Showing 176–200 of 200 documents
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Du W, Zhao Y, Zhang C, Zhang L, Zhou L, et al.
…ns can be influenced by the susceptibility of Mycobacterium tuberculosis (MTB) can provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from…
Du W, Zhao Y, Zhang C, Zhang L, Zhou L, et al.
…ns can be influenced by the susceptibility of Mycobacterium tuberculosis (MTB) can provide valuable information for preventing and treating drug resistant tuberculosis (DR-TB). High-throughput 16S rRNA sequencing was employed to analyze the bacteriome in pulmonary TB lesions from…
Muda MR, Albitar O, Harun SN, Syed Sulaiman SA, Hyder Ali IA, et al.
… or relapse among drug susceptible smear-positive pulmonary tuberculosis patients. Several contributing factors have been identified in many studies, but the results varied across regions and countries. Therefore, the current study aimed to develop a predictive model that explain…
Huan Xia, Zaixing Pan, Yun Hong, Qingzhu Zhao, Weili Fan
… aimed to investigate the correlation between Mycobacterium tuberculosis (MTB) genotypes and the severity of pulmonary imaging, and to explore the application of artificial intelligence (AI) in assessing radiological severity in Hainan, China. In this retrospective study, MTB iso…
M. I. Romanova, E. V. Vаniev, D. O. Churkin, A. V. Abramchenko, А. I. Gayda, et al.
…otherapy for drug susceptible rapidly progressive pulmonary tuberculosis in a patient with systemic lupus erythematosus taking glucocorticosteroids on regular basis. Due to adverse events that occurred when using the regimen of first line drugs, the patient discontinued taking fi…
Tafaj S, Mokrousov I, Borroni E, Trovato A, Kapisyzi P, et al.
…bania is a Balkan country with moderate to low incidence of tuberculosis (TB) and very low prevalence of drug resistant TB. Here, we analyzed a country-wide multi-year Mycobacterium tuberculosis collection in order to detect possible dynamic trends of TB in Albania, with a focus …
Wademan DT, Busakwe L, Nicholson TJ, van der Zalm M, Palmer M, et al.
… acceptability of a novel fixed-dose combination (FDC) anti-tuberculosis drug. This study was nested in the SHINE (Shorter treatment for minimal TB in children) trial, which compares the safety and efficacy of treating non-severe drug-susceptible tuberculosis (TB) with a 6 vs. 4 …
Muhammad Farman, Shahid Mehmood Malik, Ali Akgül, Nadeem Salamat
…millions of people die from the airborne infectious illness tuberculosis (TB). Several drug-susceptible (DS) and drug-resistant (DR) forms of the causative agent, Mycobacterium tuberculosis (MTB), are currently common in the majority of affluent and developing nations, particular…
Usharani Brammachary, Venkateswari Ramachandra, Suganthi Palavesam, Vidya Raj Cuppusamy Kapalamurthy, Aaina Muralidhar, et al.
Tuberculosis (TB) remains the most challenging infection to treat worldwide. The contemporary TB regimens consist of 6–9 months of daily doses of four drugs in the existing regimen that is extremely toxic to patients. The purpose of these longer treatments is to eliminate Mycobac…
Amorim G, Jaworski J, Yang J, Cordeiro-Santos M, Kritski AL, et al.
…Genetic polymorphisms have been associated with risk of antituberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil. Methods Participants were followed in Regional Prospect…
Yang Zhou, Bing Zhao, Tao Li, Qian Cheng, Yanlin Zhao, et al.
This study reports an outbreak of Tuberculosis (TB) in a high school in Hunan province, China during January 2017-April 2018. Contact investigation and TB screening were conducted through symptom screening, tuberculin skin testing, chest radiography and smear examination. Identif…
Zh. T. Zhandauletova, Е. И. Никишова, А. O. Мaryandyshev, K. S. Serikbaeva, M. M. Adenov, et al.
