Showing 151–175 of 200 documents
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Takumi Kanokogi, Naohisa Urabe, Nozomi Tokita, Hinako Murakami, Masakazu Sasaki, et al.
The incremental diagnostic yield of consecutive sputum nucleic acid amplification tests (NAATs) for pulmonary tuberculosis (PTB) is not well established. We aimed to assess the diagnostic performance of one to three consecutive sputum NAATs in a non-high-tuberculosis-burden setti…
Bankole OT, Ajayi IO
The prevalence of tuberculosis (TB) and human immunodeficiency virus (HIV) coinfection in Nigeria is currently around 19.1%. This indicates that the two diseases are still a burden on the nation"s health. The aim of this study was to evaluate the diagnostic microbiology capacity …
Broger T, Koeppel L, Huerga H, Miller P, Gupta-Wright A, et al.
…ining sputum samples. Funding FIND, the Global Alliance for Diagnostics.
Tehreem Zulfiqar Janjua, Saqib Musharaf, Arooba Zulfiqar Janjua, Faisal Hassan Zahid Chaudhery, Farzeen Bakhtawar, et al.
Pulmonary tuberculosis (PTB) remains a significant public health concern, especially in high-burden countries like Pakistan. Diagnosis becomes particularly challenging in sputum-negative patients, leading to delayed treatment and increased transmission. Bronchoalveolar lavage (BA…
Chang Song, Chunyan Zhao, Dan Luo, Aichun Huang, Chaoyan Xu, et al.
**BACKGROUND:** Tuberculosis (TB) remains a major cause of death in HIV/AIDS patients, where diagnosis is complicated by atypical presentation and paucibacillary disease. Current diagnostic methods have limitations in speed or sensitivity. This study evaluates the diagnostic valu…
Lehman A, Ellis J, Nalintya E, Bahr NC, Loyse A, et al.
…ve of this review is to highlight novel point-of-care (POC) diagnostics and treatment strategies that can facilitate OI screening and prophylaxis for persons with AHD. Methods We reviewed the WHO guidelines for recommendations for persons with AHD. We summarized the scientific li…
Bjørn Waagsbø, Eva Margrethe Buset, Jørn-Åge Longva, Merete Bjerke, Birgitte Bakkene, et al.
Abstract PurposeStudies on aetiology of community-acquired pneumonia (CAP) vary in terms of microbial sampling methods, anatomical locations, and laboratory analyses, since no gold standard exists. In this large, multicentre, retrospective, regional study from Norway, our primary…
S. Lee, Hee Kang, Min-Jung Jung, Sekyoung Park, Ki Nam Lee
Background: This study evaluated the diagnostic yield and positive predictive factors of post-percutaneous core needle biopsy (PCNB) sputum cytology in diagnosing malignancy.Methods: This retrospective study included patients who underwent PCNB at a single center from January 201…
Zhang X, Meng Q, Miao R, Huang P
Background Tuberculous infection of T cell spot test (T-SPOT.TB) and adenosine deaminase (ADA) have a high diagnostic value in pleural effusion for tuberculous pleurisy. However, there were major differences in existing research in regard to the clinical application of the two tr…
Li Y, Luo D, Zheng Y, Liu K, Chen S, et al.
Objective To understand and analyze the factors relating to patient and diagnostic delays among groups with tuberculous pleurisy (TP), and its spatiotemporal distribution in Zhejiang Province. Methods Data of all tuberculous pleurisy patients were collected from the existing Tube…
Nur Azikin Rozali, Ayu Mustikarini
Introduction: Pulmonary tuberculosis (TB) poses a significant global health challenge, necessitating timely and accurate diagnosis. While chest X-ray (CXR) is widely used, its diagnostic accuracy varies. Advanced modalities like computed tomography (CT) and ultrasound offer poten…
François Chappuis, MD, PhD
Tropical fevers have been a diagnostic challenge from the antiquity. Nowadays, despite the availability of good diagnostic capacities, undifferentiated febrile illnesses continue to be a thorny problem for travel physicians. In developing countries, the scarcity of skilled person…
Dr Natasha Naseer
Background: Pulmonary tuberculosis (TB) remains a major global health concern, particularly in high-risk populations such as immunocompromised individuals, children, and close contacts of TB patients. While chest X-ray (CXR) is the conventional screening tool, its sensitivity is …
Dr Takasur Bibi
Female genital tuberculosis (FGTB) is a significant but often underdiagnosed cause of infertility and chronic pelvic morbidity, particularly in developing countries. Conventional diagnostic methods, such as histopathology, often suffer from low sensitivity due to the paucibacilla…
Raju Sarkar, Medha Wadhwa, Dhaval Parmar, Apurvakumar Pandya, Devang Raval, et al.
