Showing 176–200 of 200 documents
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Darma Imran, Philip C. Hill, Jacob McKnight, Reinout van Crevel
…r rates among patients with HIV co-infection and those with drug-resistant disease. Most studies of tuberculosis meningitis (TBM) tend to focus on better diagnosis, drug treatment and supportive care for patients in hospital. However, there is significant variability in mortality…
Imran D, Hill PC, McKnight J, van Crevel R
…r rates among patients with HIV co-infection and those with drug-resistant disease. Most studies of tuberculosis meningitis (TBM) tend to focus on better diagnosis, drug treatment and supportive care for patients in hospital. However, there is significant variability in mortality…
Dhruv Gandhi, Viren Amesur, Vaidehi Mehta, Sonal Patil, Dhruv Mamtora, et al.
…idly detect Mycobacterium tuberculosis (MTB) and rifampicin resistance (RR). However, they may yield rifampicin indeterminate (RI) results which pose a significant challenge. Current guidelines suggest performing NAAT on a second sample and treating with first-line antitubercular…
Chu P, Shi J, Shi J, Dong F, Yang H, et al.
…e the bacterial genotypes and alamarBlue to determine their drug susceptibility profiles. Polymerase chain reactions and DNA sequencing were used to identify drug-resistant mutations. Results There were 13 pediatric bacteremia TB patients, 10 of whom were diagnosed with Bacillus …
Molla Y, Wubetu M, Dessie B
… is effectively treated by the first-line anti-tuberculosis drugs. However, most antibacterial drugs are known to induce hepatotoxicity which may limit their adherence and hence lead to the development of mycobacterial drug resistance. Objective The aim of this study was to asses…
Gunasekaran J, Ranjan R, Joshi I, Karlapudi P, Gupta RM
…ch detected Mycobacterium tuberculosis complex (MTBC) , but resistance to rifampicin was not detected. A line probe assay was also done on the sample for first-line drugs, and no resistance was detected for rifampicin or isoniazid. The patient was started on first-line drugs in t…
Stephen Gordon, MD
…sed by the COVID pandemic. TB diagnosis is challenging, and drug treatment can be prolonged, harmful, costly, and complex, especially in the increasingly common context of drug resistant M. tuberculosis. For these reasons an effective vaccine to prevent disease is a global public…
Laura Marinela Ailioaie, Constantin Ailioaie, Gerhard Litscher
…ies in identifying TBM at onset, will delay timely therapy. Drug-resistant TB (DRTB) represents a real threat to public health and is evolving rapidly. Although new drugs have emerged to overcome DRTB, their role in TBM is limited. Our first objective was to update knowledge abou…
Ravichandran M, Rajaram M, Munusamy M
Background Adverse drug reactions (ADRs) to tuberculosis (TB) drugs are a significant concern for medical professionals and health authorities. Adverse events due to drug-resistant TB (DRTB) treatment are among the most important reasons for treatment interruption. Methods This s…
Gopalaswamy R, Shanmugam S, Mondal R, Subbian S
…nostic modalities for TB, including molecular diagnosis and drug-susceptibility testing (DST), are more advanced and possess a higher rate of sensitivity and specificity, compared to the tools available for NTM infections. In general, drug-sensitive TB is effectively treated with…
Getaneh Mengistu, Zinaye Tekeste, Daniel Mehabie, Solomon Tesfaye, Amir Alelign
…on the prevalence, associated risk factors and the level of drug resistant TB. Therefore, this study aimed to determine TB prevalence, identify associated risk factors, and assess rifampicin resistance in Sekota Town, northwest Ethiopia. **METHODS:** A cross-sectional study was …
Amina Zergui, Nacim Bouziani, Kawtar Fidjel, Choubaila Leksir, Yamina Merzouk, et al.
…treatment outcomes were favorable, with a 91% cure rate, 8% drug resistance, and mortality below 1%. Between 2019 and 2023, cure rates improved from 89 to 94%, while resistance declined from 10 to 6%. These findings provide valuable insights into TB trends in Algeria, guiding pub…
Rakesh Kumar, Sweta Muni, Deepak Pankaj, Randhir Kumar, Kumar Saurabh, et al.
