Showing 151–175 of 200 documents
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M.D. Zvereva, Sunita Kanash, S.I. Petrova, В. А. Евсеев, Elena Malyarova, et al.
Diagnosis of tuberculosis in children is challenging because of variable clinical symptoms and no specific signs. We report a case of tuberculous osteomyelitis of the ribs, which demonstrates difficulties associated with the diagnosis of generalized tuberculosis in an 8-year-old …
Suba Guruprasad, Mukesh Sanklecha, Rama Yelikar
To study the usefulness of Xpert TB/Rif in diagnosis of childhood tuberculosis in India. Prospective study was including children from 1 month to 18 years of age with clinical suspicion of tuberculosis. All cases were classified as pulmonary and extra pulmonary tuberculosis based…
A Mosses, D Philbert, F Ngadaya, D Solomon, F Msafiri, et al.
Abstract Rationale Tuberculosis (TB) is a significant public health problem in sub-Saharan Africa, affecting individuals of all ages, including children. Tanzania, one of the countries with a high TB burden, faces persistent challenges in the timely diagnosis and treatment of ped…
Yiheyis Genetu, Bethelhem Belay, Workeabeba Abebe
Background: Approximately 81% of all childhood tuberculosis cases occur among 22 high-burden countries and Ethiopia ranks eighth among these high burden countries. The GeneXpert Mycobacterium tuberculosis DNA and resistance to rifampicin (MTB/RIF) test can detect pediatric tuberc…
Ma HW, Lee HS, Ahn JY
The incidence of tuberculosis remains high in South Korea; the management of latent tuberculosis infection (LTBI) has become the prime target for reducing the infection rate. The management of pediatric LTBI is especially crucial because children can serve as a long-term source o…
Dhaked S, Sharma N, Chopra KK, Khanna A, Kumar R
…ovides the extent of patient and health system delays among pediatric tuberculosis (TB) patients. Objectives The study attempted to understand the treatment seeking pathways of pediatric TB patients under revised national tuberculosis control program (RNTCP). Study design and set…
AW Mesman, María José Morán Soto, Julia Coit, Róger Calderón, Juan Aliaga, et al.
Abstract Background Rapid and accurate diagnosis of childhood tuberculosis (TB) is challenging because children are often unable to produce the sputum sample required for conventional tests. Stool is an alternative sample type that is easy to collect from children, and studies in…
The COVID-19 pandemic has affected the diagnosis and treatment of pediatric tuberculosis (TB), which can pose a public health burden if not properly treated. This study aims to find out the risk factors for pediatric TB. The design of this study was cross-sectional, using TB surv…
NanoPin Technologies, Inc.
…stigate the accuracy of the NanoDetect-TB kit in diagnosing tuberculosis (TB) using frozen serum and plasma samples collected from individuals suspected to have TB disease. The main question\[s\] it aims to answer are: * How does this investigational device compare to the gold …
Basile FW, Nabeta P, Ruhwald M, Song R
The current diagnostic abilities for the detection of pediatric tuberculosis are suboptimal. Multiple factors contribute to the under-diagnosis of intrathoracic tuberculosis in children, namely the absence of pathognomonic features of the disease, low bacillary loads in respirato…
Gunawan H, Lamsu G, Achdiat PA, Suwarsa O, Hindritiani R
Multifocal tuberculosis (TB) is rare. The risk of occurrence of multifocal TB is increasing in immunocompromised patients. Cutaneous entanglement in multifocal TB occurs more infrequently, and its association with multifocal TB is scarcely reported. The aim of this case report wa…
Moretó-Planas L, Mahajan R, Fidelle Nyikayo L, Ajack YBP, Tut Chol B, et al.