Introduction: Tuberculosis (TB) continues to be a major worldwide health concern, which is the leading cause of death in nations like India. Despite various efforts to combat TB, effective screening and timely diagnosis remain challenging. The use of Artificial Intelligence (AI) …
H Sekharamahanti, D Nerusu, K Chintharala, L Dankwa
Abstract Rationale Patients with a strong clinical suspicion of pulmonary tuberculosis (PTB) but negative initial spot CBNAAT (GeneXpert) results present a common diagnostic dilemma. Simple, low-cost sampling approaches such as induced sputum or 24-hour pooled sputum may enhance …
Anu Jain, Snigdha Sen, Mahipal Singh, Fatima Abbas, Geetika Kriti Vashishtha, et al.
… analyzed peer-reviewed studies reporting OTB epidemiology, diagnostics, and clinical manifestations. Eleven studies from high-burden regions (India, Pakistan, China, Malaysia) and the USA were included after database searches and application of eligibility criteria. Due to heter…
Suganthi P, Twinkle Dhamecha, Nilam Patel, Vinod Kumar
Background: Bronchial biopsy remains the reference standard for diagnosing pulmonary pathology; however, minimally invasive cytological techniques are increasingly used in clinical practice. This study aimed to determine the diagnostic accuracy of sputum cytology, bronchoalveolar…
Osorio L, Garcia JA, Parra LG, Garcia V, Torres L, et al.
…field validation and implementation in urban areas of rapid diagnostics for vector-borne diseases and other diseases of poverty. Main body A scoping review was conducted. Peer-reviewed and grey literature were searched using terms describing the targeted infectious diseases, diag…
Amy Y Vittor, MD PHD
Tuberculosis (TB) is one opportunistic infection often seen in HIV individuals. In 2013, there were an estimated 31,800 HIV-TB co-infection cases and 6,100 HIV-related deaths due to TB in the Americas. Due to the non-specific nature of its clinical symptoms, TB can be confused wi…
Mohammed Suhail Najm Al-Salam, Farah Akram Mohammed Al-Mahdawi, Ahmed Shakir Ali Al-Wassiti, Mohammed Tareq Mutar
• Sensitivity, specificity, and AUROC analyses confirmed the criteria’s ability to reliably distinguish presumed ocular tuberculosis from non-tuberculous uveitis. • The structured use of mandatory and supportive criteria improved diagnostic consistency and reduced misdiagnosis in…
Hidayat, Muhammad Dafa, Mertaniasih, Ni Made, Yudhawati, Resti
…is of laboratory confirmation methods for tuberculosis (TB) diagnostics. It encompasses historical perspectives and contemporary advancements, offering insights into the evolution of TB diagnosis over time. The review focuses on three primary diagnostic methods: microscopic exami…
Wannarat Pongpirul, Phanupong Phutrakool, Krit Pongpirul
…hese patterns reflect a gradual transition toward molecular diagnostics, which offer improved accuracy but remain underutilized in lower-tier settings. To address these gaps, we incorporated trend analyses confirming significant temporal shifts and propose a tiered TB screening f…
Hafsat U Ibrahim, Rayyan M Garba, Jameel I Ahmad, Kabiru Abdulsalam, Yasir N Jibril, et al.
**BACKGROUND:** Tuberculosis (TB) remains a leading cause of morbidity and mortality in Nigeria, particularly among people living with HIV (PLWH), who face significantly higher risks of developing active TB. Conventional diagnostic methods such as sputum smear microscopy and ches…
Roy A, Infantes-Lorenzo JA, de la Cruz ML, Domínguez L, Álvarez J, et al.
Tuberculosis (TB) in small ruminants is a neglected disease despite its major impact on goat and sheep production and the global public health. The awareness of the role of small ruminants in the epidemiology of animal TB has increased in the last two decades, however, there is a…