Showing 1–18 of 18 documents
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Jun Ma, Lin Fan, Hongcheng Liu, Wenting Li, Wenwen Sun
…onclusion: RR/MDR-EPTB is different from RR-MDR/PTB in both epidemiology and clinical. Clinicians should recommend Xpert in early stage and use fluoroquinolones cautiously in cases suspected TB.
Irina Kostyukova, Anna Vyazovaya, О. А. Пасечник, Igor Mokrousov
Background . The prevalence of multidrug-resistant tuberculosis poses a serious public health problem, hampering the success of tuberculosis control programs around the world. Aim : Evaluation of epidemiological manifestations of tuberculosis and molecular genetic characteristics…
Kostyukova I, Pasechnik O, Mokrousov I
Russia is a high-burden area for multidrug-resistant tuberculosis (MDR-TB). Here, we studied the epidemiological situation and drug resistance patterns of Mycobacterium tuberculosis in the Omsk region in Western Siberia. M. tuberculosis isolates ( n = 851) were recovered from new…
Divya Bhatt, Rashmi Ratnam, Faisal Abbas, Manu Singh, Urmila Singh, et al.
**BACKGROUND:** Ageing affects the clinical presentation of diseases due to associated comorbidities, often leading to diagnostic imprecision and specialized treatment needs in healthcare systems that are not well-equipped to address such challenges. Robust data analysis of geria…
Ismail NA, Omar SV, Moultrie H, Bhyat Z, Conradie F, et al.
… a cross-sectional and longitudinal analysis evaluating the epidemiology, genetic basis, and treatment outcomes associated with bedaquiline resistance, using data from South Africa (2015-19). Methods Patients with drug-resistant tuberculosis starting bedaquiline-based treatment h…
Dana Auganova, Sabina Atavliyeva, Nour Gharbi, Elena Zholdybayeva, Yuri Skiba, et al.
Kazakhstan has one of the highest incidence rates of MDR-TB in the WHO European Region. However, data on the genomic diversity of circulating Mycobacterium tuberculosis strains in Kazakhstan remains limited. We performed whole-genome sequencing on 177 clinical M. tuberculosis iso…
Dagne B, Desta K, Fekade R, Amare M, Tadesse M, et al.
Background Drug-resistance in Mycobacterium tuberculosis complex remains a major health burden in human history and still is a major leading cause of death in developing countries including Ethiopia. Early detection of all forms of drug-resistant Tuberculosis(TB) is a key factor …
О. А. Пасечник, Anna Vyazovaya, A. I. Bloch, Irina Yarusova, M. P. Tatarintseva, et al.
Relevance. The spread of the epidemic and resistant Mycobacterium tuberculosis genotypes presents a serious threat to the implementation of the national tuberculosis control program in Russia. The study aimed to assess the trends in the development of the epidemic process of tube…
Greif G, Coithino C, Bentancor MN, Robello C
Whole genome sequencing (WGS) is sensitive tool for the analysis of tuberculosis transmission and drug-resistance. We used WGS to analyze the Mycobacterium tuberculosis evolution from isoniazid monoresistance to MDR/preXDR during a prolonged household outbreak. The outbreak start…
Kamal Ahmadi, Nahid Madadi-Goli, M Masoumi, Mahshid Nasehi, Seyed Davar Siadat, et al.
Introduction: Tuberculosis, caused by Mycobacterium tuberculosis, is one of the most common infectious diseases worldwide. Epidemiological studies of M. tuberculosis drug resistance are critical for improving patient treatment approaches and controlling the spread of tuberculosis…
Elisa Tagliani, Emanuele Borroni, Daniela María Cirillo
Aims and objectives: In the present study, we report on the cross-border clusters involving Italian MDR-TB strains collected in the framework of the ECDC supported EUSeqMyTB project. This pilot study was conducted as retrospective/prospectic WGS-based surveillance project to moni…
Tatiana Umpeleva, Kseniya Belousova, Ludmila Golubeva, Nataliya I. Eremeeva, Diana Vakhrusheva
<b>Background:</b> The Beijing B0/W148 is a clone variant of M. tuberculosis (MTB) that is often detected in tuberculosis patients in Russia. It has stronger association with multidrug resistance and possesses unique pathogenic properties. <b>Objectives:</b> To identify the spect…
Bouziane F, Allem R, Sebaihia M, Kumanski S, Mougari F, et al.
Objectives To characterise the genotypes of multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) isolated in Algeria, where there is a low MDR-MTB incidence rate. Methods Ten MDR isolates and one resistant to isoniazid were investigated by PCR-Sanger sequencing for 10 loci …
Conceição EC, Loubser J, Guimarães AEDS, Sharma A, Rutaihwa LK, et al.
…IRU-VNTR) genotyping, whole-genome sequencing (WGS) and geo-epidemiology analysis. Of the 28 SIT2517/T1 isolates, 19 (67.9%) could be genotyped by 24-loci MIRU-VNTR and 15 by WGS. All belonged to sublineage 4.1.1.3, distinct from other representative Lineage 4 isolates identified…
Yu. D. Mikhailova, Marina Makarova, L. Yu. Krylova, S. G. Safonova, В. И. Литвинов
Due to the widespread drug resistance of M. tuberculosis (MTB), it is necessary to assess the possibility of using drugs with antimycobacterial activity previously used in other pathologies, e.g. clofazimine, in anti-tuberculosis chemotherapy regimens. The aim was to determine th…
Olabisi Flora Davies-Bolorunduro, Bharkbhoom Jaemsai, Wuthiwat Ruangchai, Thanakron Noppanamas, Manon Boonbangyang, et al.
There are four major lineages of Mycobacterium tuberculosis (Mtb) whose geographic ranges vary considerably. Mtb lineage 2 (L2) or the East Asia lineage is particularly common in East and Southeast Asia, and also reported worldwide. Most L2 isolates belong to a sublineage L2.2 wh…
С. Н. Жданова, Anna Vyazovaya, I. B. Lebedeva, V. V. Sinkov, И. Г. Кондратов, et al.
Introduction. The Kemerovo region — Kuzbass is characterized by a high prevalence of multidrug-resistant (MDR) tuberculosis (TB), including coinfection with HIV (HIV/TB). A previously unknown in Russia relationship between MDR and the Beijing Central Asian Outbreak (CAO) subtype …
Ghosh A, Biswas VK, Bal HB, Das D, Pati S, et al.
Whole genome sequencing has been used to investigate the genomic diversity of M. tuberculosis in the northern and southern states of India, but information about the eastern part of the country is still limited. Through a sequencing-based strategy, this study seeks to comprehend …