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Saskia Janssen, Thanakorn Vongjarudech, Mats O Karlsson, Caryn M Upton, Anthony J Garcia-Prats, et al.
…upporting broader access to the 3HP regimen. **PAN AFRICAN CLINICAL TRIALS REGISTRY:** PACTR202306775627089, registration date June 15, 2023.
Le Wang, Hongsheng Wang, Liangbin Yan, Meiwen Yu, Jun Yang, et al.
…ing. METHODS: We conducted a cluster-randomized, controlled trial to investigate whether single-dose rifapentine is effective in preventing leprosy in household contacts of patients with leprosy. The clusters (counties or districts in Southwest China) were assigned to one of thre…
Goyal JP, Singh S, Bishnoi R, Bhardwaj P, Kaur RJ, et al.
…osis (TB). However, the evidence from randomized controlled trials (RCTs) is inconsistent. Objectives This systematic review and meta-analysis was performed to synthesize evidence regarding role of vitamin D versus placebo for the management of TB. Materials and methods We search…
Manon Lounnas, Eden Ngu Masama, Samuel Beneteau, Kunda Kasakwa, Rodney Kaitano, et al.
…d questionnaire at all sites. This study is registered with ClinicalTrials.gov (NCT04203628) and the Pan African Clinical Trial Registry (PACTR202006814433059). **FINDINGS:** Of the 216 children enrolled between Jan 13, 2020, and Dec 31, 2021, 215 were included in the study and …
Schwab TC, Perrig L, Göller PC, Guebely De la Hoz FF, Lahousse AP, et al.
…ence Core Collection, Global Index Medicus, Google Scholar, ClinicalTrials.gov, and the WHO International Clinical Trials Registry Platform for published and unpublished reports on targeted NGS for drug-resistant tuberculosis from Jan 1, 2005, to Oct 14, 2022, with updates to our…
Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, et al.
…ed) and WHO Global Index Medicus, and the WHO International Clinical Trials Registry Platform (ICTRP) on 3 May 2023 (date of last search for all databases); we placed no restrictions on the language of publication. Selection criteria We included retrospective and prospective coho…
Stephanie Bjerrum, Bada Yang, Johanna Åhsberg, Laura Olbrich, Mathias Weis Damkjær, et al.
…used in isolation for the detection of tuberculosis, but in clinical practice the tests may be used in parallel (i.e. LC-aNAAT in combination with LF-LAM). **OBJECTIVES:** To compare the diagnostic accuracy of the parallel use of LC-aNAAT on respiratory samples and LF-LAM on uri…
Franco JV, Bongaerts B, Metzendorf MI, Risso A, Guo Y, et al.
… WHO Global Index Medicus, as well as the WHO International Clinical Trials Registry Platform (ICTRP) on 3 May 2023 (date of last search for all databases). We placed no restrictions on the language of publication. Selection criteria We included retrospective and prospective coho…
Marcy O, Wobudeya E, Font H, Vessière A, Chabala C, et al.
…ortality. Methods We did a stepped-wedge cluster-randomised trial in 16 hospitals from six countries (Cambodia, Cameroon, Côte d'Ivoire, Mozambique, Uganda, and Zambia) with high incidence of tuberculosis. Children younger than 5 years with WHO-defined severe pneumonia received e…
Singh A, Midha V, Kaur K, Mahajan R, Singh D, et al.
…e for induction of remission at 8 weeks. Trail registration Clinical Trials Registry of India [CTRI/2021/10/037641].
Fu L, Feng Y, Ren T, Yang M, Yang Q, et al.
…ever studied for LTBI. This proof-of-concept study (Chinese Clinical Trials Registry number: ChiCTR2200058346) was the first to explore a novel, rapid, and simple LTBI detection method via breath test on high-pressure photon ionization time-of-flight mass spectrometry (HPPI-TOFMS…
Inbaraj LR, Shewade HD, Daniel J, Srinivasalu VA, Paul J, et al.
… for the studies to be included were; randomized controlled trials or cohort studies that focused on adults with Isoniazid mono-resistant tuberculosis (HrTB) and treated with a Levofloxacin-containing regimen along with first-line anti-tubercular drugs; they should have had a con…
Shangguan Y, Guo W, Feng X, Shi Y, Li X, et al.
