Showing 1–25 of 102 documents
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Azar Najafi, Nahid Mahdian, Bahman Yousefi, Mohsen Karbalaei, Ali Kermanjani, et al.
…d in vivo examinations, such as recombinant BCG (rBCG), DNA vaccines, and subunit vaccines. Factors, such as applicability of vaccine candidates in all individuals, cost-effectiveness, long-term immunity and stimulation of a wide range of responses are important factors. Now, mos…
Jeyachandran DS, Pusam Y
…how these insights could catalyze the development of future vaccines. The current landscape of novel vaccine development for TB is illuminated, including a spotlight on the latest vaccine candidates.
Yue Wang, Weibing Wang
…, treatments, and innovative tools such as new tuberculosis vaccines are urgently needed. Although there have been rapid advances in tuberculosis vaccine clinical research over the past decade, mathematical modelling studies, which can provide a method to predict the potential fu…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
… for increasing access to affordable drugs, diagnostics and vaccines for other epidemic diseases affecting resource-poor countries. In April, 2021, a Brazil judge suspended drug patent extensions, a preliminary decision that could lower costs for drugs critical to treating COVID-…
Srivastava S, Dey S, Mukhopadhyay S
…nd impacted by the inefficacy of drugs, absence of advanced vaccines, misdiagnosis improper treatment, and social stigma. The BCG vaccine provides partial effectiveness in demographically distinct populations and the prevalence of multidrug-resistant (MDR) and extensively drug-re…
Anne Margarita Dyrhol-Riise, PhD
…itors (COX-2i) can improve the immune system and strengthen vaccines responses. Hypothesis 1. A hyperactive COX-2/PGE2 signal system in active TB causes down-regulated immune responses that favour TB survival, but this can be abrogated by COX-2i. 2. TB-specific immunisation wit…
Bidyarani Devi Konjengbam, Heikrujam Nilkanta Meitei, Anupama Pandey, Reena Haobam
… and its preclinical and clinical trials. Additionally, DNA vaccines and their vaccination techniques are also discussed. Furthermore, the immunoinformatics approach and nanomaterial-based vaccine delivery with practical and productive endpoints are also discussed. Lastly, the po…
Naomi E. Aronson, MD, Merlin L. Robb, MD
The purpose of this research is to find out if a single dose of pre-travel vaccination with BCG can lessen tuberculosis (TB) infection by producing an immune response when given to adults traveling to countries with a high or moderate burden of TB. BCG will be compared with a pla…
Divya Goswami, Gautam Kalwadia, Kunal Saini, Anita Sondhi
… of TB, necessitating the importance of better and improved vaccines. The emergence of drug-resistant TB, like MDR-TB (multidrug-resistant TB and XDR-TB (extensively drug-resistant TB, has made the situation even more serious. Nearly nineteen new TB vaccines are in clinical trial…
Khan MT, Mahmud A, Islam MM, Sumaia MSN, Rahim Z, et al.
…culosis. Therefore, it is urgently necessary to develop new vaccines to prevent infections caused by these strains. We used a subtractive proteomics approach on 23 virulent Mtb strains and identified a conserved membrane protein (MmpL4, NP_214964.1) as both a potential drug targe…
Ahmed M, Farris E, Swanson RV, Das S, Yang Y, et al.
…s, there is an urgent need for the design of more effective vaccines against TB. The development of safe and novel adjuvants for human use is critical. In this study, we demonstrate that saponin-based TQL1055 adjuvant when formulated with a TLR4 agonist (PHAD) and Mtb specific im…
Chae H, Shin SJ
…e Mtb complex strains are required for development of novel vaccines and for control of MDR/XDR Mtb infection, eventually leading to refinement of treatment regimens and the health care system. Many studies have focused on the differential identification of Mtb complex strains be…
Shantong Liu, Qianqian Zhang, Siqi Lin, Qiaoyu Yang, Jiang Pi, et al.
