Showing 1–25 of 65 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Raju R, Prasad BM, Alavadi U, Saini S, Sabharwal M, et al.
…has been transformed with the scaling-up of WHO-recommended diagnostics, but challenges remain with specimen transportation, completing diagnostic assessment, turnaround time (TAT), and maintaining laboratories. Private laboratories have demonstrated efficiencies for specimen col…
Heiman F Wertheim, PhD
Detection of M. tuberculosis in clinical specimens of children has a low sensitivity because specimens are either difficult to collect or contain low levels of M. tuberculosis. Diagnostic criteria are non-specific and culture confirmation is challenging, as sputum samples are not…
M R Marll, M Magee, N Glover, T Ngwanto, N Mofokeng, et al.
Abstract Rationale Approximately half of all tuberculosis (TB) survivors develop post-TB lung disease (PTLD), defined as persistent respiratory abnormalities despite a microbiological cure. Fibrosis, which typically presents as a restrictive ventilatory impairment on pulmonary fu…
Prince Malonda ma Ndungi, Blaise Idiamwana Kutokama, Bijou Masokolo Malamba, Dosithée Ngo-Bebe
Background Tuberculosis, the second deadliest infectious disease in the world after COVID-19, is caused by Mycobacterium tuberculosis. This bacterium most commonly affects the lungs. Economic and financial barriers can hinder access to healthcare services for the diagnosis and ma…
Hendra Subroto, Ida Parwati, Bachti Alisjahbana, Coriejati Rita, Yuhpita Indah Efriyani, et al.
There are still limitations in the diagnosis of tuberculosis (TB), and developing monitoring tools to predict treatment outcomes for TB patients is important. Sputum collection is not only challenging but also has low sensitivity when used as a diagnostic specimen. Interferon gam…
Agizew T, Boyd R, Auld AF, Payton L, Pals SL, et al.
Background Compared with smear microscopy, Xpert ® MTB/RIF has the potential to reduce delays in tuberculosis (TB) diagnosis and treatment initiation, and improve treatment outcomes. We reviewed publications comparing treatment outcomes of drug-susceptible TB patients diagnosed u…
Helena Rabie, Marieke M. van der Zalm
Rapid microbiological confirmation of Mycobacterium tuberculosis (M tuberculosis) in sputum with nucleic acid amplification tests (TB-NAAT) is an important step to diagnose tuberculosis and to identify possible drug resistance. These tests significantly increase the diagnostic yi…
Abdulrhman Awadh Alharbi, Ibrahim Muhammad Al-Arej, Abdullatif Suliman Alsayegh, Meshal Ibrahim Zaid Al Owias, Bader Sayah Alanezi
Background: Tuberculosis (TB) is a highly infectious disease with a long history of impacting global health. Despite the availability of effective treatments, TB remains a significant cause of morbidity and mortality, particularly in low- and middle-income countries and among HIV…
Adithya Cattamanchi, MD
As part of the ongoing efforts within the Rapid Research in Diagnostics Development for TB Network (R2D2 TB Network) study, the Candidate Clinical Correlate as Prognostic Outcome for TB (C3PO) study serves as a supplement aimed at evaluating predictors and novel biomarkers of rec…
Mbano IM, Mandizvo T, Rogich J, Kunota TTR, Mackenzie JS, et al.
…d lack of rapid, low-cost tuberculosis (TB) drug resistance diagnostics in low-income settings across the globe. It is these areas that are plagued with a disproportionately high disease burden and in greatest need of these diagnostics. Methods In this study, we compared the perf…
Digby F. Warner, Robin Wood
…ho is ill, and the development of improved point-of-care TB diagnostics remains a priority. Recent advances include expanding the GeneXpert molecular assay to detect multi-drug resistance [8], the use of whole-genome sequencing direct from clinical samples [9] and biomarker-based…
Mustafa Singapurwala, Poonam Gupta, Rohit Mishra, Amar Mandil, Swapnil Jain, et al.
…s early detection of DSTB and DRTB cases with the genexpert diagnostics, use of potent regimen and preventive care of household contacts. However, a simultaneous multi-dimensional uplift of socioeconomic, educational, nutritional status, personal health and hygiene etc., of the c…
Xiaoyun Du, Keqing Shi, Hao Zhang, Yingzhi Chong
Tuberculosis (TB) remains a leading global health threat, with the rise of drug-resistant (DR-TB) strains posing a significant impediment to disease control. An increasingly recognized and complex challenge is heteroresistance, the coexistence of drug-susceptible and drug-resista…
Irina Shabalina, Ilya Sivokozov, Dmitry Dedushkin, Tatyana Smirnova, Svetlana Shishova, et al.
