Showing 151–175 of 200 documents
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Omar SV, Louw G, Ismail F, Liu X, Ngcamu D, et al.
Drug-resistant tuberculosis (TB) poses a significant public health concern in South Africa due to its complexity in diagnosis, treatment, and management. This study assessed the diagnostic performance of the Xpert MTB/XDR test for detecting drug resistance in patients with TB by …
Ketema T, Tadesse M, Bonsa Z, Balay G, Kebede W, et al.
Background Early and accurate diagnosis of drug resistance, including resistance to second-line anti-tuberculosis (TB) drugs, is crucial for the effective control and management of pre-extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB). The Xper…
Prasitpuriprecha C, Pitakaso R, Gonwirat S, Enkvetchakul P, Preeprem T, et al.
A person infected with drug-resistant tuberculosis (DR-TB) is the one who does not respond to typical TB treatment. DR-TB necessitates a longer treatment period and a more difficult treatment protocol. In addition, it can spread and infect individuals in the same manner as regula…
Salam El Achkar
Tuberculosis (TB) is the first killer infectious disease, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year …
Salam El Achkar
Tuberculosis (TB) is the first killer infectious disease, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year …
Mursheda Akter, Samrein B. M. Ahmed
Background: Bangladesh is ranked 6th among the Tuberculosis high burden countries. Sometimes, pulmonary tuberculosis (PTB) mimics the early symptoms of lung cancer. Developing countries like Bangladesh, with limited diagnostic facilities, often misdiagnose early lung cancer as sm…
David S.C. Hui, Chi Chiu Leung
Respiratory tract infections (RTI), such as community-acquired pneumonia (CAP) and tuberculosis (TB), are important causes of morbidity and mortality. The ongoing outbreaks of Middle East respiratory syndrome coronavirus (MERS-CoV) infection and epidemic waves of avian influenza …
Michael Reid, Eric Goosby, Sebastian Kevany
In September, 2018, the first ever High-Level Meeting of all UN member states made defeating tuberculosis a global political priority.1Stop TB PartnershipUN high-level meeting on TB–key targets and commitments.http://www.stoptb.org/global/advocacy/unhlm_targets.aspDate: 2018Date …
В. Н. Даниленко
In assessing the threats related to the 12 most dangerous infectious diseases, the World Health Organization (WHO) considers the struggle against multidrug-resistant/extensively drug-resistant (MDR/XDR) forms of the causative agent of tuberculosis, Mycobacterium tuberculosis, as …
Ted Lankester
… methods of case finding and case holding, existing and new diagnostics, and the treatment of adults and children. It explains the categories for recording cases and of treatment outcomes. It outlines the community and clinic background to managing cases of multidrug-resistant (M…
Eskild Petersen, Martin Rao, Giuseppe Ippolito, Gina Gualano, Jeremiah Chakaya, et al.
…l be affected by TB by 2022, and to conduct research on new diagnostics, treatments and vaccines required to achieve global TB control (Tiberi et al., 2018Tiberi S. Petersen E. Maeurer M. Ntoumi F. Yeboa-Manu D. Mwaba P. et al.Taking forward the Stop TB Partnership and World Heal…
Xiaomeng Wu, Huiwen Zheng, Yiyi Chen, Bing Zhao, Feina Li, et al.
To characterize the mutation profile of thegene in isoniazid resistance (INH)(MTB) isolates and to evaluate the correlation between specific mutations and resistance levels, a total of 1,337 INHMTB isolates were collected through the Chinese Drug Resistance Surveillance Program (…
Guo Y, Li J, Lin L
…of EDRTB in high SDI regions due to improved treatments and diagnostics. Global predictions suggest a reduction in DRTB burden by 2030, with a focus on early diagnosis and treatment optimization.
Rashid F, Iqbal S, Tahseen S, Zhao Y
Bedaquiline is a key drug recommended by the WHO for the treatment of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant (XDR) TB, and its use could potentially shorten treatment duration with improved outcomes. However, resistance against this drug has incr…
Katale BZ, Rofael S, Elton L, Mbugi EV, Mpagama SG, et al.
Background Whole-genome sequencing (WGS)-based prediction of drug resistance in Mycobacterium tuberculosis has the potential to guide clinical decisions in the design of optimal treatment regimens. Methods We utilized WGS to investigate drug resistance mutations in a 32-year-old …
Wang L, Lim DR, Phelan JE, Reyes LT, Palparan AG, et al.
The Philippines is a high-incidence country for tuberculosis, with the increasing prevalence of multi- (MDR-TB) and extensively-drug (XDR-TB) resistant Mycobacterium tuberculosis strains posing difficulties to disease control. Understanding the genetic diversity of circulating st…
Li X, Li Y, Guo L, Chen Y, Wang G, et al.
Background For a long time, eliminating tuberculosis (TB) has been an enormous challenge in global health. We aim to use the 2021 Global Burden of Disease Study (GBD 2021) to systematically analyze the TB burden in children and adolescents. Methods We used the 2021 GBD to retriev…
Zhang SX, Miao FY, Yang J, Zhou WT, Lv S, et al.
Background Tuberculosis (TB) is a major infectious disease with significant public health implications. Its widespread transmission, prolonged treatment duration, notable side effects, and high mortality rate pose severe challenges. This study examines the epidemiological charact…
K SP, Parivakkam Mani A, S G, Yadav S
Tuberculosis (TB) remains a significant global health concern, particularly with the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). Traditional methods for diagnosing drug resistance in TB are time-consuming and often …
Dorji T, Tshering K, Adhikari L, Jamtsho T, Bhujel P, et al.
Objectives The emergence of multidrug-resistant tuberculosis (MDR-TB) has made the elimination of TB difficult. Currently, there are limited data on MDR-TB and other drug-resistant TB in Bhutan. We aimed to estimate the incidence and explore the potential risk factors associated …
Zhang SX, Wang JC, Yang J, Lv S, Duan L, et al.
Background The co-infection of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and tuberculosis (TB) poses a significant clinical challenge and is a major global public health issue. This study aims to elucidate the disease burden of HIV-TB co-infect…
Yadav S
Drug-resistant tuberculosis is a noteworthy threat to public health, especially in high-burden countries. Management of these types of tuberculosis is lengthy and associated with a number of adverse drug reactions. Pre-extensively drug-resistant tuberculosis is a serious type of …
Dheda K, Mirzayev F, Cirillo DM, Udwadia Z, Dooley KE, et al.
… the DR-TB treatment landscape with the introduction of new diagnostics and therapeutic agents. However, there is limited guidance on understanding and managing various aspects of this complex entity, including the pathogenesis, transmission, diagnosis, management and prevention …
Mokhtar JA, Attallah DM, Jiman-Fatani AA, Al-Rabia MW, Alqarni MA, et al.
…ive data on demographics, clinical features, comorbidities, diagnostics, and outcomes. Data were analyzed using SPSS, with chi-square and logistic regression identifying risk factors. Statistical significance was determined at a threshold of p Results Of the 131 TB patients invol…
Yadav S
…edent for improved availability of reasonably priced drugs, diagnostics, and vaccines for illnesses with widespread outbreaks in nations with limited resources. While patent protection is vital for stimulating innovation, mechanisms to ensure global accessibility to essential med…