Showing 1–25 of 184 documents
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Daifulah Al-Zahrani
Tuberculosis (TB) is considered by WHO as a worldwide wellbeing crisis in 1993. In 2011 33% of the total populace was believed to be contaminated with TB and 8.7 million instances of dynamic TB every year. BCG antibody is one of the successful control measures to forestall TB. It…
Helen McShane, Dr
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines, recombinant viral vectors and protein/adjuvant combinations all induce both CD4+ and CD8+ T cells, however none of these antigen delivery systems induce high levels of antigen specific T cells, wh…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
François Spertini
…t" vaccination strategies, in which two different candidate vaccines expressing antigens in common are given weeks or months apart, have generated strong and sustained cellular immune responses correlating with an M.tb protective effect in preclinical animal models. In such a "pr…
Mark Hatherill, MD, FCPaed
…as been excluded. Clinical trials of new viral-vectored TB vaccines, including MVA85A, a modified vaccinia virus Ankara (MVA) vaccine expressing the Mycobacterium tuberculosis antigen 85A, have to date enrolled infants who were already vaccinated with routine BCG at birth. Howev…
Teljeur C, Moran PS, Harrington P, Butler K, Corcoran B, et al.
Background In Western Europe, currently only Ireland and Portugal continue to provide universal neonatal bacillus Calmette-Guérin (BCG) vaccination programs, despite not being considered as high tuberculosis (TB) incidence countries. Other European countries only vaccinate infant…
Martinez L, Cords O, Liu Q, Acuna-Villaorduna C, Bonnet M, et al.
Background BCG vaccines are given to more than 100 million children every year, but there is considerable debate regarding the effectiveness of BCG vaccination in preventing tuberculosis and death, particularly among older children and adults. We therefore aimed to investigate th…
Nieuwenhuizen NE, Zyla J, Zedler U, Bandermann S, Abu Abed U, et al.
BCG - the only available vaccine against tuberculosis (TB) - was first given to babies 100 years ago in 1921. While it is effective against TB meningitis and disseminated TB, its efficacy against pulmonary TB is variable, notably in adults and adolescents. TB remains one of the w…
Anna Starshinova, Igor Kudryavtsev, Artem Rubinstein, Irina Dovgalyuk, Anastasia Kulpina, et al.
Tuberculosis (TB) remains a fatal disease primarily transmitted through airborne droplets, with children who are the most susceptible, particularly in the areas with poor tuberculosis control. The BCG vaccine, developed by Albert Calmette and Camille Guérin, has a history sp…
Rajesh Kumar Radhakrishnan, Abhinav Vankayalapati, Olamipejo Durojaye, Padmaja Paidipally, Ramakrishna Vankayalapati
…o adults. Funding Sources NIH, CRDF Global Topic Categories Vaccines and Immunotherapy (VAC)
Liao Q, Zheng Y, Wang Y, Ye L, Liu X, et al.
Background Evidence varies regarding the efficacy of Bacillus Calmette-Guérin (BCG) vaccine. Data on protection by BCG vaccination against severe tuberculosis (TB) among children in China remain unclear. Methods We conducted a case-based, multicenter retrospective study at three …
O'Hara JM, Wakabayashi S, Siddiqi N, Cheung E, Babunovic GH, et al.