<b>Aim:</b> To assess the rate of Detection Acid Fast Bacilli (AFB) in specimens of rEBUS and conventional bronchoscopy in comparison with another methods supporting diagnosis of pulmonary TB <b>Methods:</b> 176 patients (84 m and 92 f), aged 13-75 years, were undergoing bronchos…
Yu.O. Matviienko, О. M. Rekalova, V.М. Zhadan, S.H. Yasyr, А.В. Тараненко, et al.
OBJECTIVE. To study the diagnostic capabilities of integral hematological indices (IHI) in drug-sensitive tuberculosis (DSTB) after a previous coronavirus disease (COVID-19) under the influence of chronic stress caused by martial law. MATERIALS AND METHODS. A retrospective analys…
Chirenda J, Nhlema Simwaka B, Sandy C, Bodnar K, Corbin S, et al.
Background Insufficient cost data and limited capacity constrains the understanding of the actual resources required for effective TB control. This study used process maps and time-driven activity-based costing to document TB service delivery processes. The analysis identified th…
Nsawotebba A, Ibanda I, Mujuni D, Nabadda S, Nadunga D, et al.
Background Smear microscopy has remained the initial diagnostic test for presumptive tuberculosis (TB) patients in health facilities without the World Health Organization (WHO) recommended rapid diagnostic tools. In the Uganda TB laboratory network, the technique remains the only…
Carolina Ochôa Matos, João de Menezes Aguiar, Joaquim Polido‐Pereira, Elsa Vieira‐Sousa, João Janeiro, et al.
The patient, a 74-year-old man, presented with mechanical pain in left hip. He had previously undergone physiotherapy, which was discontinued five months earlier following suspicion of a gluteal hematoma. He also reported a 9-kg weight loss over a year. Pelvic x-ray revealed eros…
Wilber Sabiiti, Emmanuel Musisi, Bariki Mtafya, Peter M. Mbelele, Khalide Azam, et al.
<h3>Background</h3> Tuberculosis (TB) treatment is long and complex. Here we summarise data from EDCTP-funded studies of the Tuberculosis Molecular Bacterial Load Assay (TB-MBLA) as a TB treatment monitoring tool. <h3>Methods</h3> Treatment naïve participants from four Sub-Sahara…
Dutta NK, Tornheim JA, Fukutani KF, Paradkar M, Tiburcio RT, et al.
…) remains a major global health problem. Improved pediatric diagnostics using readily available biosources are urgently needed. We used liquid chromatography-mass spectrometry to analyze plasma metabolite profiles of Indian children with active TB (n = 16) and age- and sex-matche…
Kranti Garg
The discrimination and social isolation associated with the contagiousness of the disease prevents the patient and his family members from accepting the diagnosis, disclosing it to the people around and seeking health care. The heterogeneity in behavioral responses spans from psy…
Sarah Schmidiger, Damien Portevin
…of death from a single-infectious agent. Improved vaccines, diagnostics and treatment regimens for drug-susceptible and drug-resistant cases are paramount to attain the goals of the WHO's End TB Strategy. Our knowledge gap in protective immunity in TB impedes the development of s…
Ang MLT, Chan SM, Cheng LT, Cheong HY, Chew KL, et al.
…new advances in the clinical management of TB, ranging from diagnostics to new drugs and treatment regimens. The National TB Programme convened a multidisciplinary panel to update guidelines for the clinical management of drug-susceptible TB infection and disease in Singapore, co…
Khaing MNT, U N, Maw L, Arkar H, Naing SPP, et al.
Background The financial burden of tuberculosis (TB) can hinder patients and their families, creating obstacles throughout the care cascade, despite TB prevention and control being provided free of charge. In Myanmar, patients can visit private providers operating under public-pr…
Villalva-Serra K, Barreto-Duarte B, Miguez-Pinto JP, Queiroz ATL, Rodrigues MM, et al.
…s expanded use and further research into advanced molecular diagnostics for effective TB and DR-TB control. Funding FIOCRUZ.