Showing 176–200 of 200 documents
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Juexin Wang, Xiaoling Lai, Chuchu Wu, Jielian Wang, Yong Liao, et al.
Accurate detection of drug-resistant Mycobacterium tuberculosis (MTB) is essential for tuberculosis control, particularly with increasing multidrug-resistant strains. Whole-genome sequencing (WGS), as a supplement to phenotypic drug susceptibility testing (DST), holds great poten…
Adhi Kristianto Sugianli, Ida Parwati
Gram-Negative Bacteria (GNB) have been widely reported to cause worldwide infections and life-threatening. The high prevalence of drug-resistant GNB causes the treatment of GNB to become difficult. This case report describes a stepwise laboratory approach and interpretation for G…
Eather G, Wilson M, Goffinet C, Ryan E
Guideline-based recommendations for diagnosis of latent TB in highly immune suppressed populations are difficult to interpret and poorly characterised. More accurate biomarkers independent of T-cell functions are urgently required. https://bit.ly/41P8vTa.
Li X, Deng Y, Wang J, Jing H, Shu W, et al.
Background In this study, we aimed to describe the impact of the Genotype® MTBDRplus line probe assay (LPA) for multidrug-resistant tuberculosis (MDR-TB) on total costs in a high-burden setting in China. The second objective was to evaluate the performance of HAIN on smear-positi…
Yaser Jasem1 , Al-khatony2 , Halah Abdulkhaliq Awadh Alhadethy3 , Mahmood Abduljabar Altobjy4
Background and Objective: Pulmonary tuberculosis(PTB) is a serious disease that mainly affects thelungs. The aim of this study was a Comparison between conventional, and molecular methods to diagnoseM.tuberculosis complex (MTBC) and using serum TNF-? levels as a biomarker for eva…
Rashmi Ratnam, Parul Jain, Faisal Abbas, Bhoopendra Pandey, Manu Singh, et al.
**INTRODUCTION:** Fluoroquinolones (FQs) are key components of World Health Organization (WHO)-recommended regimens for multidrug-resistant tuberculosis (MDR-TB). Accurate detection of FQ resistance is essential for optimizing treatment. This study evaluated the concordance betwe…
Kessel J, Göymen E, Wolf T, Wetzstein N, Küpper-Tetzel C, et al.
Objectives Patients with open pulmonary tuberculosis (opTB) are subject to strict isolation rules. Sputum smear microscopy is used to determine infectivity, but sensitivity is lower than for culture. This study aimed to investigate the clinical relevance of this mismatch in conte…
Qadir M, Faryal R, Khan MT, Khan SA, Zhang S, et al.
Importance An accurate diagnosis of drug resistance in clinical isolates is an important step for better treatment outcomes. The current study observed a higher discordance rate of rifampicin resistance on Mycobacteria Growth Indicator Tube (MGIT) drug susceptibility testing (DST…
Sun Q, Wang S, Dong W, Jiang G, Huo F, et al.
Objectives The diagnosis of osteoarticular tuberculosis (TB) remains challenging and results in under- or over-diagnosis. The aim of the present study was to evaluate performance of the novel next-generation Xpert MTB/RIF Ultra (Xpert Ultra) in comparison to culture and Xpert MTB…
Karunaratne RE, Wijenayaka LA, Wijesundera SS, De Silva KMN, Adikaram CP, et al.
Background The increased transmission of multidrug-resistant (MDR) tuberculosis (TB) poses a challenge to tuberculosis prevention and control in Sri Lanka. Isoniazid (INH) is a key element of the first line anti tuberculosis treatment regimen. Resistance to INH may lead to develo…
Laura Madukaji, Francis Enenche Ejeh, Eke Ofuche, Jay Samuel, Femi Owolagba, et al.
Background and study aim: The use of LPA is still new in Nigeria and only available in TB reference laboratories. In this study, the performance of LPA version 2.0 was evaluated for the detection of resistant to first-line anti-TB drugs. Patients and Methods: We evaluated t…
Smita Mohod, Swati Bhise, Prasanna Raut, Bhoomika Choudhary
Introduction: In underdeveloped countries, Tuberculosis (TB) is a major source of morbidity & mortality. For clinical microbiologists, identifying and detecting Mycobacterium tuberculosis (MTB) constitutes as an important hurdle. Thus, to eliminate the disease early and lower…
M.І. Sakhelashvili, O Kostyk, O.I. Sakhelashvili–Bil, Z.I. Pіskur
Among 256 patients examined, 145 were diagnosed with multidrug-resistant pulmonary TB: 67 children and 78 teenagers from the focies with the multidrug-resistant TB (the main group), and 111 patients (35 children and 76 teenagers) from the focies with a chemosensitive TB (the cont…
Erick Auma, Rencia Alberts, Brigitta Derendinger, Rouxjeane Venter, Elizabeth M Streicher, et al.
