Showing 176–200 of 200 documents
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Yoshihiro Kobashi, Toru Oga
Background: The aim of this study was to evaluate the usefulness of two interferon-gamma release assays (IGRAs) (QuantiFERON-TB Plus (QFT-plus) and T-SPOT.TB assay) for patients suspected of having tuberculosis (TB) infection as supportive methods for diagnosing TB. Patients and …
Lu P, Xu J, Wang R, Gong X, Liu Q, et al.
Background The ESAT6-CFP10 (EC) skin test is recommended by the World Health Organization for latent tuberculosis infection (LTBI). However, it is still unknown how the EC skin test performs in students during a school tuberculosis outbreak. Methods We conducted an epidemiologica…
María Victoria Pinedo, Martín Giorgi, María A Bajo, Borja Quiroga
Tuberculosis (TB) is a significant clinical and public health problem for patients with chronic kidney disease (CKD), particularly those requiring hemodialysis (HD). This population is particularly vulnerable due to the profound alteration of the immune response characteristic of…
Manish Sharma
HIV/TB co-infection presents a significant public health challenge due to the synergistic interaction between the twopathogens. HIV weakens the immune system, making individuals more susceptible to TB infection and reactivationof latent TB. Conversely, active TB accelerates the p…
Villar-Hernández R, Blauenfeldt T, García-García E, Muriel-Moreno B, De Souza-Galvão ML, et al.
Interferon (IFN)-γ release assays (IGRAs) are used to diagnose latent tuberculosis (TB) infection (LTBI). To improve the accuracy of these tests, different approaches, such as alternative cytokine detection and using different antigens, are considered. Following this purpose, thi…
Lee JY, Kim BJ, Koo HK, Kim J, Kim JM, et al.
Tuberculosis remains a major public health problem. Conventional tests are inadequate to distinguish between active tuberculosis (ATB) and latent tuberculosis infection (LTBI). We measured antibody responses to Mycobacterium tuberculosis antigens ( Mycobacterium tuberculosis chor…
Biswajit Chakraborty, Amaj Laskar, Anamika Baruah, Remesh Kumar, Mustafa A. Barbhuiya
Tuberculosis (TB) poses a significant public health challenge in India. According to the World Health Organization (WHO), India tops the list of 30 countries responsible for 87% of global TB cases in 2023. Recent data indicates that India's TB incidence rate was 195 cases per 100…
Xu W, Yang J, Yu H, Li S
Objectives To determine the usefulness of LINC00152 and LARS2-AS1 as potential biomarkers for latent tuberculosis (LTB) and active tuberculosis (ATB), as well as their effect on Mycobacterium (Mtb) infection. Methods The expression levels of LINC00152 and LARS2-AS1 in the health,…
Balcells ME, Ruiz-Tagle C, Tiznado C, García P, Naves R
Background A simple blood test for detecting active tuberculosis (TB) could be key to this epidemic containment, given that a large proportion of patients are unable to produce sputum for testing. Currently available interferon-γ release assays (IGRAs) are inadequate to diagnose …
Hassan B, Alshehabi Z
Introduction Breast cancer affects one in eight women during their lifetime; it may coincide with other diseases due to its high prevalence. Different pathologies that occur simultaneously with breast cancer, or later during its course, lead to multiple interactions with cancer a…
Yu Rim Lee, Heechul Park, Yun-Jeong Kang, Sung‐Bae Park, J. Kim, et al.
Objectives: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis (MTB) bacteria.According to a World Health Organization report, a third of the world' s population has latent TB infection (LTBI), and 5%-10% of people with LTBI are at risk of developing …
Shoji Hashimoto, Hong Zhao, Michiyo Hayakawa, Koichi Nakajima, Y‐h. Taguchi, et al.
Abstract Background Mycobacterium tuberculosis is known to cause latent tuberculosis infection (LTBI) in 25–50% of the cases, of whom 10–20% develop active tuberculosis (TB). Notably, no marker currently exists for judging the therapeutic effect of TB; it is currently judged by c…
Juste RA, Fernández-Veiga L, Fuertes M, Fernández-Ortiz de Murua I, Cardona G, et al.
