Showing 176–200 of 200 documents
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Bright MR, Curtis N, Messina NL
Background The mechanisms underlying Bacille Calmette-Guérin (BCG) vaccine's protective effects against tuberculosis (TB) are incompletely understood but are proposed to involve a predominantly cell-mediated process. However, there is increasing evidence for the involvement of an…
Yuan J, Tenant J, Pacatte T, Eickhoff C, Blazevic A, et al.
…rtance of identifying optimal T cell targets for protective vaccines. In this study, we describe a novel, Mycobacterium tuberculosis -specific IFN-γ + CD4 + T cell population expressing surface markers characteristic of naive-like memory T cells (T NLM ), which were induced in bo…
Rasha Khoury, A. Gandhi, D Gudaitis, P Gudaitis
Abstract Background Tuberculosis (TB) is a disease caused by Mycobacterium tuberculosis with 7860 cases reported in 2021 in the United State and estimated 13 million people are living with Latent TB infection (LTBI); Early detection of TB infection is crucial to prevent the sprea…
Wenying Hong, Yuan Xu, Lu Wen, Yao Zhou, Chunjun Huang
**OBJECTIVE:** To evaluate the utility and effectiveness of the recombinantfusion protein (EC) skin test for tuberculosis (TB) screening among student populations in high-altitude regions and to provide evidence-based recommendations for optimizing epidemic control strategies. *…
Izanna I, Mohamad Ikhsan S, Mariam M, Siti Hasmah I
Introduction Measles remains a persistent public health concern in Malaysia. Despite sustained high vaccination coverage in states such as Selangor, reported cases continue to increase. This trend suggests a possible shifting age-distribution of measles, a pattern that has been o…
Francesca Montagnani, PhD, MD
The aim of this project is to analyze the potential contribution of IGRA test QuantiFERON-TB Gold In Tube test (QTF-GIT, Cellestis Limited, Carnegie, Victoria, Australia) in the diagnosis of tuberculosis (TB - active or latent) in pediatric subjects (0 and 17 year)s recently expo…
Thomas Volkman, Hamish Graham, Ingrid Laemmle‐Ruff, Shidan Tosif, Marc Tebruegge, et al.
We read with interest the retrospective analysis by Elliot et al.1 comparing the results of tuberculin skin test (TST) and QuantiFERON Gold In-Tube assays in children of a refugee background. Interpretation of TST and interferon-gamma release assays (IGRA) is a perpetual challeng…
Bielecka T, Augustynowicz-Kopeć E, Gonerko P, Gruszczyński P, Korzeniewska-Koseła M, et al.
Since the second half of the 20th century the incidence of tuberculosis has been declining in Poland. Despite this, current epidemiological data still support the need for the continued mass BCG vaccination in Poland in the near future. Apart from the protection against severe he…
Liang X, Cui R, Li X, Ning H, Kang J, et al.
… Compared to the current limited treatment, several subunit vaccines showed immunotherapeutic effects and were included in clinical trials. In this study, a subunit vaccine of Ag85B with a novel mucosal adjuvant c-di-AMP (Ag85B:c-di-AMP) was delivered intranasally to a persistent…
Anung Sri Handayani, Tri Wahju Astuti, Teguh Rahayu Sartono, Maimun Zulhaidah Arthamin, Fransisca Srioetami Tanoerahardjo
Background: BCG vaccination is one way to control tuberculosis (TB) but still poor in efficacy thus new vaccine development is needed. Immunogenicity test is needed in developing new vaccine. The aim of this study was to understand whether the recombinant protein fusion of ESAT-6…
Goletti D, Lee MR, Wang JY, Walter N, Ottenhoff THM
… CoP are expected to be transformative in developing new TB vaccines as they will de-risk vaccine research and development (R&D) as well as human testing at an early stage. In addition, CoP could also help minimizing the need for preclinical studies in experimental animals. Of ke…
Saelee C, Hanthamrongwit J, Soe PT, Khaenam P, Inthasin N, et al.
Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) poses a major threat to the global public health. Importantly, latent tuberculosis infection (LTBI) still impedes the elimination of TB incidence since it has a substantial risk to develop active disease. A multi-stage …
Kurtz T, Feil AC, Nascimento LS, de Oliveira Abreu P, Scotta MC, et al.
