Showing 151–175 of 200 documents
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Christoph Lange, Keertan Dheda, Dumitru Chesov, Anna M. Mandalakas, Zarir Udwadia, et al.
…lopment and in implementation, to reduce the drug-resistant tuberculosis epidemic.1Lange C Dheda K Chesov D Mandalakas AM Udwadia Z Horsburgh Jr, CR Management of drug-resistant tuberculosis.Lancet. 2019; 394: 953-966Summary Full Text Full Text PDF PubMed Scopus (128) Google Scho…
Nawal Salahuddin, MBBS,FCCP
Tuberculosis is a global public health problem. One third of the world's population is infected with tuberculosis (TB) with almost 2 million deaths per year globally. According to the WHO, Pakistan ranks 8th amongst the 22 high TB burden countries, with an estimated prevalence is…
Ameya D. Bendre, Pooja Singh, Swati Jaiswal
Tuberculosis: Recent Updates in Basic Research, Drug Discovery and TreatmentAmeya D. Bendre1, Pooja Singh2*, Swati Jaiswal3*1.Department of Chemistry, S. P. Pune University (formerly known as Pune University), Ganeshkhind, Pune 411007, IndiaCurrent affiliation: Gennova Biopharmac…
Samantha Pillay, Geraint Davies, Marty Chaplin, Margaretha de Vos, Samuel G. Schumacher, et al.
…ibility testing (DST). DST determines whether Mycobacterium tuberculosis bacteria are susceptible or resistant to drugs. Xpert MTB/XDR is a rapid nucleic acid amplification test for detection of tuberculosis and drug resistance in one test suitable for use in peripheral and inter…
Ismail NA, Mvusi L, Nanoo A, Dreyer A, Omar SV, et al.
…tionately high number of cases of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We sought to estimate the prevalence of resistance to tuberculosis drugs in newly diagnosed and retreated patients with tuberculosis provincially and nation…
L.M. Zahaba, M.S. Opanasenko, І. В. Ліскіна, О. V. Теreshkovych, O.O. Melnyk, et al.
…. To clarify the clinical forms of drug-resistant pulmonary tuberculosis with surgical treatment and their relationship with the morphological activity of specific inflammation and the detection of Mycobacterium tuberculosis (MBT) in the surgical material. MATERIALS AND METHODS. …
Ekramy Elmorsy, Basil D. M. Alruwaili, Hatem R. H. Alrwaili, Anwar S. J. Alrawaili, Abdulelah Alanazi, et al.
Background & objectives: Tuberculosis (TB) continues to be a significant global health issue, as an increasing number of individuals are presenting with severe, life-threatening conditions that require admission to intensive care units (ICUs). The management of critical care …
Amish Talwar, Clarisse A. Tsang, Sandy F. Price, Robert Pratt, William L. Walker, et al.
This report reviews the current status of tuberculosis in the United States, noting the declining incidence and describing the populations with the greatest prevalence. This report reviews the current status of tuberculosis in the United States, noting the declining incidence and…
Gudisa Bereda
Medication-resistant tuberculosis is a considerable across-the-board public health challenge that menace’s the substantial advance made in tuberculosis heedfulness and precluding in current decades. Multidrug-resistant tuberculosis is caused by organisms that are resistant to the…
Yaşar Durmuş S, Tanır G, Aydın Teke T, Kaman A, Yalçınkaya R, et al.
Background Smear-positive adults with tuberculosis are the main source of childhood tuberculosis. The evaluation of children exposed to tuberculosis and determination of the disease stages are the cornerstones of managing childhood tuberculosis. Aim To determine the frequency of …
Schnippel K, Ndjeka N, Maartens G, Meintjes G, Master I, et al.
…ddition of bedaquiline to treatment for multidrug-resistant tuberculosis was associated with an increased risk of death in a phase 2b clinical trial, resulting in caution from WHO. Following a compassionate access programme and local regulatory approval, the South African Nationa…
Margherita Bracchi, Clare van Halsema, Frank A. Post, Funmi Awosusi, Alison Barbour, et al.
