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Abidi S, Achar J, Assao Neino MM, Bang D, Benedetti A, et al.
…tiveness of two World Health Organization (WHO)-recommended regimens for the treatment of rifampin- or multidrug-resistant (RR/MDR) tuberculosis (TB): a standardised regimen of 9-12 months (the "shorter regimen") and individualised regimens of ≥20 months ("longer regimens").We co…
Park HY, Kwon JW, Kim HL, Kwon SH, Nam JH, et al.
Background Regimens for the treatment of multidrug-resistant tuberculosis (MDR-TB) have been changed from injectable-containing regimens to all-oral regimens. The economic effectiveness of new all-oral regimens compared with conventional injectable-containing regimens was scarcel…
Budak M, Cicchese JM, Maiello P, Borish HJ, White AG, et al.
…ng more effective and more patient-friendly antibiotic drug regimens to increase patient compliance and decrease emergence of resistant TB. Moxifloxacin is one promising antibiotic that may improve the current standard regimen by shortening treatment time. Clinical trials and in …
Happiness Cornel Mvungi, Peter Masunga Mbelele, Kassim Salim Msaji, Stellah George Mpagama, Hadija Hamis Semvua
… Health Organization recommended all-oral bedaquiline-based regimens, but evidence comparing their effectiveness to injectable-containing regimens is limited. This study evaluated treatment success between both approaches. **METHODS:** This was a retrospective study, which inclu…
Zainabadi K, Vilbrun SC, Mathurin LD, Walsh KF, Pape JW, et al.
…g-resistant tuberculosis (DR-TB). How these new second-line regimens fare in comparison to first-line regimens for treatment of drug-sensitive tuberculosis (DS-TB) is not well known. Methods In this study, we contemporaneously enrolled subjects with DS-TB (n = 31) or DR-TB (n = 2…
Jie Tan, Jun Huang, Jin Wang
…dy aimed to evaluate the efficacy of bedaquiline-containing regimens versus conventional regimens for cavitary MDR-PTB based on CT imaging. This retrospective study included 100 patients with cavitary MDR-PTB treated from June 2023 to June 2025. Patients were divided into a Conve…
Ashwin Karnan, Ulhas Jadhav, Babaji Ghewade, Vivek Alone
…reatment. Evaluating the effectiveness of various treatment regimens is crucial for identifying the best balance among treatment duration, efficacy, adverse drug effects, and patient adherence. A prospective, observational study on 50 MDR-TB patients was carried out at a tertiary…
Jefman Efendi Marzuki HY, Nafrialdi N, Sawitri N, Sugiri YJ, Gusti Agung Ayu Putu Sri Darmayani I, et al.
…DR-TB patients on DLM regimen compared to shorter treatment regimens (STR). Methods A retrospective cohort was implemented on secondary data obtained from two participating hospitals. The QTc interval and the changes in QTc interval from baseline (ΔQTc) were assessed every 4 week…
Seyed Saeed Hashemi Nazari, Saeid Fallah, Vahideh Raeisi
Context The number of tuberculosis (TB) patients and multidrug-resistant species of Mycobacterium tuberculosis are increasing worldwide. Effective treatment is still the key factor to control TB in the society. Aims The aim of the study was to compare the efficacy of fixed-dose c…
World Health Organization
Courtney M. Yuen, Moorine Sekadde, Brian Kaiser, Brenda Waning, Stephen M. Graham
…for TB disease or infection, the length of common treatment regimens poses a challenge to the implementation of child-friendly TB care. Undergoing TB disease treatment, which previously ranged from 6 months for drug-sensitive TB to up to 2 years for multidrug-resistant TB (MDR-TB…
Sarah Meredith, MD, Andrew Nunn, PhD
… the rise, there is a need to investigate optimal treatment regimens using effective drugs. The STREAM study is an international, multi-centre, parallel-group, open-label, randomised, controlled trial in patients with multi-drug resistant tuberculosis (MDR-TB) including patients…
Rosu L, Madan JJ, Tomeny EM, Muniyandi M, Nidoi J, et al.
