Showing 176–200 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Tadesse M, Abebe G, Bekele A, Bezabih M, Yilma D, et al.
Objectives The diagnosis of extrapulmonary tuberculosis (EPTB) is often made on clinical suspicion alone, resulting in both under- and overdiagnosis and relatively poor outcomes. In this study, we evaluated the clinical utility of the Xpert MTB/RIF on routinely collected extrapul…
Mikashmi Kohli
BackgroundThe WHO estimates that globally in 2021, 10.6 million people fell ill with tuberculosis (TB). Nearly 4.2 million people were either not diagnosed or not reported during 2021, and this makes TB diagnosis the biggest challenge. With the emergence of molecular rapid tests …
Rajesh Kumar Yadav, Durgesh Kumar, Yogendra Singh Yadav, Dinesh Kumar Singh, Amit Singh, et al.
Introduction: Tuberculosis (TB) remains one of the deadliest communicable diseases worldwide. The introduction of early and rapid diagnostic test such as Cartridge Based Nucleic Acid Amplification Test (CBNAAT) creates opportunities for improvement in early and fast detection of …
Ashish Kumar Gupta, Prashant Yadav, Somnath Bhattacharya, Aditya Kumar Gautam, Adesh Kumar
Background: Extrapulmonary tuberculosis poses a great challenge in the diagnosis and management due to the paucibacillary nature of the disease and limited tests available for early diagnosis. Tuberculous lymphadenopathy is the most common extrapulmonary manifestation of tubercul…
Allahyartorkaman M, Mirsaeidi M, Hamzehloo G, Amini S, Zakiloo M, et al.
Diagnostic accuracy of Xpert MTB/RIF assay for pulmonary tuberculosis (PTB) and extrapulmonary TB (EPTB) has not been investigated in Iran. This study was aimed to assess the diagnostic accuracy of Xpert MTB/RIF assay for both PTB and EPTB. A total of 2111 clinical samples (1218 …
Shao L, Qiu C, Zheng L, Yang Y, Yang X, et al.
Design A prospective multicentre study was conducted to compare the diagnostic accuracy of the GeneXpert MTB/RIF Ultra (Xpert Ultra) and cell-free DNA (cfDNA) assay for tuberculous meningitis (TBM) in China. Methods A prospective cohort study was conducted among individuals with …
Yousef Ahmed, Amany Omar, Abd-ElazimAbo Elfadl, Moustafa Hosny
Background There is no doubt about the diagnostic role of the GenXpert test in pulmonary tuberculosis (TB). Nevertheless, few data are available with regard to the use of this assay to test nonsputum clinical samples when investigating suspected extrapulmonary TB such as pleural …
Promsena P, Jantarabenjakul W, Suntarattiwong P, Sudjaritruk T, Anugulruengkitt S, et al.
Background Diagnosing tuberculosis (TB) in children is challenging due to its paucibacillary nature. Loop-mediated isothermal amplification (TB-LAMP) is a simple, rapid, and specific point-of-care molecular diagnostic test. However, evaluation of its performance remains limited i…
Cherisha Selvaraj, O Johnson, C Kailash, Iqbal Nayyar
Although tuberculosis is commonly identified as a respiratory disease, its extrapulmonary manifestations, particularly in the Central Nervous System (CNS), pose significant diagnostic and treatment challenges. This report discusses a 73-year-old woman who presented with a month-l…
Mao‐Shui Wang, Junli Wang, Xinjie Liu, Yanan Zhang
Background To establish the sensitivity of the diagnostic criteria published by Marais and co-workers in 2010 for childhood tuberculous meningitis (TBM), a retrospective study on children with confirmed TBM was conducted. Methods Between January 2006 and December 2019, children c…
Anuradha Chaudhary, Isampreet Kaur, Harshvardhan Singh, Veetheankashna Gupta
Background: Continuing the fight to eradicate tuberculosis from India, which has 24 per cent of the world’s total number of TB cases, is a big challenge for the country to achieve its goal of being TB free by 2025. Keeping in view limitation of culture and smear microscopy, a rap…
Masawa N, Bani F, Ndege R
…eloping countries. There have been great advancements in TB diagnostics with introduction of the molecular tests such as Xpert MTB/RIF, loop-mediated isothermal amplification, lipoarabinomannan urine strip test, and molecular line-probe assays. However, most of the hospitals in T…
Heba Ahmed Eshmawey, Haytham Mahmoud Emam
Tuberculosis is considered a multisystemic disease as it can attack different organs not only lungs. TB results in high morbidity and mortality .Tubercular pleural effusion belongs to extrapulmonary TB .Examination of Ziehl-Neelsen stained smears of pleural fluid rarely detect Ac…
Matteo MJ, Latini MC, Martinovic DN, Bottiglieri M
The WHO aims to reduce the number of deaths from TB by 95% and decrease its incidence rate by 90% between 2015 and 2035. The recommended rapid diagnostic tests are accurate and cost-effective, allow for a prompt start to treatment, and influence other outcomes that are important …
Han M, Xiao H, Yan L
Background Tuberculous pleurisy (TBP) is the most common form of extrapulmonary tuberculosis (TB). However, rapid diagnostic methods with high accuracy for tuberculous pleurisy are urgently needed. In the present study, we evaluated the diagnostic accuracy of Xpert MTB/RIF, LAMP …
А. В. Мишина, А. В. Мишина, V. Yu. Mishin, V. Yu. Mishin, V. Yu. Mishin, et al.