…f these guidelines is to help physicians manage adults with tuberculosis (TB)/human immunodeficiency virus (HIV) co-infection. Recommendations for the treatment of TB in HIV-positive adults are similar to those in HIV-negative adults. Of note, the term "HIV" refers to HIV-1 throu…
Zhang A, Jumbe E, Krysiak R, Sidiki S, Kelley HV, et al.
Background Rural settings where molecular tuberculosis diagnostics are not currently available need easy-to-use tests that do not require additional processing or equipment. While acid-fast bacilli (AFB) smear is the most common and often only tuberculosis diagnosis test performe…
Abay GK, Abraha BH
Background Tuberculosis is an infectious disease usually caused by Mycobacterium tuberculosis bacteria. The global emergence of mono- or multidrug-resistant tuberculosis and extensively drug-resistant forms of tuberculosis pose a considerable challenge to tuberculosis control pro…
Gudisa Bereda
Mycobacterium tuberculosis strains that are resistant to an elevating number of second-line medicines used to treat multidrug-resistant tuberculosis are becoming a threat to public health worldwide. Recent guidelines recommended at least 20 months of treatment, but recent regimen…
Ngula Monde, Mildred Zulu, Mathias Tembo, Ray Handema, Musso Munyeme, et al.
…tries in sub-Saharan Africa is affected with drug resistant tuberculosis. However, the drug resistant tuberculosis situation over the years has not been described in various regions of the country. Consequently, this study aims to determine the drug resistant tuberculosis burden …
Chen Yang, Guangchuan Dai, Yicheng Guo, Tianzhen Wang, Weiwei Gao, et al.
**BACKGROUND:** Drug-resistant tuberculosis has emerged as a major public health issue that requires immediate attention. NTS is an innovative method that allows for the direct detection of clinical samples without the need for culture. It could provide more accurate, reliable, a…
Jingxian Ning, Rong Wang, Yuchen Pan, Xinru Fei, Wenxin Jiang, et al.
**OBJECTIVE:** Tuberculosis significantly affects human health and longevity. We aimed to systematically synthesize studies to summarize the median survival time range and years of potential life lost (YPLL) among tuberculosis patients. **METHODS:** We searched Web of Science, P…
Amin A, Vartanian A, Yegiazaryan A, Al-Kassir AL, Venketaraman V
Tuberculosis disease is caused by the bacterium Mycobacterium tuberculosis . It is estimated that 10 million people have developed tuberculosis disease globally, leading to 1.4 million deaths in 2019. Treatment of tuberculosis has been especially challenging due to the rise of mu…
Natarajan A, Beena PM, Devnikar AV, Mali S
Tuberculosis (TB), which is caused by bacteria of the Mycobacterium tuberculosis complex, is one of the oldest diseases known to affect humans and a major cause of death worldwide. Tuberculosis continues to be a huge peril disease against the human population and according to WHO…
О.С. Шевченко, Svitlana Matveyeva, Anna Stepanenko, Olexandra Choporova, Olha Pohorielova
PECULIARITIES OF DRUG-RESISTANT TUBERCULOSIS IN UKRAINE AND KHARKIV REGION 
 Shevchenko O., Matveyeva S., Stepanenko A., Choporova O., Pohorielova O.
 Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problem…
Cristina Daniela Marineci, Cristina Elena Zbârcea, Simona Negreș
Tuberculosis is a chronic infection, most often affecting the lungs, which usually manifests after a latency period from primary infection with Mycobacterium tuberculosis. Symptoms are generally nonspecific, with fever, cough, weight loss and malaise. The diagnosis is based on mi…
Mizukoshi F, Kobayashi N, Kirikae F, Ohta K, Tsuyuguchi K, et al.
…stant (isoniazid and/or rifampicin-resistant) Mycobacterium tuberculosis were obtained from 254 patients diagnosed with drug-resistant tuberculosis in Japan from April 2015 to March 2017 in National Hospital Organization hospitals. The 254 patients were approximately 32% of all 7…
Getachew Kahsu Abay, Bahlibi Hailay
Abstract Background Tuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. The emergence of Mono or multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis (XDR-TB), poses a considerable challenge to Mycobacter…
Zürcher K, Reichmuth ML, Ballif M, Loiseau C, Borrell S, et al.
Background Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and whole-genome sequencing (…