Showing 176–200 of 200 documents
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Guo Y, Yang J, Wang W, Wu X, Wan B, et al.
Background New antituberculosis drugs have recently been approved for the treatment of multidrug-resistant tuberculosis TB (MDR-TB). We aimed to describe the distributions of bedaquiline, delamanid, linezolid, clofazimine, and capreomycin MIC values for M. tuberculosis . Methods …
Bhanushali A, Atre S, Nair P, Thandaseery GA, Shah S, et al.
Treatment decisions for tuberculosis (TB) in the absence of full drug-susceptibility data can result in amplifying resistance and may compromise treatment outcomes. Genomics of Mycobacterium tuberculosis ( M.tb ) from clinical samples enables detection of drug resistance to multi…
Morey-León G, Mejía-Ponce PM, Granda Pardo JC, Muñoz-Mawyin K, Fernández-Cadena JC, et al.
Introduction Tuberculosis (TB) is among the deadliest diseases worldwide, and its impact is mainly due to the continuous emergence of resistant isolates during treatment due to the laborious process of resistance diagnosis, nonadherence to treatment and circulation of previously …
Bhering M, Kritski A
This study aimed to reinforce the importance of the epidemiological surveillance of multidrug-resistant tuberculosis (MDR-TB) in Rio de Janeiro State (RJ). Here, we reviewed seven articles we published between 2018 and 2022. This study had two phases. The quantitative phase where…
Badoum G, Ouédraogo AR, Fiogbé AA, Kuate Kuate A, Soumana A, et al.
Drug-resistant tuberculosis (DR-TB) poses a significant public health challenge, particularly in resource-limited settings. The prevalence and management of DR-TB in African countries require comprehensive strategies to improve patient outcomes and control the spread of the disea…
Chin KL, Anibarro L, Chang ZY, Palasuberniam P, Mustapha ZA, et al.
Tuberculosis (TB) is the world's second-deadliest infectious disease. Despite the availability of drugs to cure TB, control of TB is hampered by the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). The presence of MDR/XD…
Gain A, Jain AK, Bhalla M, Aggarwal AN, Dhammi IK, et al.
Background The present study was undertaken to determine the incidence of drug resistance against anti-tubercular drugs among patients from an endemic zone. Methodology: Forty consecutive clinico-radiologically diagnosed patients of osteoarticular tuberculosis (29: spine, 11: ext…
Günther G, Guglielmetti L, Leu C, Lange C, van Leth F
Objectives To evaluate the access to comprehensive diagnostics and novel antituberculosis medicines in European countries. Methods We investigated the access to genotypic and phenotypic Mycobacterium tuberculosis drug susceptibility testing and the availability of antituberculosi…
Raikar SR, G S, Sneha S, Rajkumar J
Tuberculosis (TB) is a highly infectious disease and a global health challenge caused by Mycobacterium tuberculosis . The disease presents as drug-sensitive TB or drug-resistant TB (DR-TB). DR-TB could be of various types like isoniazid mono-resistant, multidrug-resistant (MDR)-r…
Shah I, Bhamre R, Shetty NS
Background Diagnosing extrapulmonary tuberculosis (EPTB) can be challenging because of a variety of presentations. We assessed the accuracy of the Xpert MTB/RIF assay in diagnosing EPTB in children. Methods Of the 255 children diagnosed to have tuberculosis (TB) who underwent tes…
Lin M, Chen YW, Li YR, Long LJ, Qi LY, et al.
Background Line probe assays (LPAs) are PCR-based assays used for the rapid diagnosis of Mycobacterium tuberculosis (MTB) and drug-resistant tuberculosis (DR-TB). But studies on its performance are insufficient. Thus, in this study, we conducted a systematic review and meta-analy…
Shiromwar SS, Khan AH, Chidrawar V
Objective Extensively drug-resistant tuberculosis (XDR-TB) has raised a great threat to human health globally, especially in developing countries. The objective of the present study is to collate and contrast the proportions of treatment outcome in the previously published XDR-TB…
Thu NQ, Tien NTN, Yen NTH, Duong TH, Long NP, et al.
