Showing 1–25 of 157 documents
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Christoph Lange, Dumitru Chesov, Olha Konstantynovska, Anna-Maria Mandalakas, Zarir Udwadia
Until the coronavirus disease 2019 pandemic, tuberculosis had been the leading cause of death by an infectious disease worldwide. According to the WHO, there were 1.41 million deaths attributed to tuberculosis in 2019. Globally, the burden of tuberculosis is asymmetrically distri…
Shruti Kaushal, Sunil Kumar Dhatwalia, Rakesh Yadav, Sumedha Sharma, Pankaj C Vaidya, et al.
…ra), as first-line diagnostic tests for detecting pulmonary tuberculosis (PTB) and rifampicin resistance in children suspected of having the disease. Respiratory specimens (gastric lavage/bronchoalveolar lavage/sputum/endotracheal aspirate) obtained from 116 children with presump…
Torane VP, Nataraj G, Kanade S, Deshmukh CT
…objective Global TB report 2021 mentions 11 % prevalence of pediatric TB, whereas 5.65% of the cases were reported from India in 2020. India features in the list of TB high burden countries, HIV-TB high burden and MDR-TB high burden countries. The diagnosis of pulmonary tuberculo…
Srabani Banerjee, Melissa Severn
Tuberculosis (TB) is one of the top 10 causes of death, worldwide. Worldwide 10 million people developed TB in 2017, (i.e.,133 cases per 100,000).– However, only 6.4 million cases were reported to WHO, indicating that 36% of cases were undiagnosed or not reported. According to a …
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
Background: Approximately 81% of all childhood tuberculosis cases occur among 22 high-burden countries and Ethiopia ranks eighth among these high burden countries. The GeneXpert Mycobacterium tuberculosis DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberc…
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ountries (LMICs) with a high burden of infectious diseases. Tuberculosis (TB), a major source of morbidity and mortality worldwide, was further exacerbated by the COVID-19 pandemic, resulting in up to 1.5 million deaths in 2020 [[1]WHOGlobal tuberculosis report 2021. World Health…
Geweniger A, Janda A, Eder K, Fressle R, Kannan CV, et al.
Background The microbiological diagnosis of pulmonary tuberculosis (Tb) in a pediatric population is hampered by both low pathogen burden and noncompliance with sputum sampling. Although endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has been found u…
Ana Alvarez, Mobeen H. Rathore
…ies have led to several new recommendations in the areas of diagnosis and treatment of pediatric tuberculosis in the past few years. Due to the low incidence of tuberculosis in the United States, many primary care providers may not be familiar with these new recommendations.After…
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Hebert Dedehouanou, Yazid Taïrou Toure, Laurence Yehouenou
The diagnosis of bacteriologically confirmed pulmonary tuberculosis in Benin and in other developing countries relies on the search for acid-fast bacilli through microscopy despite its limited sensitivity. The objective of this study is to evaluate the contribution of the Xpert t…
Abstract BACKGROUND Tuberculosis (TB) is a rare but potentially devastating infection among Canadian children. Accurate diagnosis and initiation of treatment are limited in part by the fact that it takes 2–6 weeks for culture results to be confirmed. Xpert MTB/RIF (Xpert) is a ra…
Katherine Laycock, Karl-Günter Technau, Patricia Lelo, Watsamon Jantarabenjakul, Caroline Yonaba, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of morbidity and mortality for children living with HIV (CLHIV), with gaps in TB screening, diagnostics, management, and TB preventive therapy (TPT). We investigated reported practices in these domains at sites caring for …
Imperiale BR, Nieves C, Mancino B, Sanjurjo M, Tártara S, et al.
…re is a critical need to improve the diagnostic accuracy of tuberculosis (TB) in children. Several techniques have been developed to improve the quality of sputum samples; however, these procedures are very unpleasant and invasive and require hospitalization and trained personnel…
K S S, Saldanha PRM, Kushwah S, Prabhu AS
Introduction In spite of having BCG vaccination and tuberculosis control program for the last 50 years, prevalence of tuberculosis continues to be high in India. Inadequate diagnostic methods, suboptimal treatment and monitoring, and the lack of vigilant reporting system are some…
I. B. Kulikova, I. А. Vаsilyevа, А. И. Казаков, Н. И. Клевно, С. А. Стерликов, et al.
The objective: to evaluate tuberculosis situation in the Russian Federation among children aged 0-17 years based on the analysis of key epidemiological rates from official statistics for 2023. Subjects and Methods. Information from official statistical surveillance forms was stud…
Christoph Lange, Professor
…l diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investigators will use target next generation sequencing t…
Ambreen Ahmad, Islam Gul, Muhammad Idrees, Ansaar Hussain
…ine the performance of Genexpert in detecting Mycobacterium Tuberculosis in children comparedwith microscopy and MGIT culture and determining the sensitivity pattern of Mycobacterium Tuberculosis in childrenat Hayatabad Medical Complex, Peshawar.Study Design: This is cross-sectio…
Chiang SS, Sheremeta Y, Padilla RS, Jenkins HE, Horsburgh CR Jr, et al.
Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite the fact that these countries have the highest proportion of TB cases that are MDR. We aimed to examine pediatric MDR-TB in Ukraine. This retrospective cohort st…
Hoffman CJ, France T, Cram T, Bodmer JL, Sanders JS
…minated disease in this case. We review the difficulties in diagnosis and treatment of pediatric MDR-TB.
Philippe Ngwala Lukanu, Papy Lusameso, Angel Matota Shoma, Jeanne Tshibungu, Isabelle Kufundu, et al.
Background: A late diagnosis of tuberculosis has serious consequences for the spread and outcome of the disease. Delayed diagnosis is an important indicator of the quality of a tuberculosis control program. The aim of this study is to identify the determinants of delay in tubercu…
Jouego CG, Agbor VN, Noeske J, Manuel NA, Ayuk LN
Background Tuberculosis remains a major cause of morbidity and mortality worldwide, especially in developing countries. The diagnosis and treatment of multi-drug resistant tuberculosis (MDR-TB) in children remain a major limitation in this setting, largely due to difficulties in …
Gaensbauer JT, Dash N, Verma S, Hall DJ, Adler-Shohet FC, et al.
Pediatric multidrug-resistant tuberculosis (MDR-TB) remains a significant global problem, and there are numerous barriers preventing children with MDR-TB from being identified, confirmed with microbiologic tests, and treated with a safe, practical, and effective regimen. However,…
Melchor VG Frias, IV, MD, Anjanette Reyes-De Leon, MD, Louvina van der Laan, MD
…id plus an optimized background regimen (OBR) of other anti-tuberculosis drugs in pediatric participants who completed Study 242-12-232 (NCT01856634). This study will assess the safety, tolerability, pharmacokinetics, and efficacy of delamanid plus an optimized background regime…
Misra S, Misra N, Seepamore B, Holloway K, Singh N, et al.
…he experiences of children being treated for drug-resistant tuberculosis (DR-TB), and most work in the area has been done with older children and adolescents. Comprehensive explorations of the caregiver experiences in this area are also lacking. Objective To describe the experien…
Mohamad Zacky Amirullah, Sudarto Sudarto, Zen Ahmad, Bryan Arista Hartono
Rifampicin-resistant tuberculosis remains a major global health challenge, particularly when occurring as primary resistance in patients without prior tuberculosis treatment. Tuberculosis drug resistance incidence in Indonesia expected 2.2% primary and 25% with prior anti-tubercu…