Showing 176–200 of 200 documents
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E. Lynn-Green, Lucía Gutiérrez, Balaji Pathakumari, Virginia P. Van Keulen, Tobias Peikert, et al.
Abstract Non-tubercular mycobacteria (NTM) present a serious challenge in managing lung transplant candidates and recipients. Pretransplant NTM isolation has been associated with post-transplant NTM infection and significantly increased mortality risk. Strategies for managing pre…
Source: Hesseling AC, Purchase SE, Martinson NA, et al. Levofloxacin preventive treatment in children exposed to MDR tuberculosis. N Engl J Med. 2024;391(24):2315-2326; doi: 10.1056/NEJMoa2314318.Investigators from multiple institutions conducted a randomized controlled trial to …
Afful P, Vechey GA, Leta PK, Gbafu FB, Aku FY
Multidrug-resistant Tuberculosis (MDR-TB) remains a global health concern. The disease results in a prolonged treatment and hence, poses a financial burden to affected individuals and their families. The Ghana National TB Control Programme (NTP) has made extensive efforts to cont…
Milton Kumer Saha, Md Lylatul Kadir, Ahsan Mohammed Hafiz, Kazi Hafiz Uddin, Md. Atiqul Islam, et al.
Background: Tuberculosis (TB) remains a primary global health concern, particularly in low- and middle-income countries like Bangladesh, which ranks among the top 30 high-burden nations. Despite national control efforts, regional disparities in TB prevalence persist, especially i…
Radha Gopalaswamy, Vivekanandhan Aravindhan, Shridhar Narayanan, Selvakumar Subbian
In 2023, 10.8 million people fell ill with tuberculosis (TB) with an estimated 1.25 million deaths globally. While 400,000 people were diagnosed with multi-drug resistant (MDR) and/or rifampicinresistant (RR) TB, only 175, 923 of them were started on treatment. Poor treatment cov…
Christopher Dye
Abstract Stable, familiar endemic infections are rarely seen as health emergencies, even though they kill millions of people each year. But there are ways to remedy the neglect, here illustrated by tuberculosis. Because curative treatment is currently the best form of prevention,…
Alissar Al Khatib, Salwa Hassanein, Mohammad Almari, Mohamad Koubar, Suha Fakhreddine
Worldwide, an estimated 10.6 million people (95% UI: 9.9-11.4 million) fell ill with TB worldwide in 2022, up from 10.3 million (95% UI: 9.6-11.0 million) in 2021 and 10.0 million (95% UI: 9.4-10.7 million) in 2020, Therefore, the scenario of downward trend in pre-pandemic may ha…
Christian W. McMillen
Abstract Tuberculosis, caused by Mycobacterium tuberculosis, emerged in Africa about seventy thousand years ago. It accompanied modern humans on their migrations out of Africa, across the Indian Ocean, and then into Eurasia. Tuberculosis affects almost all parts of the body. Its …
Shirsajit Mitra, Partha Jyoti Saikia, Anuja Dutta, Rupam Das, Gokul M. Das, et al.
Abstract Tuberculosis is emerging as a major global health issue for the under-developed regions across the world including India’s North East. Importantly, the incidence of multidrug-resistant (MDR) strain of Mycobacterium tuberculosis (MTB), the causative agent of TB is increas…
Andreea-Daniela Meca, Mária Bogdán, Adrian Camen, Mihail Virgil Boldeanu, Paraschiva Postolache, et al.
Isoniazid, rifampicin, ethambutol and pyrazinamide are administered in combination for at least 6 months in pulmonary tuberculosis (TB) -one of the first causes of death worldwide- and represent the first-line antituberculotic drugs, with different mechanisms of action, efficacy …
Mane SS, Shrotriya P
Tuberculosis (TB) is a communicable disease that is a major cause of ill health and one of the leading causes of death worldwide. Children act as reservoirs of infection out of which future cases develop. Without the successful detection and treatment of TB infection and disease …
Nisha Kumari, Anuj Khatri
TB remains a leading cause of morbidity and mortality in developing countries. The incidence of congenital TB is underestimated. Current recommendations regarding the management of neonates of mothers with tuberculosis are variable and no tangible guidelines have been advised. Co…
Onyeche Vange, E. Uhl, T. Azua E.
