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Qi Y, Li K, Li Y, Guo D, Xu J, et al.
…ularly interspaced short palindromic repeats (CRISPR)-based diagnostics in TB detection. Currently, the clinical diagnosis of M. tuberculosis infection mainly depends on pathogenic and molecular biological methods, including sputum smear, sputum culture, and Xpert. Although CRISP…
Tjale MA, Ombinda-Lemboumba S, Maphanga C, Mthunzi-Kufa P
… diagnosis, and in addition, we explore point of care (POC) diagnostics as an alternative way to develop TB diagnostic tests and further evaluate whether bioinformatics can be used as an additional screening tool for identification of possible TB biomarkers for the development of…
Shyamkumar Sriram, Tareq Abualfaraj, Manal Ali Alsharif, Marwa Zalat, Saad Madani Alawfi, et al.
Patients with latent tuberculosis infection are mainly asymptomatic, but they still carry a notable risk of developing active TB, particularly when the host becomes immunosuppressed. Hence, appropriate diagnosis and management for LTBI are essential. Tuberculin skin test (TST) an…
Mamishi S, Pourakbari B, Sadeghi RH, Marjani M, Mahmoudi S
Introduction Several studies have been conducted to find new biomarkers for the discrimination of Latent Tuberculosis Infection (LTBI) from active TB (ATB); however, their findings are inconsistent. The aim of the current study was to evaluate the potential of in vitro antigenspe…
Tulane University
Pediatric tuberculosis (TB) continues to pose diagnostic challenges in low- and middle-income countries with high rates of TB disease, due to the well-described impact of paucibacillary disease in children, and current TB culture and polymerase-chain reaction tests are of limited…
Sofia Kostoudi, Robert Hammond
…aims to examine and analyze the present and proposed future diagnostics in the identification of latent tuberculosis. Design Systematic Review Methods PubMed and Scopus were scanned as primary databases during May 2022. Exclusion criteria for the papers scanned included patients …
Alice Halliday, Pooja Jain, Long Hoàng, Robert Parker, Mica Tolosa-Wright, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Halliday A, Jain P, Hoang L, Parker R, Tolosa-Wright M, et al.
Background Tuberculosis (TB) is a devastating disease for which new diagnostic tests are desperately needed. Objective To validate promising new technologies [namely whole-blood transcriptomics, proteomics, flow cytometry and quantitative reverse transcription-polymerase chain re…
Eduarda Rabello, Fernanda de-Paris
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, a burden further exacerbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently av…
Brinkmann F, Hofgrefe J, Ahrens F, Weidemann J, Berthold LD, et al.
Background The differentiation between latent tuberculosis infection (LTBI) and tuberculosis (TB) relies on radiological changes. Confirming the diagnosis remains a challenge because typical findings are often missing in children. This study evaluates diagnostic sensitivity, spec…
Xie L, Zhu G, Long S, Wang M, Cheng X, et al.
Background Current diagnostic methods cannot effectively distinguish between latent tuberculosis infection (LTBI) and active tuberculosis (ATB). This study aims to explore novel non-invasive diagnostic biomarkers for LTBI and to elucidate possible molecular mechanisms of LTBI pat…
Nsikak Godwin Etim, Tatfeng Youtchou Mirabeau, Olwayemisi A. Olorode, Miriam U. Nwodo, Sylvester Chibueze Izah
Various diagnostic methods are employed to detect tuberculosis (TB).One of the most commonly used tools is the microscopic examination of sputum samples, utilizing acid-fast staining to identify Mycobacterium tuberculosis.Chest X-rays are instrumental in identifying TB-related lu…
Jee Whang Kim, Hemu Patel, Richard Halliwell, Raman Verma, RC Free, et al.
<h3>Introduction</h3> Use of rapid molecular diagnostics such as Xpert MTB/RIF and Xpert MTB/RIF Ultra (Xpert-Ultra) is endorsed by World Health Organization for rapid diagnosis of TB. Xpert-Ultra has improved sensitivity, but utility in low TB-prevalent settings, where paucibaci…
Linsheng Li, Peilong Wang, Zhiming Li, Guangliang Bai, Zhaoyang Ye, et al.