Background More than half of childhood tuberculosis cases remain undiagnosed yearly. The World Health Organization recommends the Xpert-Ultra assay as a first pediatric diagnosis test, but microbiological confirmation remains low. We aimed to determine the diagnostic performance …
Muhammad Abbud Widitaputra, Retno Asih Setyoningrum, Agus Harianto
Tuberculosis, caused by Mycobacterium tuberculosis, is transmitted through the release of bacteria into the air via respiratory activities, such as breathing and coughing. Untreated latent tuberculosis can act as a reservoir for future infections. Remote regions like Masalembu en…
Yuqing Chen, Hui Tang, Jieyuan Zheng, Qing Yang, Dongsheng Han
Tuberculosis (TB) remains a leading global infectious killer, yet traditional diagnostic methods are inadequate. Acid-fast staining suffers from low sensitivity, and mycobacterial culture requires prolonged incubation because of the slow growth of. PCR-based molecular assays allo…
Andreia Leite, Pollyanna Mafra Soares, Jêniffer Costa Dos Santos, Carla Nunes
Abstract Background Delays in diagnosing tuberculosis lead to longer infectious periods, posing a challenge in tuberculosis control. This is particularly relevant in high incidence areas (critical). Thus, the objectives of this work were to characterize tuberculosis diagnosis del…
Joelma Clotilde Costa Da Silva, Emília Marcelina Dos Santos, Dionisio Mendes, Raquel Duarte
<b>Introduction:</b> Delay in tuberculosis diagnosis implies a delay in its treatment and perpetuation of the transmission chain. This delay may be due to the patient, but it may also be due to the health system. <b>Objectives:</b> This study aimed to identify factors associated …
Zahra Hasan, Sadia Shakoor, Rumina Hasan
…ountries (LMICs) with a high burden of infectious diseases. Tuberculosis (TB), a major source of morbidity and mortality worldwide, was further exacerbated by the COVID-19 pandemic, resulting in up to 1.5 million deaths in 2020 [[1]WHOGlobal tuberculosis report 2021. World Health…
Alshrouf MA, Elifranji ZO, Halayqeh S, Al-Saber M, Karam AM
Introduction Tuberculosis (TB) is one of the most prevalent infectious diseases globally, often presenting with nonspecific symptoms that can obscure diagnosis, especially when it manifests in uncommon sites such as osteoarticular tuberculosis (OA-TB). Case presentation We report…
Stefani Candra Firmanti, Rina Triasih, Tri Wibawa, Sofia Mubarika Haryana
BACKGROUND: The diagnosis of tuberculosis (TB) in children is challenging by the absence of a practical gold standard. Interferon (IFN)-ginducible protein 10 (IP-10) is a chemokine that may serve as the leading candidate marker in child TB diagnosis. The aim of this study is to a…
Damla Sel Coban, Hıncal Özbakır, Berna Avci Yavuz, Berna Kahraman Çetin, Özlem Erdoğan, et al.
To the Editors: Tuberculosis (TB) remains a significant public health concern in children, particularly in endemic regions. However, diagnosis can be challenging due to other respiratory infections that present with similar clinical and radiological features. Here, we report the …
М. С. Опанасенко, O.V. Tereshkovich, S. М. Shalahai, L. І. Levanda, T.V. Kirillova
Pediatric surgeons often to have different indications for the diagnosis and treatment of pathology of the thoracic cavity. Often, only invasive techniques, such as a biopsy, can help diagnose and determine further treatment. One of the reasons for performing thoracic operations …
Sun L, Qi X, Liu F, Wu X, Yin Q, et al.
Objectives Xpert Mycobacterium tuberculosis and rifampicin (MTB/RIF) Ultra assay has increasingly been used in adult tuberculosis diagnosis, but data relating to its diagnostic accuracy in children are lacking. Because a qualified sputum specimen is difficult to obtain in childre…
Peter J Kitonsa, Devan Jaganath
**INTRODUCTION:** Pediatric tuberculosis (TB), especially among children co-infected with HIV, remains a significant global health challenge. Traditional sputum-based diagnostics are less effective in this population due to difficulties in sample collection and paucibacillary dis…
The Lancet Microbe
When approximately 40% of people who develop tuberculosis (4·2 million of an estimated 10·6 million people, in 2021, according to WHO) are not diagnosed, how can the widespread use of sputum smear microscopy for initial diagnosis—a method developed over a century ago—still be jus…
Brilliant Deva Aspada, Komang Agung Irianto Suryaningrat, Pudji Lestari, Primadenny Ariesa Airlangga
Spinal Tuberculosis is a secondary tuberculosis due to hematogenous spread from the primary infection site (lungs) caused by the bacteria Mycobacterium tuberculosis and is chronic-destructive in nature which attacks the spine. Manifestations in the form of deformity can also be c…