Showing 176–200 of 200 documents
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Leya P. Babu, Johnson V Babu, Shaji George, Nimmy Robin, Joicy Jose
…e, development of ADR during treatment and the evolution of drug resistance, etc. The drugs used in treatment have a higher proportion of side effects; hence, the incidence of ADR also escalates due to polypharmacy, extended duration of treatment and the dose used. For identifica…
Li T, Shi T, Sun Y, Chen F, Jiang W, et al.
… article was to determinate the molecular characteristic of drug resistance Mycobacterium tuberculosis (DRTB) strains from extra pulmonary tuberculosis (EPTB). Methods The medical records of patients with EPTB were reviewed and collected from 2006 to 2016. The drug sensitivity of…
Ya-Li Chen, Yu He, Victor Naestholt Dahl, Kan Yu, Yan-An Zhang, et al.
…informatics tools for predicting Mycobacterium tuberculosis drug resistance. A systematic review of PubMed, Embase, Scopus, Web of Science, CINAHL and the Cochrane Library was performed to identify studies reporting the effectiveness of bioinformatic tools for predicting resistan…
Л. В. Панова, E. A. Krushinskaya, Т. Г. Смирнова, E. S. Ovsyankinа, Е. Е. Ларионова
… respiratory tuberculosis with multiple and pre-extensively drug resistance in adolescents depending on the drug susceptibility testing methods. Subjects and Methods. In Group 1 consisting of new patients (16 adolescents), the pathogen was identified in the institute’s laboratory…
Saranathan Rajagopalan, Lahari Das, Donna J Kohlerschmidt, Amy K Rourke, Salika M Shakir, et al.
(MAB) infections are challenging to treat due to high-level resistance to anti-tuberculosis drugs, carbapenems, fluoroquinolones, and tetracyclines. Clarithromycin and amikacin are considered cornerstone drugs for MAB treatment due to their superior efficacy; however, assessing c…
Ali S, Rahman NR, Ashraf, Rumman, Naveed A, et al.
Background Drug-resistant tuberculosis (DR-TB) is a global health challenge, with smoking potentially affecting treatment outcomes. Smoking compromises immune function and may interfere with the pharmacokinetics of anti-TB drugs. Delayed sputum smear and culture conversion are ke…
Thomas SS, Kalia NP, Pethe K
Generation and characterization of drug resistant mutants is a powerful tool in antimicrobial drug discovery for identification of the molecular target of an investigational drug candidate. The method is relatively simple to be conducted in a classical microbiology laboratory. It…
Peng Li, Yan′e Gong, Suli Han, Yuanyuan Du
Objective To understand the distribution and drug resistance of acinetobacter baumannii isolated from patients in the department of critical care, and to provide a reasonable basis for clinical diagnosis and treatment. Methods A total of 1902 specimens were collected from the dep…
Brayan Patiño-Palma, Sandra Chacon-Bambague, Farlhyn Bermudez-Moreno, Carmencita Peña-Briceño, Juan Bustos-Carvajal, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) constitutes a serious threat to global public health due to the increase in strains resistant to multiple drugs, especially isoniazid and rifampicin. This resistance increases mortality, estimated at 25.6% globally, and complica…
Wang DM, Liao Y, Li QF, Zhu M, Wu GH, et al.
…, this study aimed to analyze the clinical characteristics, drug resistance, and pathogen spectrum of patients coinfected with both HIV and NTM in the Chengdu area of China. Methods Data of 59 patients coinfected with both HIV and NTM collected from the Public Health Clinical Cen…
Zhang C, Wu Z, Huang X, Zhao Y, Sun Q, et al.
…there are few reports on the distribution, transmission and drug resistance of Mycobacterium tuberculosis (Mtb) strains in this region. In this study, we performed minimum inhibitory concentration testing for 14 anti-TB drugs and whole-genome sequencing of 713 clinical Mtb isolat…
Yiwang Chen, Jialei Liang, Dongxin Liu, Peng Xu, Qi Jiang, et al.
…enomes to reconstruct the temporal and spatial evolution of drug resistance across China. We observe that resistance mutations to different drugs arose repeatedly, giving rise to hundreds to over a thousand small drug-resistant clades that mostly emerged within the past two decad…
Fang C, Zhang H, He J, Tian X, Zeng S, et al.
