Showing 176–200 of 200 documents
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Helen McShane
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines induce both CD4+ and CD8+ T cells and thus offer a potential new approach to a TB vaccine. DNA vaccines encoding various antigens from M. tuberculosis have been evaluated in the murine model, and t…
Agopian A, Young H, Quinlan S, Rice MM
…ases not only requires high coverage but also requires that vaccines are administered in a timely manner. Prior studies have examined the timing of vaccinations in Armenia and found that although vaccination coverage is high, children are not receiving the vaccinations in a timel…
Rhonita Schutz
Tuberculosis (TB) has many known risk factors that contribute to its persistence worldwide, particularly in developing countries. Aotearoa New Zealand (NZ), as a high-income country, is fortunate to fall in the low-risk category. However, the incidence of TB is more common in par…
Eskild Petersen, David S.C. Hui, Jean B. Nachega, Francine Ntoumi, Delia Goletti, et al.
… for increasing access to affordable drugs, diagnostics and vaccines for other epidemic diseases affecting resource-poor countries. In April, 2021, a Brazil judge suspended drug patent extensions, a preliminary decision that could lower costs for drugs critical to treating COVID-…
Ullah I, Bibi S, Ul Haq I, Safia, Ullah K, et al.
…unogenicity and safety of the M72/AS01 E and MVA85A subunit vaccines. The M72/AS01 E is a novel peptide-based vaccine currently in progress, which may increase the protection level against TB infection. The MVA85A was a viral vector-based TB subunit vaccine being used in the clin…
Gurudeeban Selvaraj, Satyavani Kaliamurthi, Dongqing Wei
…hus providing a promising foundation for next-generation TB vaccines (1). This work also exemplifies how integrating pathogen genomics with host response profiling can accelerate rational vaccine design.Building on the theme of precision, the second study focuses on cervical canc…
José Victor Bortolotto Bampi, Ghislaine Gonçalez de Araujo Arcanjo, Karina Marques Santos, Michele Souza Ventura, Everton Ferreira Lemos, et al.
…obal threat, with unequal burden across populations. New TB vaccines are in development, and people deprived of liberty (PDL) represent a vulnerable group that may benefit from vaccination. This study evaluated acceptability of a hypothetical new TB vaccine and factors associated…
Sharma A, Kerkhoff AD, Haambokoma M, Shamoya B, Sikombe K, et al.
…ves To estimate intention to receive newly introduced adult vaccines among community members and healthcare workers (HCWs) in Lusaka, Zambia in the context of previous COVID-19 vaccine uptake and perceived disease threat and, identify trusted sources of vaccine information. Metho…
N.А. Matsegora, A.V. Kaprosh
…uding the AEC/BC02, Ad5 Ag85A and ChAdOx185A-MVA85A phase 1 vaccines, MTBVAC, ID93+GLA-SE, TB / FLU-04L and the GamB phase vaccine. 2a, amplifiers DAR-901, H56:IC31, M72/AS01, BCG revaccination and RUTI vaccine in phase 2b, VPM1002 and MIP/Immuvac in phase 3. Candidate TB vaccine…
Palmer MV, Hwang S, Kanipe C, Putz EJ, Fernandes LGV, et al.
…ablished technique used for stabilizing bioproducts such as vaccines. Methods In the current study, cattle were vaccinated in two phases. In each phase, cattle were divided into three groups. Group 1 received BCG injected SQ, Group 2 received liquid BCG delivered to the posterior…
Eleni I. Katsarou, George C. Fthenakis
…inst staphylococcal mastitis’ and ‘total number of optional vaccines administered’. Univariable and multivariable analyses were first performed to establish associations of each of the above outcomes with climatic variables. Then, the same approach was employed to assess the impo…
Sasheela Ponnampalavanar, Anjanna Kukreja, Sazali Basri, Sheron Sir Loon Goh, Syifa’ Ahmad Faisol, et al.