… is unclear. Methods We conducted an open-label, randomized trial in China, involving newly diagnosed, drug-susceptible pulmonary TB. The control group was treated with the standard 6-month regimen. The experimental group replaced ethambutol with faropenem for 2 months. The prima…
Leeberk Raja Inbaraj, Vignes Anand Srinivasalu, Mukesh Kumar Sathya Narayanan, Adhin Bhaskar, Jefferson Daniel, et al.
…is, we searched the Cochrane Central Register of Controlled Trials, MEDLINE, Embase, the Science Citation Index and BIOSIS previews, WHO Global Index Medicus, and Scopus databases, for articles published from Jan 1, 1946, to Oct 2, 2023, using specific search terms such as "Tuber…
Juan Víctor Ariel Franco, Maria-Intí Metzendorf, Agostina Risso, Melanie Boeckmann, Sabrina Schlesinger, et al.
… WHO Global Index Medicus, as well as the WHO International Clinical Trials Registry Platform (ICTRP) on 3 May 2023 (date of last search for all databases). We placed no restrictions on the language of publication. Selection criteria: We included retrospective and prospective coh…
Saidi SS, Abdul Manaf R
…s and methods A single-blinded, randomized controlled field trial study design was conducted in Melaka from September 2019 until August 2021, involving newly diagnosed PTB patients. The participants were randomized either into the intervention group (FASTEN intervention) or into …
Marks GB, Nguyen NV, Nguyen PTB, Nguyen TA, Nguyen HB, et al.
…ress. Methods We performed a cluster-randomized, controlled trial in Ca Mau Province, Vietnam, to evaluate the effectiveness of active community-wide screening, as compared with standard passive case detection alone, for reducing the prevalence of tuberculosis. Persons 15 years o…
Jackson-Morris A, Masyuko S, Morrell L, Kataria I, Kocher EL, et al.
…eb of Science, EMBASE, Global Health Database, and selected clinical trials registries. Eligible studies were published between 2010 and December 2022, available in English, and report health service delivery programs or policies for the selected disease dyads in LMICs. We identi…
Adrienne Katrin M Guiang-Valerio, Ma Theresa M Collante, Christine B Bernal
…re warranted to optimize pediatric treatment strategies. **CLINICAL TRIAL REGISTRY NAME AND REGISTRATION NUMBER:** N/A. **SUPPLEMENTARY INFORMATION:** The online version contains supplementary material available at 10.1186/s41927-026-00630-2.
Giller DB, Giller BD, Giller GV, Scherbakova GV, Koroev VV, et al.
…d active TB absence verified with computed tomography (CT). Clinical improvement (sputum negativity, closure of caverna, and lack of reactivation for 3 years) was achieved in 81% of cases. Conclusions Comparing the successful results of this technique in the cohort of multidrug-r…
Zeliang Yang, Zichun Ma, Zubi Liu, Peibo Li, Yuqin Liu, et al.
…ormance of tNGS was robust regardless of specimen types and clinical symptoms. tNGS also showed a detection potential for other coinfecting respiratory pathogens. More than 90% of tNGS-positive individuals gained drug susceptibility results, which were mainly dependent on bacteri…
Wang Q, Pang Y, Jing W, Liu Y, Wang N, et al.
… was the time to sputum culture conversion on solid medium. Clinical outcomes of patients were evaluated at the time of treatment completion. Of the 22 patients in the experimental group, 7 (31.8%) met the treatment criterion of "cure" and 1 (4.5%) "complete treatment," for a tot…
Anthony Harries, Kudakwashe C Takarinda
…ress.METHODS: We performed a cluster-randomized, controlled trial in Ca Mau Province, Vietnam, to evaluate the effectiveness of active community-wide screening, as compared with standard passive case detection alone, for reducing the prevalence of tuberculosis. Persons 15 years o…
Menghang Wu, Xiaorong Yin, Maojun Chen, Yan Liu, Xia Zhang, et al.
…long-term prognosis.The study was registered in the Chinese Clinical Trial Registry on May 16, 2015 (ChiCTR-IOR-15006441).
Menghang Wu, Xiaorong Yin, Maojun Chen, Yan Liu, Xia Zhang, et al.
…long-term prognosis.The study was registered in the Chinese Clinical Trial Registry on May 16, 2015 (ChiCTR-IOR-15006441).