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Mayu Hikone, Yuya Kondo, Yu Takaizumi, Wataru Kagaya, Katharina Kranzer, et al.
**INTRODUCTION:** Current diagnostics for tuberculosis (TB) rely on sputum or site-specific specimen collection, posing critical limitations in certain populations. Urine has emerged as an alternative specimen, as demonstrated by urine lipoarabinomannan (LAM) testing. Beyond LAM,…
Margaret C Siu, Maria Selinopoulou, Susan Abarca Salazar, Jonathan P Sturgeon, Julie Huynh, et al.
…DS:** We systematically reviewed host-based gene expression diagnostics for pediatric EPTB. PubMed, Embase and Cochrane Library (January 1965-May 2025) were searched for studies in children (0-18 years) with EPTB. Exclusions were adult-only studies, mixed data on pulmonary TB and…
Hueda-Zavaleta M, Gomez de la Torre JC, Minchón-Vizconde D, Barletta-Carrillo C, Copaja-Corzo C, et al.
Background Molecular tests have contributed to reducing the mortality rate through early and accurate diagnosis of tuberculosis (TB). This is due to their low processing complexity and diagnostic accuracy superior to conventional methods. Objective To evaluate the diagnostic perf…
Emily MacLean, H. Manisha Yapa
… High priority target product profiles for new tuberculosis diagnostics: report of a consensus meeting.https://www.who.int/publications/i/item/WHO-HTM-TB-2014.18Date: 2014Date accessed: February 12, 2024Google Scholar although signatures performed better than W4SS. All signatures…
David SC Hui, MD
Tuberculosis (TB) is an endemic infectious disease in Hong Kong and a global health threat. Tuberculous pleuritis (TBP) is the most common form of extrapulmonary tuberculosis in China. Its presentation is frequently non-specific and the diagnosis is challenging due to its pauciba…
Ka Pang Chan, MBChB
…tagenomic NGS (mNGS) has been applied in infectious disease diagnostics. Chang et al. have previously evaluated the use of mNGS in blood and urine samples for tuberculosis diagnostics. They revealed that such methodology is limited by the low MTB concentration and the background …
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Elin Folkesson
…nd post-treatment cure. These approaches could transform TB diagnostics, reduce diagnostic delays, and support global TB elimination efforts.</p><h3>List of scientific papers</h3><p dir="ltr">I. A protein signature associated with active tuberculosis ident…
Barkha Vimal, Saurabh Purohit, Albail Singh Yadav
Background: Abdominal tuberculosis (TB) remains a significant diagnostic challenge due to its nonspecific presentation and the limited sensitivity and specificity of conventional diagnostic modalities such as ultrasonography (USG) and contrast-enhanced computed tomography (CECT).…
Anvita Gupta Malhotra, Leena Lokhande, Abhijit Pakhare, Payal Soni, Satya Prakash Vishwakarma, et al.
… These findings advocate for integrating advanced molecular diagnostics into routine tuberculosis workflows to reduce diagnostic delays and improve patient outcomes. **CLINICAL TRAIL NUMBER:** Not applicable.
R. Nath, Pranav Ish, Kumari Harshita, Ashish Sethi
…acillary loads, which lower the sensitivity of conventional diagnostics.[7] AI models trained on diverse datasets may help detect subtle radiological or clinical patterns, thus improving case detection in this vulnerable subgroup. Molecular diagnostics are also being transformed …
Jorge E Leiva-Ordoñez, Beatriz Quintero
Tuberculous meningitis is the most severe form of tuberculosis and remains associated with high mortality and substantial neurological disability, particularly among children and people living with HIV. Early diagnosis is challenging because of nonspecific clinical manifestations…
Khalid Alyahyawi
…opic features, histopathological characteristics, molecular diagnostics, pharmacological therapy, and minimally invasive therapeutic interventions. Accurate diagnosis requires an integrated approach combining clinical assessment with imaging, endoscopic evaluation, and histopatho…
Meryem Sena Kaya, Sibel Yıldız Kaya, Rıdvan Karaali, Günay Can, İlker İnanç Balkan, et al.