Background and objectives: Since the introduction of the COVID-19 vaccine through the National COVID-19 Immunization Program in Malaysia in February 2021, the number of cases of severe COVID-19 and mortality have progressively decreased. We explored the association between vaccin…
Veronika A. Petrova, Leyla S. Namazova-Baranova, Мarina V. Fedoseenko, Dina S. Rusinova
…). It has also been shown that timely vaccination with both vaccines in the early neonatal period significantly reduces the risk of AD in general infant population compared to non-vaccinated individuals or those who had only one vaccine (odds ratio [OR] 0.374; 95% confidence inte…
Badurdeen S, Marshall A, Daish H, Hatherill M, Berkley JA
Importance Bacillus Calmette-Guérin (BCG) vaccination is commonly delayed in infants who are preterm and have low birth weights (LBW) despite the association of early vaccination with better vaccination coverage and potentially nonspecific benefits for survival. Objective To dete…
Akhil Sharma, Shaweta Sharma, Mobeen Shaik, Hrithik Dey, Pankaj Agrawal
…including influenza, COVID-19, or tuberculosis, traditional vaccines such as oral formulations and injections have limitations in effectively targeting these pathogens. However, the solution to this challenge lies in the development of inhalable vaccines. Inhalable vaccines take …
Puck T. Pelzer, Marit Holleman, Michelle E. H. Helinski, Ana Lúcia Weinberg, Pauline Beattie, et al.
…t populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial…
Pelzer PT, Holleman M, Helinski MEH, Weinberg AL, Buis J, et al.
…t populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial…
Ting Huang, Master
…esign. In this trial, 160 subjects were enrolled. The test vaccines are divided into four dose groups: dose group 1 (0.025mg / 0.1ml / person), dose group 2 (0.05mg / 0.1ml / person), dose group 3 (0.075mg / 0.1ml / person), dose group 4 (0.1mg / 0.1ml / person), each Each dose …
Xie Y, Tian X, Zhang X, Yao H, Wu N
Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and polio is almost extinct because of vaccines…
Mark Hatherill, MD, FCPaed
…as been excluded. Clinical trials of new viral-vectored TB vaccines, including MVA85A, a modified vaccinia virus Ankara (MVA) vaccine expressing the Mycobacterium tuberculosis antigen 85A, have to date enrolled infants who were already vaccinated with routine BCG at birth. Howev…
Jia Q, Masleša-Galić S, Nava S, Horwitz MA
… attenuated L. monocytogenes multiantigenic M. tuberculosis vaccines, especially the rLm5Ag(30) vaccine expressing a fusion protein of 23.5/Mpt64, TB10.4/EsxH, ESAT6/EsxA, CFP10/EsxB, and r30, enhances BCG-induced protective immunity against M. tuberculosis aerosol challenge. In …
Peng S, Ferrall L, Gaillard S, Wang C, Chi WY, et al.
Immunotherapy for cervical cancer should target high-risk human papillomavirus types 16 and 18, which cause 50% and 20% of cervical cancers, respectively. Here, we describe the construction and characterization of the pBI-11 DNA vaccine via the addition of codon-optimized human p…
GBD 2023 Vaccine Coverage Collaborators
…ne coverage; (2) we forecast coverage of select life-course vaccines up to 2030; and (3) we analyse progress needed to reduce the number of zero-dose children by half between 2023 and 2030. **FINDINGS:** Overall, global coverage for the original EPI vaccines against diphtheria, …
Renee Gresh, Kimberly Davidow, Jeff Myers, D Morley
Abstract Introduction: It is well known that children with cancer are at an increased risk of severe influenza infections due to immunosuppression and co-morbidities. Serious influenza infections can lead to increased hospitalizations, outpatient visits, and delays in treatment. …
Fabiola Silva-Angulo, Henao-Tamayo, Marcela, Weir, Tiffany, Abdo, Zaid, Izzo, Angelo
Tuberculosis is an infectious lung disease responsible for approximately 1.4 million human deaths, world-wide every year. The causal agent of tuberculosis, Mycobacterium tuberculosis (M. tuberculosis), has been estimated to latently infect one-third of the human population. Curre…