Showing 176–200 of 200 documents
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GBD 2023 Vaccine Coverage Collaborators
…ne coverage; (2) we forecast coverage of select life-course vaccines up to 2030; and (3) we analyse progress needed to reduce the number of zero-dose children by half between 2023 and 2030. **FINDINGS:** Overall, global coverage for the original EPI vaccines against diphtheria, …
Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, et al.
Immunotherapy for cervical cancer should target high-risk human papillomavirus types 16 and 18, which cause 50% and 20% of cervical cancers, respectively. Here, we describe the construction and characterization of the pBI-11 DNA vaccine via the addition of codon-optimized human p…
Fabiola Silva-Angulo, Henao-Tamayo, Marcela, Weir, Tiffany, Abdo, Zaid, Izzo, Angelo
Tuberculosis is an infectious lung disease responsible for approximately 1.4 million human deaths, world-wide every year. The causal agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), has been estimated to latently infect one-third of the human population. Curre…
Renee Gresh, Kimberly Davidow, Jeff Myers, D Morley
Abstract Introduction: It is well known that children with cancer are at an increased risk of severe influenza infections due to immunosuppression and co-morbidities. Serious influenza infections can lead to increased hospitalizations, outpatient visits, and delays in treatment. …
Sanami S, Rafieian-Kopaei M, Dehkordi KA, Pazoki-Toroudi H, Azadegan-Dehkordi F, et al.
…ed. There are currently commercially available prophylactic vaccines that have been shown to protect vaccinated individuals against HPV infections, however, these vaccines have no therapeutic effects for those who are previously infected with the virus. The current study's aim wa…
Cholewik M, Stępień M, Bieńkowski C, Pokorska-Śpiewak M
Background: Russia's aggression against Ukraine in early 2022 resulted in a large migration of refugees to many countries, including Poland. Vaccination coverage for some infectious diseases in Ukraine is lower than in Poland; consequently, the incidence of infectious diseases-in…
Viktoria A. Minaeva, Alla A. Golubkova
BACKGROUND: Reducing population immunity to vaccine-controlled infections because of low vaccination coverage at any moment could destabilize earlier epidemiological well-being against vaccine-controlled infections in the context of the COVID-19 pandemic. AIM: This study comprehe…
Meskell P, Biesty LM, Dowling M, Roche K, Meehan E, et al.
…ential risks and benefits associated with rapidly developed vaccines. Objectives To explore the factors that influence a person's decision to participate in a vaccine trial in the context of a pandemic or epidemic. Search methods We used standard, extensive Cochrane search method…
National Institute of Allergy and Infectious Diseases (NIAID)
This study will assess the safety of a Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis (TB) and will evaluate if giving the vaccine by mouth, injection, or by both methods produces greater results. BCG vaccine and/or placebo (substance containing no medication) will b…
Tameris M, Mearns H, Penn-Nicholson A, Gregg Y, Bilek N, et al.
…nd Infants are a key target population for new tuberculosis vaccines. We assessed the safety and immunogenicity of the live-attenuated Mycobacterium tuberculosis vaccine candidate MTBVAC in adults and infants in a region where transmission of tuberculosis is very high. Methods We…
Yang Liu, Yuanyuan Zhang, Ning Yao, Zhiyong Zhang, Qing Wang, et al.
…ment information as well as the vaccination records of live vaccines. Two stool samples were collected for virus detection and the vaccine-derived poliovirus was analyzed. A total of 26 primary immunodeficiency patients were enrolled among 3312 monitored cases, including 5 cases …
Joann Diray‐Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S. Kelly, et al.
Summary Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology, including metabolomics, enables new characterization of vaccine mechanisms of action, these tools have yet to be applied to infants at high risk of infectio…
Folegatti PM, Jenkin D, Morris S, Gilbert S, Kim D, et al.
