Showing 1–25 of 200 documents
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Kelly Walblay, Tristan D. McPherson, Elissa Roop, David F. Soglin, Ann Valley, et al.
…evalence of C. auris colonization has not been described in pediatric populations in the United States, and limited data exist on CPO colonization in children outside intensive care units. The Chicago Department of Public Health (CDPH) conducted a PPS to assess C. auris and CPO c…
Raj Narayan Yadav, Manpreet Bhalla, Yellanki Yashwanth Chowdary, Ajoy Kumar Verma, Gaurav Kaushik, et al.
**BACKGROUND:** Pediatric tuberculosis is an important subset of tuberculosis infection burden with a high detection gap due to paucibacillary nature. GeneXpert MTB/RIF assay detects rifampicin resistant (RR) Mycobacterium tuberculosis (MTB) that provides bacillary load and mutat…
Madzgharashvili T, Salindri AD, Magee MJ, Tukvadze N, Avaliani Z, et al.
Background Among pediatric patients with multidrug-resistant tuberculosis (MDR-TB), limited data exist regarding treatment outcomes in the context of the new and repurposed second-line TB drugs (SLDs). We aimed to describe the treatment outcomes among pediatric MDR-TB patients re…
Epperson K, Crane C, Ingulli E
Donor derived infections (DDIs) in pediatric kidney transplant recipients remain challenging to diagnose and can result in serious morbidity and mortality. This review summarizes the current guidelines and recommendations for prevention, diagnosis, and treatment of unexpected DDI…
Mandira Chakraborty, Sayani Sardar, Rituparna De, Malabika Biswas, Maria Teresa Mascellino, et al.
…tance patterns of pathogens causing infections in adult and pediatric patients in the ICUs of a tertiary care hospital in Kolkata, India. A cross-sectional, retrospective study was conducted from January 2022 to October 2022 on a total of 139 adult and 146 pediatric patients. Dep…
Daniel Mashiach, Justin Shon, Raquel Mashiach, Gregory Ayzenberg, Osnat Barazani, et al.
Pediatric tuberculosis (TB) remains a critically underrecognized contributor to global childhood morbidity and mortality, with the highest burden concentrated in low-resource settings. Although children comprise a minority of overall TB cases, mortality is disproportionately high…
Harichander S, Wiafe E, Mensah KB, Bangalee V, Oosthuizen F
…te the incidence of TB and drug-resistant (DR) TB among the pediatric population. It also reviews the therapeutic options available to treat the condition. Methods A comprehensive search for all relevant evidence was conducted. The following databases were searched: MEDLINE, CINA…
Sun WW, Yang M, Chen XH, Fan LC, Wu HY, et al.
…ety of an all-oral bedaquiline (BDQ)-containing regimen for pediatric multidrug/rifampicin-resistant tuberculosis (MDR/RR-TB) through a multicenter, retrospective study in China. Methods In the study, pediatric patients receiving all-oral BDQ-containing regimen (BDQ group) with c…
Chiang SS, Sheremeta Y, Padilla RS, Jenkins HE, Horsburgh CR Jr, et al.
Few reports have described pediatric Multidrug-resistant Tuberculosis (MDR-TB) in the former Soviet republics, despite the fact that these countries have the highest proportion of TB cases that are MDR. We aimed to examine pediatric MDR-TB in Ukraine. This retrospective cohort st…
Jeffrey Hafkin, MD
The purpose of this trial is to determine the pediatric dose of delamanid that is equivalent to the adult dose already shown to be effective against multidrug-resistant tuberculosis. This trial will investigate the pharmacokinetics (PK) and safety of delamanid administered for 1…
Ahmed R. Rezk, Somaia Abdelhammed Bawady, Nashwa Naguib Omar
…orldwide threat in intensive care units particularly in the pediatric intensive care units with a major cause of morbidity and mortality among this age group. The aim of the study is to determine the prevalence and risk factors predisposing to multidrug-resistant organisms (MDROs…
Ouissal Aissaoui, Lina F. Berrada, O. Ettouki, Samira Kalouch, K. Yaqini, et al.