…preventive treatment of drug susceptible and drug resistant tuberculosis. Subjects and Methods . The study was carried out in Almaty, the Republic of Kazakhstan; 182 patients from the groups facing the high risk of developing active tuberculosis received preventive tuberculosis t…
Satyendra N. Shukla, Nitin Bhardwaj, Ashutosh Singh
…alized airborne human intracellular pathogen, Mycobacterium tuberculosis ( Mtb ), causes the disease tuberculosis (TB), with one death per second and approximately 10 million cases per year worldwide. Mtb has emerged as a health risk due to its ability to adapt to drugs . The eme…
Ondiro J, Onyangore F, Onyango R, Muema L, Aduda DSO
Background Tuberculosis program effectiveness is majorly measured by disease severity and treatment response without integrating patient perspectives. Yet, it's a critical dimension in clinical decision-making that enhances health worker-patient interactions and increases individ…
Cross, Gail
Tuberculosis (TB) treatment remains prolonged despite highly effective antimicrobial regimens, reflecting persistent host-mediated inflammation and tissue damage. Host-directed therapies (HDTs) have emerged as a complementary strategy to improve treatment response by modulating m…
Giovanna Gabriela Pedroza Rodrigues, Luanna de Ângelis Correia de Sousa, Danielle Martiniano da Silva Rodrigues, Larissa Pereira Dantas da Silva, João Paulo de Lucena Laet, et al.
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains one of the main global public health challenges, worsened by the emergence of strains resistant to conventional treatments. Levofloxacin (LEVO), a fluoroquinolone antibiotic, is an alternative for treating resistant…
Phenlak Kaewthong, Pramote Tragulpiankit, Chareon Chuchottaworn, Sukanya Wattanapokayakit, Suppanut Prakongsup, et al.
…k factors of isoniazid mono-resistance among Thai pulmonary tuberculosis patients. The case-control study was conducted from 18 th September 2017 to 20 th February 2018. Demographic data were collected from medical record review and interview. NAT2 genotypes were collected from s…
Santos F, Pires D, Anes E, Duarte ARC
…ivity of therapeutic liquid formulations prepared with anti-tuberculosis drugs. Tuberculosis therapy presents various pitfalls related, for example, to the administration of prolonged regimens of multiple drugs, different severe adverse effects, low compliance of the patient to t…
Luanna de Ângelis Correia de Sousa, Ana Lúcia Figueiredo Porto, Giovanna Gabriela Pedroza Rodrigues, Jaqueline Rodrigues da Silva, Milena Brandão de Lima, et al.
Rifampicin (RIF) is one of the main drugs used to treat tuberculosis (TB), primarily caused by Mycobacterium tuberculosis (Mtb) and considered one of the world’s deadliest infectious diseases. However, RIF has limitations in solubility and stability, which compromises its therape…
Novi Maulina, Zinatul Hayati, Zulkarnain Zulkarnain, Kartini Hasballah, Ika Waraztuty
Background: Tuberculosis (TB) remains one of the top ten causes of mortality worldwide. It is caused by a single infectious agent, Mycobacterium tuberculosis. Indonesia has the second highest cases globally and has a high burden of rifampicin-resistant (RR-TB). Xpert MTB/RIF has …
Bhaskar A, Kumari A, Singh M, Kumar S, Kumar S, et al.
The currently available anti-tuberculosis treatment (ATT) comprises exclusively of anti-bacterial drugs, is very lengthy, has adverse side effects on the host and leads to the generation of drug-resistant variants. Therefore, a combination therapy directed against the pathogen an…
Elsayed ZM, Eldehna WM, Abdel-Aziz MM, El Hassab MA, Elkaeed EB, et al.
Joining the global fight against Tuberculosis, the world's most deadly infectious disease, herein we present the design and synthesis of novel isatin-nicotinohydrazide hybrids ( 5a-m and 9a-c ) as promising anti-tubercular and antibacterial agents. The anti-tubercular activity of…
Nurlilah Ab Rahman
Tuberculosis is a global disease that carries with it high health and socio-economic burdens onto populations. Millions of people come down with the active form of the disease every year but the proportion of the world population that carries the latent form of this disease is be…
Kumari Neha, Jitender K Malik
One of the eldest human diseases is tuberculosis (TB), for which there is molecular evidence dating back more than 17,000 years. Unfortunately, TB is still one of the top 10 infectious diseases that kill people worldwide, second only to HIV, despite advances in detection and trea…
Chang VK, Imperial MZ, Phillips PPJ, Velásquez GE, Nahid P, et al.
…pentine-moxifloxacin regimen for drug-susceptible pulmonary tuberculosis was safe and effective. The primary efficacy outcome was 12-month tuberculosis disease free survival, while the primary safety outcome was the proportion of grade 3 or higher adverse events during the treatm…