Showing 176–192 of 192 documents
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Lee H, Choi H, Sim YS, Park S, Kim WJ, et al.
…spective cohort studies have been conducted to evaluate the clinical characteristics of Korean patients with bronchiectasis, indicating an urgent need for cohort studies on bronchiectasis. Methods and analysis The Korean Multicenter Bronchiectasis Audit and Research Collaboration…
Putera, Iwan
…g of ocular TB (OTB) by integrating immunological insights, clinical observations, and innovative diagnostic strategies. It combines findings from laboratory studies and patient registries in both Indonesia, a high TB-endemic country, and the Netherlands, a low TB-endemic country…
Mohanad Saleh, Tasneem Mustafa Almashaiekh, Rahaf Wasfi Thabaineh, Rawda Qasrawi, Ikram Aldarabee, et al.
…though it has been reported worldwide, its epidemiology and clinical characteristics in Palestine remain unclear. This study aimed to estimate the incidence, prevalence, and sociodemographic characteristics of sarcoidosis diagnosed between 2019 and 2024 in the southern West Bank …
Samruddhi Suresh Yerunkar, Nicole Hildebrand, Daniel Strech
**OBJECTIVES:** Monitoring systems exist for clinical research transparency in high-income countries, but systematic assessment of these practices in global health (GH) research (GHR) is limited. We evaluated methods for monitoring GHR transparency and engagement. **DESIGN:** Cr…
Vanya Dhagat, MD
… tuberculosis infection. The study will be conducted at one clinical research site in India. The available live tuberculosis vaccine, Bacillus Calmette-Guérin (BCG), provides incomplete protection against pulmonary tuberculosis. For unknown reasons, a BCG revaccination or "boost…
Gavin Churchyard, MD, PhD, Bernard Landry, MPH
…as a Phase II, randomized, double-blind, placebo-controlled trial conducted at 1 site in South Africa. A total of 26 subjects were randomized 1:1 to receive 2 doses of either AERAS-402 at 3 x 10\^10 vp (N=13) or placebo (N=13) on Study Days 0 and 28. Dose-escalation to a second g…
Souleymane Mboup, Robert Wilkinson, Bernard Landry
…(immunogenicity analysis set). This Phase II multi-country trial was conducted as a randomized, double-blind, placebo-controlled trial in 650 HIV-positive adults with no evidence of active TB disease. Subjects were stratified at the time of randomization by whether or not they w…
Eve Denton, Peter Wark, Mark Hew
…gal burden. Observational studies and randomized controlled trials of azoles including Ketaconazole, Itrazonazole, Voriconazole and Posaconazole all show benefit, reducing exacerbations, steroid requirements and total IgE over time.7-9 However, side effects and drug interactions …
Amadou T LY
…mple size, and recruitment strategies for a future efficacy trial of vaccine candidate MTBVAC in young children. MTBVAC is a new TB vaccine candidate based on an attenuated clinical isolate of M. tuberculosis. The clinical development consortium of this EDCTP program is preparin…
Kamini Jain, Claire Wainwright, Alan R Smyth
… improve the selection of antimicrobials, which may lead to clinical benefits. This is an update of a previous review that was first published in 2013 and was updated in 2016 and in 2018. OBJECTIVES: To evaluate the use of bronchoscopy-guided (also known as bronchoscopy-directed)…
Vidya Ganji, Bhushan Kamble, Farzana Mustafa, Naveen Ravi, U Madhusudhan, et al.
… Web of Science and Cochrane Central Register of Controlled Trials. The search items included "Corona virus disease 19", "impact of COVID-19", "SARS-CoV-2", "Tuberculosis", "TB and COVID-19 co-infection", "comorbidities", "prognosis", "incidence", "outcomes" and "risk factors" fo…
Andrew Schmidt, Ziad Bakouny, Chris Labaki, Babar Bashir, Jessica Clément, et al.
…re on COVID-19 severity in oncology patients from the CCC19 registry. Methods: The CCC19 registry (NCT04354701) was used to identify patients with prior BCG exposure. Cohort A received intravesical treatment for bladder carcinoma, and cohort B received prior BCG vaccination. Each…
Camlin CS, Sheira LA, Kwena ZA, Charlebois ED, Agot K, et al.
…ng fishermen in Kenya. Methods The Owete cluster-randomised trial mapped the male social networks of fishermen in three communities along Lake Victoria in Siaya County, Kenya, and identified distinct social networks (clusters) with a highly connected, network-central man (promote…
Awad K, Jaam M, Awaisu A, Stewart D, Rathore HA, et al.
…hree electronic databases (PubMed, Embase, Cochrane), a RCT registry ClinicalTrial.gov, a peer-reviewed journal 'The Lancet Infectious Diseases', and the references of retrieved articles. Interventions delivered by pharmacists alone or as part of multidisciplinary teams were incl…
Kashyap Surender, Bhardwaj Manisha
…culosis (TB) closely mimics sarcoidosis on epidemiological, clinical and radiological grounds. There is a high possibility of labelling a patient with sarcoidosis as tubercular, especially in TB endemic countries. Furthermore, sarcoidosis is a diagnosis of exclusion. It is impera…
Shivanthan Shanthikumar, Sarath Ranganathan, Melanie R. Neeland
… no effective anti-inflammatory therapies routinely used in clinical practice, however, significant resources are allocated to identifying such treatments.1 Cystic fibrosis transmembrane conductance regulator (CFTR) modulator therapy is transforming the care of CF and is now used…
Fronteira I, Pacheco M, Schaltz-Buchholzer F, Ferrinho P
…s administered to all newborns in Portugal. In July 2016, a clinical guideline established that only children under 6 years belonging to high-risk groups should receive BCG. This might have prevented nonvaccinated children from developing trained immunological responses as effect…