…sed for the detection of Mycobacterium tuberculosis and its resistance to rifampicin. It can be offered as a first-line diagnostic modality in suspected cases of extrapulmonary tuberculosis (TB). This study was done to evaluate the diagnostic accuracy of the Xpert MTB/RIF assay f…
Karthikeyan P. Iyengar, Anil Agarwal, Vijay Kumar Jain, Pranav Ish
…act by delaying patient presentation [Figure 1], diagnosis, drug therapy, and surgical interventions in OA-TB, further worsening morbidity. Such effects are even more profound in developing nations like India, where we have a huge existing burden of OA-TB and the emerging burden …
Rajesh Kumar Yadav, Durgesh Kumar, Yogendra Singh Yadav, Dinesh Kumar Singh, Amit Singh, et al.
…ities for improvement in early and fast detection of TB and drug-resistance. Aim: To determine the prevalence of Tubercular cases in clinically diagnosed TB patients and to determine the prevalence of Rifampicin resistance by CBNAAT. Materials and Methods: This prospective observ…
Keragala BSDP, Herath HMMTB, Janapriya GHDC, Vanitha S, Balendran T, et al.
…deficiency virus infection, diabetes, and immunosuppressive drugs, are risk factors for tuberculosis infection. The use of steroids in the treatment of leprosy may increase the susceptibility to develop tuberculosis. Development of rifampicin resistance secondary to monthly rifam…
Ravindran Chetambath
Drug-susceptible tuberculosis (TB) is currently treated with drugs based on recommendations by the WHO in 1971.[1,2] During the first 2 months (intensive phase) daily doses of isoniazid 5 mg/kg, rifampicin 10 mg/kg, pyrazinamide 25 mg/kg, and ethambutol 15 mg/kg are given, follow…
D. K. Chattopadhyay
…etermine the effectiveness of the anti-Tubercular (anti-TB) drug treatment. Materials and Methods: The present observational study was conducted on 180 participants at B.S. Medical College and Hospital, Bankura, West Bengal, India. The participants were divided into three groups:…
Huashan Hospital
… into account the differential ability of anti-tuberculosis drugs to penetrate the brain. With both good central nervous system penetrance and anti-tuberculosis efficacy that have been demonstrated in drug-resistant tuberculosis, linezolid may be a promising antimicrobial in TBM …
Almagambetova A, Yermekbayeva K, Dilmagambetov D, Tanzharykova G, Baisalbayev B
…fluid is today, the optimal method for early diagnosis of a drug-resistant form of exudative pleurisy of tuberculous etiology.
Surya Kant
…me. The next two chapters discuss various issues concerning drug-resistant TB and its surveillance, which is now the talk of the town with its alarming figures. Treatment of TB is an evolving arena with new drugs and changing protocols. This book provides descriptive yet intellig…
Anuj Singhal, Sonal Singh, Arun Kumar Yadav, Amar Tej Atal, Shubham Shukla
… with India (27%) having the maximum burden of the disease. Drug-induced liver injury (DILI) due to antitubercular treatment (ATT) is a serious adverse effect and a major cause of discontinuation of ATT, leading to increased drug resistance, morbidity, and mortality. METHODOLOGY:…
Asfina Andini, Siti Aisah, Much Nurkharistna Al Jihad, Edy Soesanto
…e used purposive sampling with inclusion criteria including drug-sensitive pulmonary TB, currently undergoing intensive phase treatment, experiencing anaemia based on the degree of anaemia according to WHO. Exclusion criteria included extrapulmonary TB, drug-resistant TB, and pre…
Armine Galstyan, Borisov Se, Michail Sinitsyn, Diana Ivanova, Ludmila Slogodskay
…he aim was to analyze the frequency and severity of adverse drug reactions (ADRs) during bedaquiline-containing anti-tuberculosis therapy (ATT) in HIV/TB co-infected patients. <b>Methods:</b> 57 HIV co-infected patients with drug-resistant pulmonary TB (71.9% male, med 36 y.o., M…
Susanna Esposito, Valentina Fainardi, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
…ew pediatric cases annually. The conventional treatment for drug-susceptible TB has long relied on a 6-month multidrug regimen, which is highly effective but associated with challenges in adherence, toxicity, and healthcare burden.To evaluate whether short-course therapy is an ap…