Showing 151–175 of 200 documents
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Mussi-Pinhata, M. M., Goncalves, A. L., Foss, N. T.
Lin, H. T.
…lipid antigen for incorporation into multicomponent subunit vaccines. In this study, we utilized the enhanced stability of bicontinuous nanospheres (BCN) to efficiently encapsulate MA for in vivo delivery to MA-specific T cells, both alone and in combination with an immunodominan…
…lipid antigen for incorporation into multicomponent subunit vaccines. In this study, we utilized the enhanced stability of bicontinuous nanospheres (BCN) to efficiently encapsulate MA for in vivo delivery to MA-specific T cells, both alone and in combination with an immunodominan…
Wenping Gong, Jianping Xie, Hao Li, Ashok Aspatwar
…prevention of COVID-19, and the latest progress of novel TB vaccines.BCG: Old tree sprouts new budsAlthough BCG vaccination can effectively protect infants and young children from M. tuberculosis infection, especially in the prevention of severe TB diseases such as disseminated t…
François Nosten, Professor
…pant will receive single or double doses of one of COVID-19 vaccines (Pfizer-BioNTech COVID-19 vaccine, AstraZeneca vaccine or Janssen Ad26.COV2.S COVID-19 vaccine) in the deltoid muscle of the non-dominant arm. Study Duration approximately 1 year. The main focus of this study is…
Mark F. Cotton, Helena Rabie
…. WHO established criteria for introducing new tuberculosis vaccines in 2018, supporting efficacy of at least 50% in adults and adolescents, although acknowledging that a slightly less efficacious vaccine could be beneficial in this population. For infants, a vaccine should be ei…
Helen McShane, Dr
…ce strong cellular immune responses in humans using subunit vaccines. DNA vaccines, recombinant viral vectors and protein/adjuvant combinations all induce both CD4+ and CD8+ T cells, however none of these antigen delivery systems induce high levels of antigen specific T cells, wh…
Helen McShane
…tify a potential correlate of protection. Future candidate vaccines can then be assessed against their capacity to induce such an immune response. Potential risks to human subjects: The general risks to participants in this human pilot study are associated with phlebotomy, vac…
Jinxiang Xi, Xiuhua April
…irus disease 2019 (COVID-19). Up to date, approved COVID-19 vaccines and boosters are all administered intramuscularly. Interests in developing mucosal vaccination have been arising again during this pandemic for its convenience and painless characteristics.2 COVID-19 is known as…
Mangalakumari Jeyanathan, Dominik Fritz, Sam Afkhami, Emilio Aguirre, Karen Howie, et al.
Summary Background Adenoviral (Ad)-vectored vaccines are typically administered via intramuscular injection to humans, but this route of delivery is unable to induce respiratory mucosal immunity which requires respiratory mucosal route of vaccination. However, inhaled aerosol del…
Yue Wang, Weibing Wang
…, treatments, and innovative tools such as new tuberculosis vaccines are urgently needed. Although there have been rapid advances in tuberculosis vaccine clinical research over the past decade, mathematical modelling studies, which can provide a method to predict the potential fu…
Eloise T. M. Filardi, Roberto Carlos Cruz Carbonell, Fernando R. Pavan, Felipe A. Cerni, Manuela B. Pucca
Vaccines represent one of the most significant achievements in medical science, constituting safe preparations or substances developed with the primary purpose of stimulating the immune system (1,2). Their central function is to protect the human body against a myriad of infectio…
François Spertini
…t" vaccination strategies, in which two different candidate vaccines expressing antigens in common are given weeks or months apart, have generated strong and sustained cellular immune responses correlating with an M.tb protective effect in preclinical animal models. In such a "pr…
Allison Portnoy, Rebecca A. Clark, Matthew Quaife, Chathika K. Weerasuriya, Christinah Mukandavire, et al.
…liminating it has proven challenging. Safe and effective TB vaccines that can rapidly reduce disease burden are essential for achieving TB elimination. We assessed future costs, cost-savings, and cost-effectiveness of introducing novel TB vaccines in low- and middle-income countr…
Suraj B. Sable, Vijayakumar Velu, Andreas Kupz
…y mechanism of infection and immune modulation.Nucleic-acid vaccines offer a key advantage: rapid development and flexibility (11,12). A thorough review of DNA and RNA TB vaccines by Kazakova et al. https://doi.org/10.3389/fimmu.2024.1457327 (13) highlights their promise but also…
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
Abstract The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased i…
Helen McShane
…been immunised with various recombinant MVA investigational vaccines including constructs expressing malaria, HIV, hepatitis B and melanoma antigens without significant adverse reactions (Hill, unpublished data). Furthermore, 190 children aged 1-5 years were vaccinated with a rec…
Mohamed E. El Zowalaty, Hossam M. Ashour
…able protection. Currently, there are at least 16 candidate vaccines in various stages of clinical development in the global TB vaccine pipeline, as was reviewed elsewhere.2TuBerculosis Vaccine Initiative (TBVI)Pipeline of Vaccines.https://www.tbvi.eu/what-we-do/pipeline-of-vacci…
Ahmed M. Abbas, Asmaa Abou‐Bakr, Nermeen Bahaa, Sherry Michael, Marco Ghobrial, et al.
Coronavirus Disease-2019 (COVID-19) has become a worldwide emergency and announced as a pandemic recently with variable incidence and mortality in different geographical areas.1 The relationship between COVID-19 and Bacille Calmette Guérin (BCG) vaccine is still under investigati…
Veli Sungono
… Building trained immunity Historically, researchers design vaccines by identifying the “perfect” antigen, molecules that generates long-term, infection-specific responses by the body’s immune system. This then provides immunity on re-encounter with the same disease-causing agent…
Jeong YD, Lee K, Lee S, Park J, Kim HJ, et al.
…d to identify the extent of its association with individual vaccines, thereby contributing to the development of a more effective vaccination program. We used data on vaccine-associated facial paralysis from 1967 to 2023 (total reports, n = 131 255 418 418) from the World Health …
Gokhan Burul, Büşra Tuğçe Tonyalı, İstemi Serin
…dies on early post-HSCT administration of immunostimulatory vaccines have generally shown them to be safe; however, caution is warranted regarding inflammatory responses and increased reactogenicity [4]. In particular, in the presence of immune-modulating factors such as GVHD or …
Leonora Svarça, Sonja Bojadzieva, Premtim Rashiti, Albiona Rashiti
Vaccines are recognized as one of the most effective public health interventions. Routine immunization has resulted in large reductions in vaccine-preventable disease and death. Vaccine-related hypersensitivity reactions are not uncommon. The concern about the occurrence of hyper…
Dinga JN, Akinbobola JS, Afolayan FID, Njoh AA, Kassa T, et al.
…s including healthcare and the purchase and distribution of vaccines. This vulnerable situation has been exacerbated by the COVID-19 pandemic which disrupted and exposed the fragile nature of equitable access to vaccines for childhood immunisation globally. A systematic review an…