…tion of patients with Raoultella terrigena infection in the pediatric intensive care unit, and therefor highlight the challenges physicians face while managing these multi drug resistant emergent pathogen. Methods: We conducted a retrospective study, over a period of 4 months (01…
Dayal R, Agarwal D, Bhatia R, Bipin C, Yadav NK, et al.
… of latent tuberculosis (TB) infection and TB disease among pediatric household contacts of adult drug resistant (MDR) and drug susceptible (DS) TB patients and to identify the risk factors for occurrence of TB infection in the contacts. Methods Pediatric household contacts (less…
Mustafa G, Almarshad F
… countries. This study focuses on the burden and pattern of pediatric and adolescent MDR-TB in a tertiary care hospital setting. Aims/objectives The main objective is to evaluate MDR-TB's prevalence and resistance patterns among pediatric and adolescent patients, highlighting cri…
Jouego CG, Agbor VN, Noeske J, Manuel NA, Ayuk LN
…o difficulties in isolating Mycobacterium tuberculosis from pediatric specimens, management with toxic second line drugs, and practically the inexistence of contact tracing. In 2016, the World Health Organization (WHO) recommended a standardized 9-month regimen for adults and chi…
Kashyap B, Jhanjharia S, Saha R, Gomber S
Background Multi-drug resistance (MDR) in pediatric tuberculosis (TB) is a growing global threat. Unavailability of conventional or molecular drug susceptibility test (DST) in resource-limited settings often impede the determination of the extent of first line anti-tubercular dru…
Vivek Viswanathan
… The intersection of sociodemographic factors with DR-TB in pediatric populations remains understudied, especially in rapidly urbanizing environments. Objective: To investigate the relationship between sociodemographic factors and DR-TB in pediatric patients at a tertiary care ce…
Maika Kamille Mortel, Ana Patricia Alcasabas, Anna Lisa Ong‐Lim
… This report describes the clinical profile and outcomes of pediatric patients with acute lymphoblastic leukemia (ALL) diagnosed with tuberculosis. Methods Medical records of pediatric patients with ALL consulting at the University of the Philippines – Philippines General Hospita…
Melchor VG Frias, IV, MD, Anjanette Reyes-De Leon, MD, Louvina van der Laan, MD
…ackground regimen (OBR) of other anti-tuberculosis drugs in pediatric participants who completed Study 242-12-232 (NCT01856634). This study will assess the safety, tolerability, pharmacokinetics, and efficacy of delamanid plus an optimized background regimen in pediatric partici…
Mane SS, Shrotriya P
…TB in children, which accounts for around 31% of the global pediatric TB load. However, over the past 10 y, children have consistently made up 6-7% of all patients treated yearly under the National Tuberculosis Elimination Programme (NTEP). There is an estimated detection gap of …
Sekarsari D, Handoyono QF, Amal MY, Maharani MAP, Hendriarto A
… of radiological imaging in the diagnosis and management of pediatric tuberculous spondylitis in impoverished nations. The patient's complex medical history highlights the socioeconomic factors contributing to tuberculosis burden. Early and comprehensive radiological assessment, …
Misra S, Misra N, Seepamore B, Holloway K, Singh N, et al.
…mpacts their physical, mental, and social well-being. These pediatric patients and their families therefore develop strategies for coping with these disruptions to their lives. In general, there were major disruptive experiences that resulted from the process around receiving a d…
Jungrungrueng T, Anugulruengkitt S, Lauhasurayotin S, Chiengthong K, Poparn H, et al.
…terial infection, and clinical impact of these organisms on pediatric oncology patients with febrile neutropenia. Methods A retrospective descriptive study of oncologic patients aged less than 15 years who were diagnosed with febrile neutropenia in King Chulalongkorn Memorial Hos…
W. Richter, Keira A. Cohen
Pediatric otomastoiditis due to Mycobacterium abscessus can be a devastating infection that presents multiple treatment challenges. Van Wijk et al. report the use of a structured approach with a standardized regimen of intravenous (i.v.), topical, and oral antibiotics and surgica…
Warnken Z, Trementozzi A, Martins PP, Parekh J, Koleng JJ, et al.
…vidable oral dosage form has limited the use of the drug in pediatric populations, who may require lowering of the dose to reduce the likelihood of adverse drug events. In this study, pediatric-friendly CFZ mini-tablets were prepared from micronized powder via direct compression.…