Showing 176–200 of 200 documents
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Mehdi Roshdi Maleki
…ublic neglect and the ability of M. tuberculosis to develop drug resistance have led to the emergence of multidrug-resistant, extensively drug-resistant, and totally drug-resistant strains. These resistances are mainly caused by genetic mutations in antibiotic target genes, which…
Salam El Achkar
…, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year were diagnosed and treated as such.Although Lebanon is a…
Ketema T, Tadesse M, Bonsa Z, Balay G, Kebede W, et al.
Background Early and accurate diagnosis of drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xper…
Akansha Goyal, Hiral Gadhavi, Binita Aring, Summaiya Mullan
… an early diagnosis followed by the rapid identification of drug resistance, in order to treat patients adequately, break the chain of transmission, and avoid the spread of resistant strains. Multidrug-resistant (MDR) Mycobacterium tuberculosis have emerged worldwide and seriousl…
Diriba G, Alemu A, Tola HH, Yenew B, Amare M, et al.
Background The rise of drug-resistant tuberculosis (DR-TB) has presented a substantial challenge to the national tuberculosis (TB) control program. Understanding the epidemiology of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) could help clinicians to adapt MDR-TB tre…
Gina Oda, Cynthia Lucero‐Obusan, Patricia Schirmer, Mark Holodniy
…8, the CDC reported that isoniazid (INH)-resistant and multidrug-resistant Mycobacterium tuberculosis (MDR-TB, ie, resistant to at least INH and rifampin) represented 9.3% and 1.5% of TB cases, respectively, in the United States. Objective: We analyzed the prevalence of drug-resi…
Faeez Muhammad, Laiba Siddiqui, Rabbia Gul
… intercept the proliferation of the disease. In the case of drug- resistant TB, failure to detect the resistance of anti TB drugs may give rise to extensively drug- resistant tuberculosis (XDR-TB). Thus, the rapid detection of drug resistance is vital;, however, the current stand…
Matsui T, Pinhata JMW, Rabello MCDS, Brandão AP, Ferrazoli L, et al.
…bacterium tuberculosis, and the number of new cases of multidrug resistant TB (MDR-TB), pre extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB) has increased considerably worldwide. OBJECTIVES Herein, using 156 M. tuberculosis isolates from 106 p…
Rim Abbas, Ali Salami, Ghassan Ghssein
…oplet nuclei. Unfortunately, there has been an emergence of resistance to strains of such infections, such as multidrug- as well as extensively drug-resistant strains. Healthcare workers (HCWs) are particularly vulnerable to contracting TB due to their direct contact with patient…
Yousra Kherabi, Ole Skouvig Pedersen, Christoph Lange, François Bénézit, Dumitru Chesov, et al.
…orld Health Organization revised of definition of extensive drug-resistant tuberculosis. We aimed to determine treatment outcomes of individuals affected by extensively drug-resistant tuberculosis in Europe. **METHODS:** This observational, retrospective cohort study included pa…
Zhang C, Ouyang Q, Zhou X, Huang Y, Zeng Y, et al.
Background Multidrug-resistant tuberculosis (MDR-TB) has become a big threaten to global health. The current strategy for treatment of MDR-TB and extensive drug resistant tuberculosis (XDR-TB) is with low efficacy and high side effect. While new drug is fundamental for cure MDR-T…
Mohammad Atif, Mohd Maroof, Sankalp Yadav
The emergence of drug-resistant tuberculosis is a major threat to tuberculosis care and control throughout the world. The lack of effective, affordable and safe drugs for the treatment of MDR-TB is a key factor in the inability of programs to boost up their treatment efforts to m…
L.I. Rusakova, Daria Kucheryavaya, Tamara Izmailova
…comes in patients with TB, including multiple and extensive drug resistant TB (MDR/XDR-TB), in the Russian Federation in 2016–2020. Materials and methods. We used data from the state statistical observation and specialized inquiries. Results. During the five years the treatment s…
Ndjeka N, Schnippel K, Master I, Meintjes G, Maartens G, et al.