…ugs, aiding in the discovery of potential biomarkers for TB diagnostics, treatment monitoring, and outcome evaluation. This article highlighted the current progresses in TDM of anti-TB drugs based on LC-MS bioassay in the last two decades. Besides, we discussed the advantages and…
Hasan MZ, Ahmed S, Islam Z, Dorin F, Rabbani MG, et al.
Background Bangladesh National Tuberculosis (TB) Control Programme (NTP) has deployed improved diagnostic technologies which may drive up the programme costs. We aimed to estimate the supply-side costs associated with the delivery of the NTP and the funding gap between the cost o…
Claassens M, Dreyer V, Nepolo E, Mokomele Q, van Rooyen G, et al.
…ed for the implementation of interventions that allow rapid diagnostics to break MDR TB transmission chains in the country. A borderline RIFr mutation in the dominant outbreak strain causing discrepancies between phenotypic and genotypic resistance testing results may require bre…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
…n, which could be an important way for vaccine development, diagnostics, and novel host-directed therapeutic strategies. The recent development of new drugs and combinational therapies for drug-resistant tuberculosis through major collaboration between industry, donors, and acade…
Dohál M, Dvořáková V, Šperková M, Porvazník I, Cabibbe AM, et al.
…sequencing (WGS) is an increasingly preferred method in the diagnostics and monitoring of the transmission dynamics of resistant forms of tuberculosis (TB). The aim of the study was to, for the first time, use the sequencing-based analysis to study the transmission and resistance…
Micheni LN, Kassaza K, Kinyi H, Ntulume I, Bazira J
Multidrug-resistant tuberculosis (MDR-TB) has become a major threat to the control of tuberculosis globally. Uganda is among the countries with a relatively high prevalence of tuberculosis despite significant control efforts. In this study, the drug resistance of Mycobacterium tu…
Islam MM, Alam MS, Liu Z, Khatun MS, Yusuf B, et al.
Clofazimine (CFZ) and bedaquiline (BDQ) are currently used for the treatment of multidrug-resistant (MDR) Mycobacterium tuberculosis ( Mtb ) strains. In recent years, adding CFZ and BDQ to tuberculosis (TB) drug regimens against MDR Mtb strains has significantly improved treatmen…
Hameed HMA, Fang C, Liu Z, Ju Y, Han X, et al.
Objective Rifampicin (RIF)-resistance, a surrogate marker for multidrug-resistant tuberculosis (TB), is mediated by mutations in the rpoB gene. We aimed to investigate the prevalence of mutations pattern in the entire rpoB gene of Mycobacterium tuberculosis clinical isolates and …
Ahrenstorf G, Dopfer-Jablonka A, Joean O, Knuth C, Silchmueller M, et al.
Purpose To describe the clinical characteristics of refugees with HIV from Ukraine that seek continuation of medical care in Germany. Methods Fourty-six refugees with HIV that had left Ukraine between 24 February and 30 December 2022 were examined. Information on patients' histor…
Cohen KA, Stott KE, Munsamy V, Manson AL, Earl AM, et al.
… critical concentration methods and the design of molecular diagnostics need to be revisited to provide more accurate assessments of streptomycin resistance for gidB -containing isolates. For patients harboring isolates of M. tuberculosis with high-level amikacin resistance confe…
Fellous S, Rkain H, Tahiri L, Bouraqadi A, Nassar I, et al.
Pre-extensively drug resistant tuberculosis (pre-XDR-TB) has been an area of growing concern, and posing a threat to global efforts of TB control. We report a case of PreXDR-TB spondylodiscitis with resistance to a Fluoroquinolone, in an immunocompetent patient under antibacillar…
Mvelase NR, Balakrishna Y, Lutchminarain K, Mlisana K
Objectives South Africa ranks among the highest drug-resistant tuberculosis (DR-TB) burdened countries in the world. This study assessed the changes in resistance levels in culture confirmed Mycobacterium tuberculosis (MTB) in the highest burdened province of South Africa during …
Paleckyte A, Dissanayake O, Mpagama S, Lipman MC, McHugh TD
Globally, tuberculosis (TB) is a leading cause of death from a single infectious agent. Healthcare workers (HCWs) are at increased risk of hospital-acquired TB infection due to persistent exposure to Mycobacterium tuberculosis (Mtb) in healthcare settings. The World Health Organi…