Showing 1–22 of 22 documents
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Piamlarp Sangsayunh, Thanyanuch Sanchat, Charoen Chuchottaworn, Krisana Cheewakul, Sirijit Rattanawai
…eated with BPaL regimen, while the remainder received BPaLM regimens. RESULTS: Among the 28 patients, 23 (82.1 %) successfully completed the treatment with favorable outcomes. However, one patient from the BpaL regimen died due to severe destroy lung lesion, and four patients fro…
E. S. Ovsyankinа, Л. В. Панова, E. A. Krushinskaya, М. А. Багиров
…e: to evaluate the effectiveness of short-curse chemotherapy regimens for treatment of MDR/pre-XDR tuberculosis in combination with surgery in older children and adolescents. Subjects and Methods. 51 patients with MDR/pre-XDR respiratory tuberculosis aged 13-17 years were enrolled…
М.В. Ураксина, E. P. Еremenko, Е. А. Бородулина, B. Borodulin
The main problem in the treatment of tuberculosis (TB) patients is the increase in drug resistance of M.tuberculosis, which is not always detected at the start of chemotherapy, which leads to inadequate and lengthy treatment. Research objective . Analysis of the treatment of newl…
Rizvan Abdullaev, A. M. Tikhonov, V. A. Shorokhova, О. Г. Комиссарова
The objective : assessment of changes in the parameters of complete blood count, clinical urine tests, and blood chemistry during chemotherapy of patients with MDR/XDR pulmonary tuberculosis receiving the short-course regimen containing bedaquiline, pretomanid, and linezolid (B-P…
R Santosh
Introduction: Drug-resistant tuberculosis is a major public health problem throughout world. India accounts for 27% of global TB burden. More than half of TB patients in India are cared for in private sector. Usage of inappropriate TB diagnostic, treatment practices and lack of a…
Gopalaswamy R, Palani N, Viswanathan D, Preysingh B, Rajendran S, et al.
… SL-DR patients were initiated on different DR-TB treatment regimens and monitored for their outcomes. The objective of this retrospective analysis was to understand the mutation profile and treatment outcomes of SL-DR patients. Materials and Methods : A retrospective analysis of…
Podlekareva DN, Folkvardsen DB, Skrahina A, Vassilenko A, Skrahin A, et al.
…urden settings. Carefully designed individualized treatment regimens in accordance with DST patterns will likely improve patients' outcome and reduce transmission with drug-resistant Mycobacterium tuberculosis strains.
Arash Ghodousi, Alamdar Hussain Rizvi, Aiman Baloch, Abdul Ghafoor, Faisal Masood Khanzada, et al.
…g-resistant-tuberculosis patients on bedaquiline-containing regimens were retrospectively tested for bedaquiline resistance by MIC testing in 7H11 medium, and for all isolates showing an increased MIC compared to the baseline isolate, further MIC testing for bedaquiline and clofa…
А. I. Gayda, A. V. Abramchenko, M. I. Romanova, T. V. Toichkina, V. S. Burykhin, et al.
…n Federation and they started a course of chemotherapy with regimens containing Lzd and Bdq in 2017-2018. All patients who interrupted their chemotherapy (124) were divided at 4 groups. Group 1-43 patients who received less than 90 doses, Group 2-37 patients who received from 91 …
Rajesh Kumar Yadav, Hari Prasad Kaphle, Dipendra Kumar Yadav, Suman Chandra Gurung, Elina Khatri, et al.
Introduction: Poor adherence to the treatment regimen is a major cause of treatment failure and the emergence of drug resistance among TB patients. The emergence of resistance to anti-tuberculosis drugs and particularly of multi-drug resistance (MDR), Pre-extensively drug resista…
А. В. Мордык, О. Г. Иванова, S. V. Sitnikova, V. I. Gusina, A. O. Ptukhin
…y inclusion of new anti-tuberculosis drugs in the treatment regimens of patients. drugs. Aim . To evaluate the efficacy and safety of bedaquiline in the complex treatment of patients with HIV-associated respiratory tuberculosis. Materials and methods . In the prospective study wa…
Radhika R, Tullu MS, Shamla O, David J
Abstract Tuberculosis as cause of mediastinal mass, is rare in children, and may be seen in immunodeficiencies. Data on the prevalence of mediastinal tuberculosis and on its clinical spectrum and outcome is lacking in children. A 4.5-month-old boy presented with fever and cough s…
Lindiwe Modest Faye, Mojisola Clara Hosu, Ntandazo Dlatu, Vatiswa Henge-Daweti, Teke Apalata
…tion of ototoxicity risk factors can inform safer treatment regimens and improve patient outcomes in resource-limited settings.
Katran ZY, Bulut İ, Babalık A, Keren M, Tepetam FM, et al.
Objective To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods This was a retrospective study. The primary aim of the study is to determine the demographic and clinical characteristics of patients who develop drug …
Jantarabenjakul W, Supradish Na Ayudhya P, Suntarattiwong P, Thepnarong N, Rotcheewaphan S, et al.
Background The prevalence of drug-resistant tuberculosis (DR-TB) in adults has stabilized in the past decade. Our study aimed to describe the prevalence of DR-TB in Thai children between 2006 and 2021. Materials and methods Children younger than 15 years old who had culture-confi…
Liang Z, Liao W, Chen Q, Li H, Ye M, et al.
Drug-resistant tuberculous meningitis (TBM) is the most devastating and critical form of extrapulmonary tuberculosis. Here, we present a case of a 45-year-old male with pre-extensive drug-resistant tuberculosis meningitis (pre-XDR-TBM). He underwent emergency surgery for the long…
Gupta M, Ish P, Malhotra N
The recent guidelines on the Programmatic Management of Drug-Resistant Tuberculosis (DR-TB) in India (PMDT) have been released in March 2021 on World TB Day. The new guidelines have considered emerging diagnostic trends including TrueNat, Xpert Mtb/XDR, Next generation sequencing…
Saeed DK, Shakoor S, Razzak SA, Hasan Z, Sabzwari SF, et al.
Background Mutations in the Rv0678, pepQ and atpE genes of Mycobacterium tuberculosis (MTB) have been reported to be associated with reduced antimycobacterial susceptibility to bedaquiline (BDQ). Resistance conferring mutations in treatment naïve MTB strains is likely to have imp…
Richmond Ronald Gomes
Abstract: Cervical-TB lymphadenitis is the most frequent extrapulmonary manifestation of tuberculosis infection. There are limited documents on multidrugresistant cervical tubercular lymphadenitis, but there is no evidence which may occur in TB endemic regions. Multidrug-resistan…
S. V. Sklyuev, Е. М. Жукова, N. V. Stavitskaya
The article describes a clinical case of a female patients with the continuous course of tuberculosis (more than 14 years). Despite the ongoing anti-tuberculosis therapy, the use of all possible surgical methods including valvular bronchial blocking, bacterial excretion persisted…
Yu. D. Mikhailova, Marina Makarova, L. Yu. Krylova, S. G. Safonova, В. И. Литвинов
…logies, e.g. clofazimine, in anti-tuberculosis chemotherapy regimens. The aim was to determine the phenotypic sensitivity to clofazimine of clinical strains of MTB with different spectrum of drug resistance. Methods . Clofazimine sensitivity was studied for 75 MTB clinical strain…
MEH Mohamed, MM Mukhtar, ME Hamad, AA Daffalla
…ss among those living in rural areas to available treatment regimens and improve disease perception to increase treatment compliance and adherence.The study findings highlighted the importance of training of health providers on the proper recording and maintenance of all MDR-TB c…