…s a persistent challenge in global TB control, with current diagnostics failing to reliably distinguish these states or predict progression. This study introduces the HeptaTB Dx Model, the first diagnostic signature derived from the crosstalk between cuproptosis and ferroptosis-t…
Shleider Carnero Canales C, Marquez Cazorla J, Furtado Torres AH, Monteiro Filardi ET, Di Filippo LD, et al.
…propelled research into diagnostic tests based on molecular diagnostics, pulmonary immunity, epigenetics, metabolomics, and a current focus on next-generation MTB antigen-based skin test (TBST). It is within these emerging methods that the potential for accurate distinction betwe…
Yi En Ding, Matthew Tze Jian Wong, Mohd Nor Norazmi, Venugopal Balakrishnan, Gee Jun Tye
…o enhance distinction within the infection timeline in LTBI diagnostics. Advancement in immune profiling, dormancy antigen, along with molecular and transcriptomic approaches holds great promise to develop a diagnostic tools with better accuracy to differentiate recent from remot…
Shi H, Yang L, Zhang F, Zhou Y, Zhou Y
Rapid and accurate methods for the diagnosis of tuberculous pleurisy (TP) are urgently needed. Activation markers of tuberculosis (TB)-reactive T cells are considered promising for the diagnosis of active TB (ATB). Different activation indexes may play different roles in the prog…
Maria Olivia Fotiou, Amelia Holloway, Anoop Kurian Mathew, Alexis Jones, Jessica Manson
Abstract Introduction Severe systemic lupus erythematosus (SLE) can present with multi-organ involvement, including respiratory manifestations. SLE can both mimic and trigger hyperinflammatory states, including haemophagocytic lymphohistiocytosis (HLH). This case describes a pati…
Declan Emegano, Nazife Sultanoğlu, Efe Precious Onakpojeruo, Berna Uzun, Dilber Uzun Ozsahin, et al.
BACKGROUND/AIMS: Latent tuberculosis infection (LTBI) remains a critical challenge in global tuberculosis (TB) control efforts, necessitating effective diagnostic techniques.This study provides a comprehensive analysis of 7 diagnostic methods for LTBI, including QuantiFERON-TB an…
Syed MA Zaidi, Anna K. Coussens, James A. Seddon, Tamara Kredo, Digby F. Warner, et al.
Abstract Background There is growing recognition that tuberculosis (TB) infection and disease exists as a spectrum of states beyond the current binary classification of latent and active TB. Our aim was to systematically map and synthesize published conceptual frameworks for diff…
Chendi Bih Hycenta, Vanessa Mwebaza Muwanga, Tracey Jooste, Martin Kidd, Simon C. Mendelsohn, et al.
<h3>Background</h3> Several host blood transcriptomic signatures have shown promise as tuberculosis (TB) diagnostic candidates, supporting the use of such biomarkers in prototype RNA-based point-of-care tests. Further validation of these signatures across different clinical and e…
Yoshikazu Mutoh, Yusuke Minato, Yuya Kawamoto, Shogo Hanai, Takumi Umemura, et al.
Evidence regarding the diagnostic value of quantitative interferon-gamma release assay (IGRA) results in elderly populations is limited, and large-scale data for QuantiFERON-TB Gold Plus (QFT-Plus) are scarce. We evaluated QFT-Plus and T-SPOT.TB (T-SPOT) for distinguishing active…
R A, D M, Kv L, Suriya VR, R K
Testing for latent tuberculosis infection is essential for diagnosing Mycobacterium tuberculosis infections in asymptomatic individuals. Preventing the transition of latent to active tuberculosis is imperative, especially in high-risk populations such as healthcare workers. Inter…
Jung‐Kyu Lee, Dong-Hyun Joo, Eun Young Heo, Deog Kyeom Kim, Hee Soon Chung
<b>Backgrounds:</b> The first step in diagnosing latent tuberculosis (TB) in patients with confirmed TB infection is to exclude active TB. The currently recommended test for this is chest X-ray (CXR), with limited data on whether computed tomography (CT) can be a better alternati…
Garlant HN, Ellappan K, Hewitt M, Perumal P, Pekeleke S, et al.
Tuberculosis (TB) remains a significant global health crisis and the number one cause of death for an infectious disease. The health consequences in high-burden countries are significant. Barriers to TB control and eradication are in part caused by difficulties in diagnosis. Impr…