Setting Latent tuberculous infection (LTBI) is an important reservoir of disease reactivation that is sufficient to generate new cases for decades. The tuberculin skin test (TST) is an important tool to diagnose LTBI; however, neonatal bacille Calmette-Guérin (BCG) vaccination ma…
Yang Q, Lin M, He Z, Liu X, Xu Y, et al.
Silicosis is a well-established risk factor for Mycobacterium tuberculosis infection. This study aimed to estimate the burden and risk factors of M. tuberculosis infection. Silicosis patients from Zhejiang Province were screened for M. tuberculosis by sputum culture, chest radiog…
Chair persons: Sally Hargreaves (UK), Teymur Noori (Sweden)
Abstract Some migrant populations in European countries face a disproportionate burden of infections (tuberculosis, latent tuberculosis, HIV, hepatitis, parasitic infection) and be under-immunised. Reducing the burden of infection is a key regional priority, yet there are major s…
Ignacio Pérez Catalán, Carmina Martí, María Gil, Patricia Torrent Ramos, Paloma Albiol Viñals, et al.
OBJECTIVE: The immunosuppressive therapies in the treatment of the immune-mediated inflammatory diseases (EIMI) predispose individuals to the tuberculosis, so the screening of latent tuberculosis infection (ITL) and the treatment reduces the likelihood of a progression to an acti…
Kimuda SG, Andia-Biraro I, Sebina I, Egesa M, Nalwoga A, et al.
Antigens from Mycobacterium tuberculosis (M.tb), have been shown to stimulate human B cell responses to unrelated recall antigens in vitro. However, it is not known whether natural M.tb infection or whether vaccination with, Mycobacterium bovis BCG, has a similar effect. This stu…
Singh S, Kishore D, Singh RK, Pathak C, Ranjan K
Endeavors to identify potentially protective variables for COVID-19 impact on certain populations have remained a priority. Multiple attempts have been made to attribute the reduced COVID-19 impact on populations to their Bacillus-Calmette-Guérin (BCG) vaccination coverage ignori…
Emilie Jalbert, Cuining Liu, Vidya Mave, Nancy Lang, Anju Kagal, et al.
…5 million deaths every year. There is great need for new TB vaccines that are more efficacious than the currently licensed BCG vaccine, which provides only limited protection. Our goal was to identify potential targets for new TB vaccines by characterizing the immune responses th…
Sophia B Siddiqui, M.D.
This study will examine how the immune system responds to infection with Mycobacterium tuberculosis bacteria (bacteria that cause tuberculosis) in order to better understand how the germ produces infection and how the immune response might work to control the infection. Only abo…
Starshinova A, Zhuravlev V, Dovgaluk I, Panteleev A, Manina V, et al.
Background The WHO strategy for eradication of tuberculosis (TB) by 2035 (The End TB Strategy) is aimed at an early and precise diagnosis and subsequent effective treatment of TB patients. Currently, there is no gold standard for the diagnosis of latent TB infection. This study e…
Joaquín Miguel Pellegrini, María Paula Morelli, María Isabel Colombo, Verónica García
…on the differences that can be found in immune responses to vaccines consisting of whole bacteria versus those composed of bacterial-derived antigens.Exacerbation of the immune response is detrimental to host tissues and analysis of particular factors that counteract inflammation…
Hanthamrongwit J, Aruvornlop P, Saelee C, Wanta N, Poneksawat P, et al.
Multi-stage tuberculosis (TB) vaccines composed of active- and dormancy-associated antigens are promising to trigger the immune protection against all TB stages. However, scientists are still in quest of the suitable vaccine candidates. In this study, we identified the potential …
Patricia García, Amaya Arrondo, María De Miguel
…ore starting treatment with JAK inhibitors. The inactivated vaccines recommended for patients being treated with JAK inhibitors are pneumococcus, influenza, hepatitis A, hepatitis B, herpes zoster and SARS-CoV-2. Attenuated live vaccines are contraindicated in these patients. Ins…
Kwon KW, Choi HG, Choi HH, Choi E, Kim H, et al.
…ovel candidate as a component of multi-antigenic TB subunit vaccines.