Showing 176–200 of 200 documents
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Nimmo C, Millard J, van Dorp L, Brien K, Moodley S, et al.
…mine are important drugs in the treatment of drug-resistant tuberculosis and are commonly used across southern Africa, although drug susceptibility testing is not routinely performed. In this study, we did a genotypic and phenotypic analysis of drug-resistant Mycobacterium tuberc…
О. М. Raznatovska, V.I. Petrenko, О.S. Shalmin, R.M. Yasinskyi, A.V. Fedorec, et al.
We present our own observation of the multifocal tuberculosis with pre-extensive drug resistance (pre-XDR-TB) development in a patient who was treated in the pulmonary tuberculosis department No. 2 of the Zaporizhzhia’ regional phthisio-pulmonology clinical treatment and diagnos…
Christoph Lange, Yousra Kherabi, Lorenzo Guglielmetti, Raquel Duarte, Gunar Günther
…sistance testing for BPaLM regimen for rifampicin-resistant tuberculosis in Europe”, published in this journal ( 1 Günther G, Guglielmetti L, Kherabi Y, Duarte R, Lange C; Tuberculosis Network European Trials group. Availability of drugs and resistance testing for bedaquiline, pr…
Shuang Wei, M.D.
Rifampicin-resistant tuberculosis (RR-TB) is characterized by a long treatment course, high incidence of adverse reactions, low cure rate and high recurrence rate. This is related to the large number of drugs in the RR-TB treatment regimen, high incidence of adverse reactions and…
Parissa Farnia, Ali Akbar Velayati
…mes with a new definition of pre-extensively drug-resistant tuberculosis (XDR-TB) and XDR-TB. New definitions for pre-XDR and XDR-TB helped to define more precisely groups of TB patients who require complex treatment regimens.[1] The definition of pre-XDR-TB applied to TB caused …
Afsaneh Kaffash, Saeideh Sadat Shobeiri, Elham Pouraslan, Asghar Kazemzadeh, Fatemeh Doost Mohammadi, et al.
…** This ecological study examines epidemiological trends in tuberculosis, multidrug-resistant TB, extensively drug-resistant TB, and latent TB infection across Iran and its provinces from 1990 to 2021, and explores their association with the Human Development Index. **METHODS:**…
Sheikh BA, Bhat BA, Mehraj U, Mir W, Hamadani S, et al.
Tuberculosis (TB) is a prominent infective disease and a major reason of mortality/ morbidity globally. Mycobacterium tuberculosis causes a long-lasting latent infection in a significant proportion of human population. The increasing burden of tuberculosis is mainly caused due to…
Jin Mo Goo, M.D.
…ultralow dose CT scan. Multidrug- or extensively resistant tuberculosis tuberculosis is a major public health threat worldwide and the global burden of drug-resistant tuberculosis is increasing. Drug-resistant tuberculosis is associated with long period and high costs for treatm…
Shuaibu Abdullahi Hudu
Tuberculosis is still the most prevalent infectious cause of mortality, and it has a significant medical, societal, and economic impact MDR-TB is a type of tuberculosis (TB) infection produced by bacteria resistant to at least two of the most important first-line anti-TB treatmen…
Jain P, Garing S, Verma D, Saranathan R, Clute-Reinig N, et al.
Phenotypic testing for drug susceptibility of Mycobacterium tuberculosis is critical to basic research and managing the evolving problem of antimicrobial resistance in tuberculosis management, but it remains a specialized technique to which access is severely limited. Here, we re…
O'Donnell MR, Larsen MH, Brown TS, Jain P, Munsamy V, et al.
A critical gap in tuberculosis (TB) treatment is detection of emergent drug resistance. We hypothesized that advanced phenotyping with whole-genome sequencing (WGS) will detect low-frequency Mycobacterium tuberculosis drug resistance. We assessed a reporter mycobacteriophage (Φ 2…
Zürcher K, Ballif M, Fenner L, Borrell S, Keller PM, et al.
…nd Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory…
Deshpande D, Srivastava S, Bendet P, Martin KR, Cirrincione KN, et al.
…monstrated that benzylpenicillin did not kill Mycobacterium tuberculosis In this study, we found that >64 mg/liter of static benzylpenicillin concentrations killed 1.16 to 1.43 log 10 CFU/ml below starting inoculum of extracellular and intracellular M. tuberculosis over 7 days. W…
Muhammad Akram, Abid Mahmood, Mohammed Khudhair Hasan, Isaac John Umaru, Hind A. Abdulghafoor, et al.