**BACKGROUND:** Drug susceptibility testing (DST) is essential for starting people on effective tuberculosis (TB) regimens. No published data exist for the high-throughput LiquidArray MTB-XDR (LA-XDR) test, which detects Mycobacterium tuberculosis complex (MTBC) and fluoroquinolo…
Bisimwa BC, Nachega JB, Warren RM, Theron G, Metcalfe JZ, et al.
Background Rifampicin (RIF) resistance is highly correlated with isoniazid (INH) resistance and used as proxy for multidrug-resistant tuberculosis (MDR-TB). Using MTBDRplus as a comparator, we evaluated the predictive value of Xpert MTB/RIF (Xpert)-detected RIF resistance for MDR…
Bruno Luukinen
<i>Mycobacterium tuberculosis</i> -bakteeri (Mtb) aiheuttaa tuberkuloosia (TB), joka on eräs globaalisti merkittävimmistä infektiotaudeista. Siinä missä tuberkuloosin esiintyvyys on laskenut tasaisesti, ei-tuberkuloottisten eli ympäristömykobakteerien (<i>nontuberculous mycobacte…
Wollenberg K, Harris M, Gabrielian A, Ciobanu N, Chesov D, et al.
Background Recurrence of drug-resistant tuberculosis (DR-TB) after treatment occurs through relapse of the initial infection or reinfection by a new drug-resistant strain. Outbreaks of DR-TB in high burden regions present unique challenges in determining recurrence status for eff…
HossamM Abdel Hamid, MohamedA Tag Eldin, M.Masoud Elnady
Background Over the past decade, genotyping of Tuberculosis strains has become an increasingly valuable tool in tuberculosis (TB) control. Molecular epidemiology has helped to identify unsuspected transmission, determine likely locations of transmission, and measure the extent of…
Dornelas Moreira J, Rodrigues Silva H, de Paulo Coelho Peixoto de Toledo V, Mara Pinto Dabés Guimarães T
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, usually chronic and has a progressive clinical course. Despite the availability of effective chemotherapy, TB is a leading killer of young adults worldwide and the global multi-drug resistant TB is r…
Sheen P, Rodriguez J, Alcántara R, Vargas J, Grandjean L, et al.
Most culture-based methods for tuberculosis diagnosis remain low-cost options for low- and mid-income countries. The MODS culture is a rapid and low-cost assay to diagnose tuberculosis and determine drug susceptibility. However, its implementation is limited due to the low access…
Zumla A, Abubakar I
By the end of 2017, an estimated 68.5 million people were displaced from their homes worldwide, of whom 25.4 million were refugees. The transmission and globalization of multi-drug resistant tuberculosis during refugee migration is a now priority issue in the public health agenda…
Shera Tan, Bernard Yu‐Hor Thong
When the tubercle bacilli were first discovered in 1882 by Dr Robert Koch, tuberculosis (TB) killed one in every four persons in England.1 At that time, there had been no known cure for TB disease, apart from high altitude, fresh air and good nutrition in hundreds of sanatoria bu…
Platon Eliseev, Anne Detjen, Russell Dacombe, Patrick Phillips, S. Bertel Squire, et al.
The use of molecular genetic tests as a part of tuberculosis patients examination made it possible to reduce the time for TB diagnosis and determination of drug resistance (DR) of M. tuberculosis (MTB) in Arkhangelsk Region. Early detection of multiple drug resistant tuberculosis…
Sakhelashvili M, Kostyk O, Sakhelashvili-Bil O, Piskur Z
Among 256 patients examined, 145 were diagnosed with multidrug-resistant pulmonary TB: 67 children and 78 teenagers from the focies with the multidrug-resistant TB (the main group), and 111 patients (35 children and 76 teenagers) from the focies with a chemosensitive TB (the cont…
Moga S, Bobosha K, Fikadu D, Zerihun B, Diriba G, et al.
Background Isoniazid (INH) resistant Mycobacterium tuberculosis (Hr-TB) is the most common type of drug resistant TB, and is defined as M tuberculosis complex (MTBC) strains resistant to INH but susceptible to rifampicin (RIF). Resistance to INH precedes RIF resistance in almost …