…the urgent need for novel treatment strategies. Therapeutic vaccines, an innovative immunotherapeutic approach, are designed to be administered alongside standard pharmacological treatments. By enhancing pathogen-specific immune responses in the host, these vaccines aim to eradic…
Mohammadzadeh R, Ghazvini K, Farsiani H, Soleimanpour S
…m, which emphasises the design and development of efficient vaccines and diagnostic biomarkers. Extracellular vesicles (EVs) secretion is a conserved phenomenon in all the domains of life. Various cargos such as nucleic acids, toxins, lipoproteins, and enzymes have been recognise…
Mata-Espinosa D, Lara-Espinosa JV, Barrios-Payán J, Hernández-Pando R
…nary Mtb transmission to close contacts. We also review new vaccines that deliver Mtb antigens via particle- or virus-based vectors and trigger protective immune responses. The results obtained in this type of research suggest that this is an alternative therapy that has the pote…
Fang Y, Wang F, Jiang T, Duan J, Huang T, et al.
Mpox is a zoonotic infectious disease caused by the mpox virus (MPXV). Historically, the majority of mpox cases have been documented in Central Africa. However, since May 2022, there has been a notable rise in reported cases from regions beyond Africa. Currently, over 110 countri…
Nadia A. Sam‐Agudu, Chandy C. John
…e Tracker TeamCOVID-19 vaccine tracker.https://covid19.trackvaccines.org/Date: 2022Google Scholar Furthermore, while COVID-19 vaccine coverage in the United States is >20% for 5–11 year olds and approaching 60% for 12–17 year olds,4US Centers for Disease Control and PreventionCOV…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
… and to conduct research on new diagnostics, treatments and vaccines required to achieve global TB control (Tiberi et al., 2018Tiberi S. Petersen E. Maeurer M. Ntoumi F. Yeboa-Manu D. Mwaba P. et al.Taking forward the Stop TB Partnership and World Health Organization Joint Theme …
Elwira Sieniawska
…n a reduction in funding for tuberculosis treatment and BCG vaccines in children. The COVID-19 pandemic outbreak in 2020 disrupted essential health services and placed an additional burden on people with tuberculosis (World Health Organization, Global Tuberculosis Report, 2021). …
Ambuj Kumar Kushwaha, Abhisheka Bansal, Gunjan Arora, Divya Kushwaha
…echanisms of action, identify new drug targets, and enhance vaccines and diagnostic tools (Basore et al., 2015; Kushwaha et al., 2018; Matteucci et al., 2022). This Frontiers in Cellular and Infection Microbiology Research Topic, "Mechanisms Driving Drug Resistance in Tuberculosi…
David S.C. Hui, Chi Chiu Leung
…el TB vaccine candidates being developed include whole-cell vaccines, adjuvanted protein vaccines, viral vaccines, vaccines, are as a in diseases they are more on a population Unlike the protective effects of will not be by after the However, with the high global burden of latent…
Cynthia Bin Eng Chee, David S.C. Hui
… continue to be important. The availability of pneumococcal vaccines and multiplex polymerase chain reactions (PCR) has led to a decreasing incidence of pneumococcal pneumonia and detection of more viral aetiologies in CAP. In recent years, rapid and automated molecular tests bas…
Ahmed Al Hammadi, Fatima Ali Salem Khalfan Al Dhaheri, Huda Sulaiman Al Dhanhani, Jens Thomsen
…on had been vaccinated with at least one dose of a COVID-19 vaccines, resulting in a mortality rate of only 0.24%, making it one of the lowest in the world.
Stefan H. E. Kaufmann
…ails to protect against pulmonary TB in all age groups. New vaccines against TB are urgently needed. New candidates that have entered clinical trials are killed whole cell vaccines, recombinant live vaccines, Mtb antigen-adjuvant formulations or viral vectors expressing Mtb antig…
Taru S. Dutt, Burton Karger, Amy Fox, Nathan Youssef, Rhythm Dadhwal, et al.
… because of the inadequacy of currently available drugs and vaccines. The most common clinical manifestation is pulmonary TB, and the Bacille Calmette Guerin (BCG) is the only licensed vaccine for protection against TB; however, its efficacy is highly variable. Today at least 52 …