…he STREAM stage 2 trial assessed two bedaquiline-containing regimens for rifampicin-resistant tuberculosis: a 9-month all-oral regimen and a 6-month regimen containing an injectable drug for the first 2 months. We did a within-trial economic evaluation of these regimens. Methods …
Sedona Sweeny
…iming to assess the costs to patients and providers of such regimens and to estimate the cost-effectiveness and poverty impact of an introduction of new MDR-TB regimens in the three countries participating in the main study. Multidrug resistant tuberculosis (MDR TB), tuberculosi…
Goodall RL, Nunn AJ, Meredith SK, Bayissa A, Bhatnagar AK, et al.
…round STREAM stage 2 showed that two bedaquiline-containing regimens (a 9-month all-oral regimen and a 6-month regimen with 8 weeks of aminoglycoside) had superior efficacy to a 9-month injectable-containing regimen for rifampicin-resistant tuberculosis up to 76 weeks after rando…
Gu P, Lu P, Ding H, Liu Q, Ding X, et al.
…ound To compare the effectiveness, cost, and safety of four regimens recommended by the World Health Organization (WHO) for rifampicin resistance/multidrug-resistance tuberculosis (RR/MDR-TB) Treatment in Eastern China. Methods We performed a cohort study among patients with RR/M…
Kwonjune J. Seung, Cathy Hewison
…rug-resistant tuberculosis to more effective and safer drug regimens that avoid debilitating side-effects, such as permanent hearing loss.2Farmer PE Better and safer treatment for multidrug-resistant tuberculosis.Lancet. 2018; 392: 798-800Summary Full Text Full Text PDF PubMed Sc…
Danyuchen Sun, Zhili Li, Yingpeng Qiu, Wei Shu, Lijie Zhang, et al.
…valuate the cost-effectiveness of two novel drug containing regimens compared to traditional regimen in Chinese adult population. **METHODS:** We performed a cost-effectiveness analysis from the perspective of the patient. Clinical treatment information and outcomes were retrosp…
N.А. Lytvynenko, Y. I. Feschenko, Maryna Pogrebna, A.S. Lapheta, L.V. Shcherbakova, et al.
…iveness of various shortened standard or modified treatment regimens for patients with multidrugresistant tuberculosis. Materials and methods. A prospective observational study was carried out to study different shortened AMBT regimens for 346 patients with multidrug-resistant t…
Tari Nur Fauziyantini, Umi Yuniarni, Lanny Mulqie
…since 2023, Indonesia has implemented several TB-RO therapy regimens, namely BPaLM (6 months), BPaL (6 months), 9 month regimen, and long-term regimen (18-24 months). The choice of regimen is based on the patient's condition, treatment history, and level of resistance to certain …
Nsengiyumva NP, Campbell JR, Oxlade O, Vesga JF, Lienhardt C, et al.
…r, and cheaper tuberculosis (TB) preventive treatment (TPT) regimens will enhance uptake and effectiveness. WHO developed target product profiles describing minimum requirements and optimal targets for key attributes of novel TPT regimens. We performed a cost-effectiveness analys…
Ding Y, Zhu H, Fu L, Zhang W, Wang B, et al.
…after 8 weeks). In conclusion, oral short-course three-drug regimens, including TBI-166 with high efficacy, were identified. The TBI-166+BDQ+PZA regimen is recommended for further study in a TBI-166 phase IIb clinical trial.
R. Swapna, Karanth M P Swathi, M. Somashekar, Asit Kumar Chakraborty, J.S. Akshata, et al.
…entional longer regimen. Evaluating the performance of both regimens in a programmatic setting will help in tailoring the treatment regimen of MDR-TB. Objectives: To estimate the duration of sputum smear conversion in the shorter MDR-TB regimen. 2. To compare the treatment outcom…
Innocent Murhula Kashongwe, Leopoldine Mbulula, Fina Mawete, Nicole Anshambi, Nadine Maingowa, et al.
…w approach improved favorable outcomes. Both short and long regimens reached a high level of favorable outcome compared to the previous study. The short regimen, well supervised seems to be superior to the long regimen in term of Death rate and loss to follow up (LTFU).
Kohler S, Sitali N, Achar J, Paul N
…hs), 10 shorter (9-12 months), and 8 short (≤6 months) drug regimens for drug-sensitive (DS) and multidrug-resistant (MDR)-TB treatment. Costs per regimen were estimated by multiplying recommended drug amounts with 2021 Global Drug Facility prices and drug import costs of a TB pr…