Showing 1–18 of 18 documents
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Dutta NK, Tornheim JA, Fukutani KF, Paradkar M, Tiburcio RT, et al.
Pediatric tuberculosis (TB) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 1…
Siamisang K, Rankgoane-Pono G, Madisa TM, Mudiayi TK, Tlhakanelo JT, et al.
…duction Globally, the amount of research on the outcomes of pediatric tuberculosis (TB) is disproportionately less than that of adult TB. The diagnosis of paediatric TB is also problematic in developing countries. The aim of this study was to describe the outcomes of pediatric TB…
Cielo Ríos, Marcela Vásquez Rojas, Martha Lucía Serrano, Alexandra Porras, Ricardo Luque, et al.
We investigated the delays in the diagnosis of tuberculosis and/or HIV, their treatment initiation, and factors associated with each delay. All drug-susceptible tuberculosis cases diagnosed in 2014 and 2015 in Colombia, with a confirmed diagnosis of HIV were included. A total of …
Apolisi I, Cox H, Tyeku N, Daniels J, Mathee S, et al.
…th household exposure to multidrug- or rifampicin-resistant tuberculosis (MDR/RR-TB) are at high risk of developing TB disease. Tuberculosis preventive therapy (TPT) is recommended, but programmatic experience is limited, particularly for adolescents. Methods We conducted a prosp…
Finlayson H, Lishman J, Palmer M
…urrent review identifies recent advances in the prevention, diagnosis, and treatment of childhood tuberculosis (TB) with a focus on the WHO's updated TB management guidelines released in 2022. Recent findings The COVID-19 pandemic negatively affected global TB control due to the …
Heiman F Wertheim, PhD
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis. Diagnostic criteria are non-specific and culture confirmation is challenging, as sputum samples are not…
Fry S, Barnabas S, Cotton MF
Purpose of review Although tuberculosis (TB) causes much morbidity and mortality in children, diagnosis and treatment remain challenging. Recently, children have gained increasing attention in research and clinical trials driving improved contact management, case identification a…
Prince Malonda ma Ndungi, Blaise Idiamwana Kutokama, Bijou Masokolo Malamba, Dosithée Ngo-Bebe
Background Tuberculosis, the second deadliest infectious disease in the world after COVID-19, is caused by Mycobacterium tuberculosis. This bacterium most commonly affects the lungs. Economic and financial barriers can hinder access to healthcare services for the diagnosis and ma…
M.G. Mustapha, Garba Mohammed Ashir, AI Rabasa, Asmaa Farouk, Hassan Abdullahi Elechi, et al.
Tuberculosis (TB) is an important infectious disease of public health concern. The effects of TB on children in terms of morbidity and mortality is more than that of adults. These may not be unconnected with the differences in characteristics and peculiarities of the disease in c…
Silvia S. Chiang, Helen E. Jenkins
Tuberculosis (TB) kills ∼1.5 million people worldwide each year.1 Among children and adolescents infected with TB, those <5 years old and those with HIV coinfection have a higher risk of death.2–4 Not only have few researchers quantified the impact of antiretroviral therapy (ART)…
Yasobant S, Shah H, Bhavsar P, Patel J, Saha S, et al.
Tuberculosis (TB) is the second leading cause of death due to infectious diseases globally, and delay in the TB care cascade is reported as one of the major challenges in achieving the goals of the TB control programs. The main aim of this study was to investigate the delay and r…
Nicole Robertson, J. Zachary Porterfield, Alex Kayongo, Bruce Kirenga, Robert Kalyesubula, et al.
Abstract Background Pulmonary tuberculosis (TB) is the leading infectious cause of death globally with an estimated 1.7 billion people currently infected with Mycobacterium tuberculosis and at risk of developing TB. While the treatment of drug-susceptible pulmonary TB is highly e…
Anbesan Hoole, Ahsan Ilyas, Sunaina Munawar, Matthew Cant, Rizwan Hameed, et al.
…l lung disease. Key Messages What is known about this topic Tuberculosis (TB) is the most common cause of bronchiectasis in South Asia, but little is known about microbiology or clinical characteristics of post-TB Bronchiectasis. What this study adds Post TB Bronchiectasis has a …
Malika Gabdullina, Saya Gazezova, Gulzhan Ayapova, Manar Smagul, Roberta Horth, et al.
… TB related services around the world, including detection, diagnosis and treatment. The purpose of this research is to assess the impact of the COVID-19 pandemic on TB treatment outcomes in Almaty, and to determine risk factors associated with said outcomes by examining data fro…
M.J. Cavaco, Sofia Giusti Alves, L. Mateus, André Nunes, Ricardo Cordeiro, et al.
<b>Introduction:</b> Tuberculosis (TB) remains a major health problem, with extensive research on case detection and treatment outcome. However, little is known about what happens after treatment completion. In the First International Symposium on post-TB lung health (2020), the …
Nelly Solomonia, K Vacharadze
…ever identification of susceptibility to the different anti-Tuberculosis (TB) drugs in different time period, not in all cases gives us opportunity to simultaneously know susceptibility to the all anti-TB drugs and to build an appropriate treatment regimens based on complete indi…
M R Marll, M Magee, N Glover, T Ngwanto, N Mofokeng, et al.
Abstract Rationale Approximately half of all tuberculosis (TB) survivors develop post-TB lung disease (PTLD), defined as persistent respiratory abnormalities despite a microbiological cure. Fibrosis, which typically presents as a restrictive ventilatory impairment on pulmonary fu…
John Metcalfe, MD, PhD, MPH
…th standard of care (SOC) regimen for drug-susceptible (DS) tuberculosis (TB). This study compared a 3-month rifapentine (RPT)/clofazimine (CFZ)-containing regimen with a CFZ loading dose with the 6-month standard of care (SOC) for drug-susceptible (DS) tuberculosis (TB). Rando…