…ations in the rrl and rplC genes are widely associated with resistance to LZD. However, in this study, we screened Mycobacterium marinum strains lacking such mutations, indicating the presence of an alternative resistance mechanism. Notably, through whole-genome sequencing, we id…
Subia Akram, Shyam Kumar Masakapalli, Ranjan Kumar Nanda
…ected with laboratory (H37RV, H37Ra) and clinical isolates (drug-resistant: S6, S11 and sensitive: S4, S5) were derived from read out of the 13 C-based proteinogenic amino acid kinetics. Mtb H37Rv (virulent) exhibited higher growth kinetics within A549 cells compared to H37Ra (av…
Zainal Abidin N, Noorizhab MNF, Teh LK, Lim WF, Mohd Noordin N, et al.
…e is believed to contribute to the pathogen's virulence and drug resistance. Here, we report 10 draft genome sequences of clinical M. tuberculosis isolated in Malaysia as the basis for understanding the genome plasticity of the M. tuberculosis isolates.
Leya P. Babu, Nimmy Robin, Johnson V Babu, Joicy Jose, Shaji George
Objective: Adverse drug reaction (ADR) is regarded as one of the major challenges in the treatment of drug-resistant tuberculosis (DR-TB). It can lead to non-compliance or interrupting treatment completion, which can contribute to avoidable morbidity, drug resistance, treatment f…
Yende Mupepe, Nsutier Kolnziam, Izana Pambi, Manyama Katata, Tene Masolo, et al.
…se of mortality for those with TB/HIV co-infection is still resistance to anti-tuberculosis medications, and the factors leading to it are little known because they are less documented. The main aim of this research was to determine the drivers of multi-drug resistance to anti-tu…
Hajissa K, Marzan M, Idriss MI, Islam MA
Drug-resistant tuberculosis (DR-TB) is still one of the most critical issues impeding worldwide TB control efforts. The aim of this systematic review and meta-analysis was to give an updated picture of the prevalence of DR-TB in Sudan. A comprehensive systematic search was perfor…
Min J, Chung C, Lim J, Park JH, Shin KS, et al.
Introduction Drug-resistant tuberculosis (TB) is a global concern. The proper diagnosis and management of drug-resistant TB are critical for improving treatment outcome. Molecular-based genotypic drug-susceptibility testing (DST) was developed to identify drug-resistant TB; howev…
Rajendra Prasad
The rise of drug-resistant tuberculosis poses a severe danger to the global effort to eradicate tuberculosis (DR-TB). Delays in the application of drug susceptibility testing (DST) based on culture led to extended durations of treatment failure and persistent tuberculosis transmi…
Chaitali Dhande, Devanshi Mistry, Anandakrishnan Karthic, Rajshri Singh, Sagar Barage
…but life‐debilitating disease. The continued development of resistance to frontline anti‐TB drugs such as isoniazid and rifampicin threatens the efficacy of currently available treatment procedures. This highlights the need to explore diverse approaches essential for drug develop…
Andi Alfian Zainuddin, Andang Suryana Soma, Muhammad Firdaus Kasim, Sri Ramadany, Irawati Djaharuddin
…on, find out the high-risk areas, and determine the risk of drug-resistant tuberculosis patients based on patient location in 15 districts of Makassar City from Tuberculosis register data of South Sulawesi Provincial Health Office in December 2017 – April 2019 period. Gen Xpert r…
Chiwala G, Liu Z, Mugweru JN, Wang B, Khan SA, et al.
Drug-resistant tuberculosis (DR-TB) poses a new threat to global health; to improve the treatment outcome, therapeutic vaccines are considered the best chemotherapy adjuvants. Unfortunately, there is no therapeutic vaccine approved against DR-TB. Our study assessed the therapeuti…
Kavitha Kumar, Prashant Giribhattanavar, Chandrasekhar Sagar, Shripad A. Patil
…is of tuberculosis (TB), yet the immune dynamics induced by drug-resistant strains remain underexplored. Understanding the host’s immune response to both drug-sensitive and drug-resistant M. tuberculosis isolates is crucial for elucidating the mechanisms of pathogenesis and resis…
Cuilin Shi, Guang‐Hao Niu, Xia-Fang Wang
目前结核病仍然是全球十大死因之一，全球耐药结核病的疫情不容乐观。由于抗结核新药的匮乏，耐药结核病治疗非常困难，治疗时间长，成功率低，因此新型抗结核药物的研发非常迫切。近期除了已被世界卫生组织推荐的治疗耐多药肺结核的新药如利奈唑胺、贝达喹啉及德拉马尼外，还有针对结核分枝杆菌的约17种新化合物正处于不同的临床试验阶段。本文将耐药结核病治疗药物研究进展综述如下。