**BACKGROUND:** Fever of unknown origin (FUO) remains a significant diagnostic challenge. Changes in patient populations and diagnostic technologies may shift the spectrum of underlying etiologies. This study aimed to examine recent FUO cases at a single tertiary center to identi…
Barış Çil, Mehmet Sinan Bodur, Mehmet Kabak
**BACKGROUND:** The diagnosis of extrapulmonary tuberculosis (EPTB) often depends on advanced imaging, invasive tissue sampling, and multidisciplinary referral pathways. These complex, procedure-dependent diagnostic processes are particularly vulnerable to disruption during perio…
Gustavo Tapia-Sequeiros, Miguel Hueda-Zavaleta, Juan Carlos Gómez de la Torre, Arantsa Hernandez-Vargas, Claudia Barletta-Carrillo, et al.
**BACKGROUND:** Motivation for the study. Peru has a high prevalence of tuberculosis, therefore, it is necessary to use diagnostic methods with high sensitivity and specificity to adequately identify cases and provide timely treatment. Main findings. Our results indicate that, wh…
All India Institute of Medical Sciences
The goal of this Diagnostic accuracy study is * To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and * To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical out…
Justin Onyebuchi Nwofe, Laura Madukaji, Daniel Chinenyeike Offie, Dickson Adeolu Adetoye, Emmanuel Adewale Ojo, et al.
Abstract Introduction Tuberculosis (TB) diagnosis remains the weakest link in the care cascade, particularly among people living with HIV and AIDS (PLHIV) with advanced HIV disease (AHD), who are often cannot produce quality sputum for standard tests. Urine-based assays such as D…
Tandel N, Joseph AZ, Joshi A, Shrama P, Mishra RP, et al.
…formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, …
Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, et al.
…et Product Profiles (TPPs) call for rapid, non-sputum-based diagnostics with high sensitivity and specificity. This study evaluates our previously published TB-associated host-immune biomarkers alongside small-size signatures from other studies, in our previously published non-hu…
Rangasamy Ramanthan, M. Jayapritha
…ngs, to improve TB detection. Expanding access to molecular diagnostics and integrating nutritional interventions are essential for better management.
Robert Needle, Yang Yu, Hafid Soualhine, Catherine Yoshida, Lei Jiao, et al.
…ycobacterial (NTM) infections is accomplished by three main diagnostics methods: smear microscopy, culture, and molecular testing. Diagnostic algorithms used by laboratories can significantly impact clinical and infection control management. Current Canadian Tuberculosis Standard…
Yuvarajan S, Praveen Radhakrishnan, Durga Krishnamurthy, Navya Cherukkumalli, Sagana Ravikumar
**BACKGROUND:** Sarcoidosis is a complex, multisystem granulomatous disease of unknown etiology, often presenting a diagnostic challenge due to its highly variable clinical manifestations and its overlap with infectious and neoplastic diseases. This is especially problematic in r…
Ganesh Kumar Verma, Muniba Alim, Ramesh Chand, Vinay Verma, Himanshu Gupta
BACKGROUND: Tuberculous meningitis (TBM) remains a leading cause of morbidity and mortality in children, particularly in endemic regions. Early diagnosis is crucial for optimal outcomes, yet remains challenging due to nonspecific clinical presentations and limited diagnostic sens…
Sara Benevento, Niccolò Riccardi, Giovanni Fumagalli, Luigi Ruffo Codecasa, Giovanni Sotgiu
Tuberculosis (TB) remains a leading cause of infectious-disease-related morbidity and mortality worldwide, including in low-incidence, high-income countries, where cases increasingly cluster among vulnerable populations. In these settings, persistent diagnostic and treatment dela…