Tuberculosis (TB) is a disease caused by members of the M. tuberculosis complex (MTC) that affects numerous species. M. caprae, a member of the complex which is close to M. bovis, is emerging and affects several different hosts that include goats, cattle, sheep, pigs, rabbits, wi…
Zhang L, Yang Z, Bao X, Ma H, Ge Q, et al.
Objective This study aimed to compare the accuracy of QuantiFERON-TB Gold Plus (QFT-Plus) and T-SPOT.TB for diagnosing active tuberculosis (ATB) in febrile patients, to explore influencing factors of positive results and to verify the potential value of QFT-Plus in the identifica…
Ceylan AN, Canat HD, Komec S, Gulmez A
Background Tuberculosis is still a significant global health challenge, with latent tuberculosis infection (LTBI) posing a risk for the development of active disease. This study aimed to compare the performance of the STAN-DARD F TB-Feron FIA test with the QuantiFERON-TB Gold Plu…
Grant Theron, PhD, Balthazar Nyombi, PhD, Kidist Bobosha, PhD, Carol Holm-Hansen, PhD
…el and expedite referral to facilities supporting molecular diagnostics. An ideal cost-effective triage test should be as sensitive as Xpert and cost less than US $5 to reduce total diagnostic costs by 30-40%, potentially saving national TB programmes US $36 million/year. The ex…
Anna Okunola, PhD
…n often not produce high quality sputum (which most current diagnostics rely on). Several blood transcriptional diagnostic signatures produced due to immune responses to M. tuberculosis infection have previously been described, however there is lack of real-world performance data…
Keertan Dheda, MBChB, PhD
…environments. However, the poor performance of conventional diagnostics makes the strategy costly and unpalatable for policy makers. If it can be shown that a package of new diagnostic technologies significantly enhances ease and speed of diagnosis, and time to treatment initiati…
Alimuddin Zumla, Jeremiah Chakaya, Mishal Khan, Razia Fatima, Christian Wejse, et al.
…ances that have the potential to change the landscape of TB diagnostics and management, such as culture-free sequencing and surveillance of antimicrobial resistance to guide precision medicine approaches, as well as some of the challenges involved. Whole genome sequencing-based d…
Pierre Goussard, Gerhard Walzl
The world is in the grip of a COVID-19 pandemic but tuberculosis (TB) remains responsible for the greatest number of deaths from a single infectious disease worldwide. Of the 10 million new cases of active TB each year, approximately 10% occur in children younger than 15 years of…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
…ated guidelines on tuberculosis: module 3: diagnosis: rapid diagnostics for tuberculosis detection, 2021 update 2021, https://www.who.int/publications-detail-redirect/9789240029415; 2021 [accessed 27 February 2024].Google Scholar, 5World Health Organization. WHO consolidated guid…
Leyla Larsson, Claire J Calderwood, Rishi K Gupta, Celso Khosa, Katharina Kranzer
…s goes beyond mere semantics. The absence of state-specific diagnostics and therapeutics stems from the lack of definitions and reference standards, indicating that the current tuberculosis spectrum model is not useful in clinical or programmatic settings. Hence, the establishmen…
Kadi C, Ahmadi N, Houdou A, Badisy IE, Bouaddi O, et al.
Background Latent TB infection (LTBI) affects one fourth of the global population. Currently, there is an absence of an optimal strategy for distinguishing between active tuberculosis (aTB) and LTBI. While some researchers have explored cytokines other than interferon-gamma (IFN-…
Warsinske H, Vashisht R, Khatri P
…Health Organization (WHO) and Foundation for Innovative New Diagnostics (FIND) have published target product profiles (TPPs) calling for non-sputum-based diagnostic tests for the diagnosis of active tuberculosis (ATB) disease and for predicting the progression from latent tubercu…
Wei Z, Li Y, Wei C, Li Y, Xu H, et al.
Background One forth whole-world population is infected with Mycobacterium tuberculosis (Mtb), but 90% of them are asymptotic latent infection without any symptoms but positive result in IFN-γ release assay. There is lack of ideal strategy to distinguish active tuberculosis (TB) …