…s. Mainly affecting the lungs (pulmonary TB), Mycobacterium tuberculosis is a slow-growing, acid-fast bacillus that causes tuberculosis. However, it may also affect other organs, such as the lymph nodes, bones, central nervous system, and genitourinary tract. Due to a number of v…
T. I. Cookey, Sofiat Adewuyi-Oseni, I. O. Okonko, K. C. Anugweje
Aim: Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, is a strictly aerobic bacterium that grows fastidiously and slow, which is among the top 10 causes of death globally and the leading cause from a single infectious agent (above HIV/AIDS). Among the deadly…
Inna Friesen, Timo Ulrichs, L. A. Hryshchuk, H. S. Saturska
… to compare the epidemiological situation of chemoresistant tuberculosis in Germany and Ukraine, in addition analyzing the nature and features of chemoresistant tuberculosis in 192 patients treated at the Ternopil Regional TB Dispensary Ukraine during 2017—2018.
 Materials a…
О. А. Пасечник, В. Л. Стасенко
…modeling the further development of the epidemic process of tuberculosis in several regions of the world, including the Russian Federation, indicate an unfavorable prognosis in the spread of multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis. Purpose of…
Анна Старшинова, E. N. Belyaeva, Igor Kudryavtsev, Artem Rubinstein, Leonid P. Churilov, et al.
…Health Organization (WHO), nearly 10.6 million new cases of tuberculosis were detected in 2022, indicating an increase of 3.5 % from the reported 10.3 million in 2021. After the COVID-19 pandemic, the incidence of tuberculosis increased by 3.9 % from 2020 to 2022. According to th…
Ismail N, Ismail F, Omar SV, Blows L, Gardee Y, et al.
… Strategy targets for 2035 are ambitious and drug resistant tuberculosis is an important barrier, particularly in Africa, home to over a billion people. Objective We sought to review the current status of drug resistant tuberculosis in Africa and highlight key areas requiring imp…
Heidary M, Zaker Bostanabad S, Amini SM, Jafari A, Ghalami Nobar M, et al.
Background Nowadays, tuberculosis (TB) is one of the top ten leading causes of mortality worldwide. The emergence of multidrug-resistant (MDR) - and extensively drug-resistant (XDR) - Mycobacterium tuberculosis (M. tuberculosis) is identified as one of the most challenging threat…
Balasundaram Revathi Mani, Usharani Brammacharry, Venkateswari Ramachandra, Suganthi Palavesam, Muthuraj Muthaiah
The emergence of drug-resistant tuberculosis jeopardizes the TB control programme activities globally. Multidrug-resistant TB is defined as tuberculosis strains resistant to at least two first-line drugs, rifampicin (RIF) and isoniazid (INH). Extensively drug-resistant TB refers …
Youngkyoung Lee, Hoonhee Seo, Soyeon Lee, Dongsic Choi, Sukyung Kim, et al.
Tuberculosis remains a severe global health threat, exacerbated by the rising prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis. Despite the urgent need for effective interventions, the development of anti-tuberculosis drugs h…
Mohsen Heidary, Saeed Zaker Bostanabad, Amini SM, Ameneh Jafari, Ghalami Nobar M, et al.
…ran, IranEmail davood_darban@yahoo.comBackground: Nowadays, tuberculosis (TB) is one of the top ten leading causes of mortality worldwide. The emergence of multidrug-resistant (MDR) – and extensively drug-resistant (XDR) – Mycobacterium tuberculosis (M. tuberculosis) …
Linnemann LC, Schaible UE, Dallenga TK
Due to the rise of tuberculosis cases infected with multi and extensively drug-resistant Mycobacterium tuberculosis strains and the emergence of isolates resistant to antibiotics newly in clinical use, host-directed therapies targeting pathogenesis-associated immune pathways adju…
Karan Varshney, Frasso, CPh, Rosemary, DrPH Leader, et al.
Tuberculosis killed more people in 2018 than any other single infectious disease. In recent years, there has been an upsurge in cases of drug-resistant tuberculosis. Considering both that antibiotic resistance has been described as a global crisis, and that strains of tuberculosi…