…an patients with rifampicin-resistant tuberculosis (TB) and resistance to fluoroquinolones and/or injectable drugs (extensively drug-resistant (XDR) and preXDR-TB) were granted access to bedaquiline through a clinical access programme with strict inclusion and exclusion criteria.…
Sergey Saenko, Giller Db, G. V. Shcherbakova, O. Sh. Kesaev, В.В. Короев, et al.
…ehabilitation among patients who underwent surgery for multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis in the long-term period compared with patients who refused surgery and opted solely for conservative management. Material and methods : We analyzed l…
Gain A, Jain AK, Bhalla M, Aggarwal AN, Dhammi IK, et al.
… present study was undertaken to determine the incidence of drug resistance against anti-tubercular drugs among patients from an endemic zone. Methodology: Forty consecutive clinico-radiologically diagnosed patients of osteoarticular tuberculosis (29: spine, 11: extraspinal) were…
Li H, Yuan J, Duan S, Pang Y
…active TB cases majorly relies on various anti-tuberculosis drugs. However, under the selection pressure by drugs, the continuous evolution of Mycobacterium tuberculosis (Mtb) facilitates the emergence of drug-resistant strains, further resulting in the accumulation of tubercle b…
Al-Ghafli H, Al-Hajoj S
…B) remains a public health menace. The emergence of complex drug-resistant profiles, such as multi-drug resistant and extensively drug-resistant MTB strains, emphasizes the need for early diagnosis of resistant cases, shorter treatment options, and effective medical interventions…
Pedersen OS, Holmgaard FB, Mikkelsen MKD, Lange C, Sotgiu G, et al.
Introduction Historically, extensively drug-resistant tuberculosis has been notoriously difficult to treat with devasting outcomes. As we are coming to the end of an era where the 2006 extensively drug-resistant tuberculosis definitions and old treatment regimens are being replac…
Karthick Vedi, N Venkateswaramurthy, P. Dineshkumar, Satheesh Nagendrans
Introduction: Drug-resistant tuberculosis (TB), including multidrug-resistant (MDR-TB) and extensively drug-resistant TB (XDR-TB), poses major global health challenges. Conventional regimens achieve only 50-60% success rates compared to 85% in drug-susceptible TB. This review exa…
Valencia-Trujillo D, Avila-Trejo AM, García-Reyes RL, Narváez-Díaz L, Mújica-Sánchez MA, et al.
Background Drug-resistant tuberculosis (TB) is associated with higher mortality rates in patients with human immunodeficiency virus (HIV). In Mexico, the number of deaths due to TB among the HIV-positive population has tripled in recent years. Methods Ninety-three Mycobacterium t…
Zhao LL, Huang MX, Xiao TY, Liu HC, Li MC, et al.
…explore the prevalence, risk and genetic characteristics of drug-resistant tuberculosis (TB) from a tertiary care TB hospital in China. Patients and methods We carried out a retrospective study including isolates from 189 patients with pulmonary TB at Fuzhou Pulmonary Hospital. A…
Antonino Catanzaro, MD
…ys (line probe, pyrosequencing, and Microscopic Observation Drug Susceptibility Assay \[MODS\]) to detect resistance to first and second-line anti-tuberculosis (TB) drugs in Mycobacterium tuberculosis (Mtb) strains in 7 days or less, allowing for rapid diagnosis of extensively dr…
Alame Emane AK, Guo X, Takiff HE, Liu S
…or tuberculosis to be eradicated, the transmission of Multi-Drug-Resistant and eXtensively Drug Resistant strains of Mycobacterium tuberculosis (MDR and XDR-TB) must be considerably reduced. Drug resistant strains were initially thought to have reduced fitness, and the majority o…
Polsfuss S, Hofmann-Thiel S, Merker M, Krieger D, Niemann S, et al.
Two new drugs, delamanid and bedaquiline, have recently been approved for treatment of multidrug-resistant and extensively drug-resistant (XDR) tuberculosis. Here, we report a case of clofazimine, bedaquiline, and low-level delamanid resistances acquired during treatment of a pat…