…ainst lung disease. Thus, there is an urgent need for novel vaccines. Here, we show that a multicomponent acellular vaccine (TB-MAPS) induces robust antibody responses and long-lived systemic and tissue-resident memory Th1, Th17, and cytotoxic CD4 + and CD8 + T cells, and promote…
Chiara Tersigni, Luisa Galli
…bMed Scopus (13) Google Scholar]. Up to now, several new TB vaccines are in the pipeline with incomplete results regarding safety and efficacy in the pediatric age [[9]Schrager L.K. Vekemens J. Drager N. et al.The status of tuberculosis vaccine development.Lancet Infect Dis. 2020…
Yang Y, Chen YZ, Xia T
…. Consequently, the exploration and development of novel TB vaccines, capable of providing broad protection to populations, have consistently constituted a prominent area of interest in medical research. This article presents a concise overview of the novel TB vaccines currently …
Dženan Kovačić, Adna Softić, Adna SALIHOVIĆ, Jovana Jotanović, Sarah Maris Hotić
…file across a wider population. To this end, the novel mRNA vaccines were proven to elicit immune responses against bacterial pathogens; by virtue, the technology may be applied in bacterial infection treatment. Meanwhile, no approved mRNA prophylactics for bacterial infections e…
Thomas E. Tavolara, Muhammad Khan Niazi, Gillian Beamer, Metin N. Gürcan
Individual factors that lead to susceptibility to Mycobacterium tuberculosis infection among humans and animal models are not clearly defined. As a result, clinicians and scientists have little ability to diagnose and prognose the various clinical manifestations of tuberculosis, …
Tsujimura Y, Shiogama Y, Soma S, Okamura T, Takano J, et al.
…ogy that are used routinely to determine the efficacy of TB vaccines in nonhuman primate models might not correlate with the bacterial burden and histopathological score in the lung as measured in this study.
Videlis Nduba
…evere adverse effects in immunocompromised individuals. New vaccines are key to the global effort to eliminate TB. New vaccines will need to protect against pulmonary, extrapulmonary and disseminated TB in all populations and are urgently needed. A vaccine strategy that targets a…
Muhammad Abdir Rahman Albarok, Muhammad Faris, Anang Endaryanto, Retno Asih Setyoningrum
Highlights: The Bacillus Calmette-Guérin (BCG) vaccination has been widely implemented in Indonesia, but cases of spinal tuberculosis (TB) in children can still be found. There are significant and moderate relationships between BCG vaccination and the occurrence of spinal TB in c…
Usama Sajjad, Khalid Khan Niazi, Gillian Beamer, Metin N. Gürcan
Tuberculosis (TB), caused by <i>Mycobacterium tuberculosis</i> (M.tb), poses a substantial global health challenge, affecting over 2 billion individuals worldwide. Although the approved vaccine against TB, <i>M. bovis</i> Bacille Calmette-Guerin (BCG), successfully prevents TB me…
Koster KJ, Webb HL, Cirillo JD
Bacille Calmette-Guérin (BCG) vaccination, widely used throughout the world to protect against infant tuberculous meningitis and miliary tuberculosis (TB), can provide broad non-specific protection against infectious respiratory diseases in certain groups. Interest in BCG has see…
Muhammad Yasir, Khalid Basheer, Bilal Aslam, Marium Faiz
…anufacturer. Ascertaining the relative effectiveness of BCG vaccines from different producers may have implications when setting national and global policy, as use of strains that offer superior protection may be more cost-effective
Bibi Aalia, Syed Sajid Hussain Shah
OBJECTIVE: To assess for the neurological complications and Bacille Calmette-Guerin (BCG) vaccination status of children with tuberculosis meningitis (TBM). METHODS: This retrospective study was conducted in Ayub Teaching Hospital, Abbottabad, Pakistan. Data of diagnosed case of …
Aceves-Sánchez MJ, Flores-Valdez MA, Pedroza-Roldán C, Creissen E, Izzo L, et al.
A single intradermal vaccination with an antibiotic-less version of BCGΔBCG1419c given to guinea pigs conferred a significant improvement in outcome following a low dose aerosol exposure to M. tuberculosis compared to that provided by a single dose of BCG Pasteur. BCGΔBCG1419c wa…
Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, et al.
…Mtb), but the optimal T-cell antigens to be included in new vaccines are not established. T-cells are often thought of as responding mainly to peptide antigens presented by polymorphic major histocompatibility complex (MHC) I and II molecules. Over the past two decades, the numbe…