Aim. To study the features of clinical manifestations and diagnostics of a combination of pulmonary tuberculosis (PTB) and opportunistic lung infections (OLI) in patients in advanced stage of HIV infection with immunodeficiency. Materials and methods. The study included 338 patie…
Maria Angela Vittoria Anna Chiara Licata, Gina Gualano, Annelisa Mastrobattista, Alberto Zolezzi, Stefano Maria De Carli, et al.
<bold>Background:</bold> One of the most frequent form of extrapulmonary tuberculosis (TB) is cervical lymphadenopathy. Very few studies in the literature documented the use of ultrasound-guided needle aspiration biopsy (US-NAB) of neck nodes to diagnose tuberculosis, moreover th…
Vivek Kumar, Manoj Kumar, Gopal Shankar Sahni
…Gene Xpert MTB/ RIF assay has significantly transformed the diagnostics of TB. The present study aimed diagnostic usefulness of CBNAAT for diagnosing pediatric tuberculosis in our hospital setting.
 Material and Methods: This study was carried out at department of Pediatric,…
C Bravo, A Elgogary, L Saravis, V Hoytfox
Abstract Rationale Sarcoidosis is a granulomatous, multisystem inflammatory disease of unknown etiology that most frequently affects the lungs and skin. Erythema nodosum (EN) is the most common non-specific cutaneous manifestation, reported in up to 25% of sarcoidosis cases and o…
Li Z, Wang J, Xiu X, Shi Z, Zhang Q, et al.
Background and purpose Tuberculosis (TB) is the most fatal infectious disease worldwide. Approximately 24.6% of tuberculosis cases are extrapulmonary and predominantly affect the spine. It is difficult to diagnose spinal TB (STB). We aimed to evaluate the diagnostic performance o…
Muyoyeta M, Kerkhoff AD, Chilukutu L, Moreau E, Schumacher SG, et al.
Background A novel, rapid, point-of-care urine-based lipoarabinomannan assay (Fujifilm SILVAMP TB LAM ("FujiLAM")) has previously demonstrated substantially higher sensitivity for tuberculosis (TB) compared with the commercially available Determine TB LAM assay using biobanked sp…
Miyamoto T, Tone K, Inaki S, Saito R, Maeda M, et al.
…ghted image (DWI) images. To investigate novel radiological diagnostics for PTB, we focused on MRI apparent diffusion coefficient (ADC) values, which have not been investigated in this context. The present case showed 0.52 × 10 -3 mm 2 /s; additionally, the mean value of other ma…
Bita S, Kelebi T, Holmes A, Vaccher S, Majumdar SS, et al.
Setting Bacteriological confirmation of TB diagnosis remains a key operational challenge in Papua New Guinea. Sandaun Provincial Hospital (SPH) is the main TB diagnostic and treatment centre of West Sepik Province. Objective To evaluate TB caseload, patient characteristics, and q…
Fernández-Carballo BL, Broger T, Wyss R, Banaei N, Denkinger CM
… (cfDNA) has transformed the field of oncology and prenatal diagnostics. Clinical application of cfDNA for disease diagnosis and monitoring, however, is relatively recent in the field of infectious disease. The potential of cfDNA as a noninvasive diagnostic and monitoring tool is…
Sérgio Monteiro de Almeida, Gislene Maria Botão Kussen, Laura Lúcia Cogo, J. H. de Carvalho, Keite da Silva Nogueira
…dle-income countries. Objectives: We aimed to calculate the diagnostics characteristics of Xpert MTB/RIF for the detection of Mycobacterium tuberculosis in the cerebrospinal fluid (CSF) and the frequency of rifampicin (RIF)-resistance in the CSF samples. Methods: A total of 313 c…