyiso DI, et al.
… the utility of chest ultrasound scans (CUS) for triage and diagnosis of pediatric tuberculosis (TB) are lacking. Therefore, we aimed to compare CUS features to chest radiography (CXR), which is the recommended imaging modality in children with presumptive pulmonary tuberculosis …
Njeru Kenneth Njue, Mburu Samuel, David Nderu
Delayed detection and case diagnosis of pediatric tuberculosis (TB) is a significant factor in TB transmission, morbidity, and mortality especially in resource-limited settings, such as the sub-Saharan Africa, including Kenya.