…encourage research for the development of new and better TB vaccines by financing the project. Key words: Prevalence, resistance, Mycobacterium tuberculosis, Makurdi.
Suvanand Sahu, Lucica Diţiu, Alimuddin Zumla
…esearch into the development of new diagnostics, drugs, and vaccines. An estimated 4 million people are currently being left behind without being identified and receiving any quality tuberculosis care. These so-called missing people with tuberculosis need to be found and put on e…
Chinenye Esther Okoro, Confort Nnenna Akujobi, Iniekong Philip Udoh, Stellamaris Ojiuzor Ibhawaegbele, Charles Ikechukwu Ezema, et al.
ABSTRACT Tuberculosis, one of the oldest recorded human afflictions, is still one of the biggest killers among the infectious diseases, despite the worldwide use of a live attenuated vaccine and several antibiotics. This study was designed to assess the resistance rate distributi…
Bansal R, Sharma D, Singh R
…culosis. Important aspects related to new anti-TB drugs and vaccines in various stages of clinical development are also covered in this article.
Shweta Tiwari, Ankit Kumar Singh, Aarshu Acharya, Joyabroto Ghosh, Rashmi Prabha Singh
…ycobacterium tuberculosis (MTB). Despite the development of vaccines and antibiotics to cure the disease, it remains a major global problem due to the development of several ingenious pathogenic pathways. This comprehensive review introduces the mechanisms of bacterial pathogenes…
Ibrahim Khalil, Nahid Afrin Nisa, Priyadarshini Deb, Mst Mahmuda Akter, Ferdous Wahid, et al.
…ed deployment of new tools (shorter preventive regimens, TB vaccines). Targeted, gender-responsive, and adaptive strategies are essential for South Asia to meet, and in several countries exceed, WHO End TB Strategy milestones.
Suerie Moon, Marcela Cristina Fogaça Vieira, Kaitlin Large
…hips (PDPs) have succeeded in bringing nearly 80 new drugs, vaccines and diagnostics for neglected diseases through regulatory approval, but arrangements to ensure they reach patients are unclear since the usual commercial incentives do not apply. We conducted a case study of how…
Selvamano Selvaraj, Jayaprakash N S
Tuberculosis (TB) is a highly infectious disease caused by. The World Health Organization (WHO) has reported more than 8 million new or relapse TB cases and 1.25 million deaths in 2023. Even though the global End TB strategy implemented by WHO has reduced the TB incidence rate be…
Mohammad Adil, Syed Suhail Amin, Saima Naaz, Ayesha Sharmeen
Background Leprosy and tuberculosis (TB) share common characteristics, such as acid-fastness of causative bacteria, geographic endemicity, route of spread, large number of asymptomatic infections, and requirement of multiple drugs for long periods of time to prevent resistance an…
Almeida CF, Juno JA
Approximately one-quarter of the global population is estimated to be infected with Mycobacterium tuberculosis. New developments in vaccine design and therapeutics are urgently needed, particularly in the face of multidrug-resistant tuberculosis (TB). In this issue of the JCI, Sa…
Daniela Paasch, Hannah Schevel, Andrea Riehle, Bibiana Costa, Hassan Toufaili, et al.
**OBJECTIVES:** Tuberculosis (TB) remains a global health challenge, with current antibiotic therapies being limited by long treatments, side effects and multidrug-resistant mycobacterial strains. In addition,(), the main causative agent of TB, employs evasion mechanisms particul…
Thorpe J, Sawaengdee W, Ward D, Campos M, Wichukchinda N, et al.
Whole genome sequencing (WGS) of Mycobacterium tuberculosis offers valuable insights for tuberculosis (TB) control. High throughput platforms like Illumina and Oxford Nanopore Technology (ONT) are increasingly used globally, although ONT is known for higher error rates and is les…
Anna Starshinova, Adilya Sabirova, Igor Kudryavtsev, Artem Rubinstein, Arthur Aquino, et al.
Latent tuberculosis infection (LTBI) represents a biologically active yet clinically asymptomatic stage of(Mtb) persistence. This condition is characterized by subtle immunometabolic alterations reflecting the host-pathogen equilibrium. Understanding the mechanisms and biomarkers…