…2012. The Brighton Collaboration Benefit-Risk Assessment of VAccines by TechnolOgy (BRAVATO) was formed to evaluate the safety and other key features of new platform technology vaccines. This manuscript reviews key features of the ChAdOx1-vectored vaccines. The simian adenovirus …
Hoft SG, Kauffman KD, Sakai S, Lindestam Arlehamn CS, Sette A, et al.
…nding T cells may enhance the airway immunogenicity of oral vaccines.
Socha A, Klein J
Background Migrant populations in the European Union (EU) suffer a disproportionate burden of infectious diseases and may be particularly vulnerable due to poor conditions in countries of origin or throughout transit to the host country. Given the rising level of migration into E…
Ostermann J, Vasudevan L, Baumgartner JN, Ngadaya E, Mfinanga SG
Background Vaccination is a cost-effective strategy for reducing morbidity and mortality among children under 5 years old. To be fully protected from diseases such as tuberculosis, diphtheria, pertussis, and polio, children must receive all recommended vaccinations in a timely ma…
Bhattacharyya A, Shahabuddin SM
…asles vaccine for children and rubella and adult diphtheria vaccines for pregnant women. We conducted this rapid review on adult immunization relevant for India, as recent COVID-19 experience revealed how newly emergent or re-emergent pathogens could have their onslaughts on the …
Zhuang L, Ye Z, Li L, Yang L, Gong W
…cy, particularly in adults. Efforts to develop effective TB vaccines have been ongoing for nearly a century. In this review, we have examined the current obstacles in TB vaccine research and emphasized the significance of understanding the interaction mechanism between MTB and ho…
Rupali Limaye, Jessica Schue, Berhaun Fesshaye, Prachi Singh, Emily Miller, et al.
… to maternal and neonatal health. For TB and GBS, there are vaccines in various stages of clinical trial development, and malaria and RSV vaccines are available. This study aimed to examine pregnant women's attitudes toward TB, malaria, GBS, and RSV vaccines in Brazil, Ghana, Ken…
Shuihua Lu
There are four populations in Recombinant Mycobacterium tuberculosis Vaccine Freeze-dried (AEC/BC02) phase I clinical research. The clinical study adopt open research design. Population I have 25 subjects who received Tuberculin purified protein derivative(TB-PPD) skin test and …
И В Фельдблюм, M. Yu. Devyatkov, M. Kh. Alyeva
Relevance Hepatitis B and tuberculosis are a serious global health problem. Babies under one are at high risk of a severe form of these diseases and mortality. Immunization of newborns plays a key role both in the individual prevention of hepatitis B and tuberculosis and in reduc…
И В Фельдблюм, M. Yu. Devyatkov, M. Kh. Alyeva
Relevance Hepatitis B and tuberculosis are a serious global health problem. Babies under one are at high risk of a severe form of these diseases and mortality. Immunization of newborns plays a key role both in the individual prevention of hepatitis B and tuberculosis and in reduc…
Tingting Li, K. J. Zhu, Yujie Kuang, Hongbo Qu, Zhang Qi, et al.
Abstract Background: Tuberculin skin test (TST) has been the most commonly used test for diagnosis of tuberculosis (TB) infection in China for many years, because of well-established algorithms for test interpretation and a good cost-effectiveness. To our knowledge , there is no …
Thakur A, Ingvarsson PT, Schmidt ST, Rose F, Andersen P, et al.
Liquid vaccine dosage forms have limited stability and require refrigeration during their manufacture, distribution and storage. In contrast, solid vaccine dosage forms, produced by for example spray drying, offer improved storage stability and reduced dependence on cold-chain fa…
Tong Yu, ChenChao Zhang, Jun-Hong Xing, Tong Zhang, Zhiqiang Xu, et al.
…, the urgent development of innovative and efficacious mRNA vaccines is imperative. In our study, we synthesized six unique mRNA vaccine formulations: the Receptor Binding Domain (RBD) monomer vaccine, RBD dimer (2RBD) vaccine, RBD-Ferritin (RBD-Fe) vaccine, ubiquitin-modified wi…