Showing 151–175 of 200 documents
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Rachow A, Saathoff E, Mindru R, Popescu O, Lugoji D, et al.
Background The AID line probe assay has shown promising evaluation data on the detection of Mycobacterium tuberculosis as well as 1st- and 2nd-line drug resistance, using isolates and selected clinical samples in previous studies. Methods The diagnostic performance of three AID-m…
Rashda Shabbir, SM Abbas Naqvi, Javaria Saeed, Guljanan, Shazia Shamas, et al.
Aim: To determine the diagnostic accuracy of GeneXpert in pulmonary and extra-pulmonary specimens taking LJ media as the gold standard. Study design and settings: This cross sectional study was undertaken in the Provincial Reference TB Laboratory collaboration with Pathology Depa…
Priya Srivastava
Introduction: Multi drug resistant (MDR) tuberculosis is a major problem worldwide. There is an urgent need to diagnose MDR cases and initiate treatment to interrupt the chain of transmission of Mycobacterium Tuberculosis. Rapid detection of tuberculosis and Rifampicin (RIF) resi…
Qutub M, Aldabbagh Y, Govindan P, Alamoudi E
Abstract Background The prevalence of tuberculosis across Saudi Arabia is variable with western provinces have the highest incidence. This study aimed to determine the epidemiology of tuberculosis in Jeddah, the age and gender distribution and the accuracy of conventional diagnos…
Komakech K, Nakiyingi L, Fred A, Achan B, Joloba M, et al.
Background Mixed M. tuberculosis (MTB) infection occurs when one is infected with more than one clonally distinct MTB strain. This form of infection can assist MTB strains to acquire additional mutations, facilitate the spread of drug-resistant strains, and boost the rate of trea…
Jain S, Sarin R, Vinay V, Sharma D, Saini JK, et al.
Introduction A shift in policy has occurred with the introduction of molecular diagnostic tools for the upfront diagnosis of all cases of tuberculosis, including drug-resistant tuberculosis. The impact of this shift in policy on severity of disease was studied, and comparisons we…
Firoz Ahmad, Niharika Pandey, Kratika Singh, Shad Ahmad, Mohd Khubaib, et al.
<img src=” https://s3.amazonaws.com/production.scholastica/article/90699/large/prnano_1072023gaf.jpg?1701882189”> Tuberculosis is the second most fatal infectious disease; each year, it causes millions of deaths worldwide. Although several anti-TB drugs are currently availa…
Marcin Kołodziej, Dominik Puls, J. Puls, Bartłomiej Pala, Mateusz Gutowski, et al.
Mycobacterium tuberculosis (MT) is a widespread bacterium which usually attacks the lungs causing tuberculous pneumonia, but it can also occupy any other part of our body. One of the MT strains discovered in 1995 in China, known as the Beijing type, is extremely dangerous because…
Dash Manoranjan, Satyajit Samal, Swain Trupti Rekha, Behera Bibhuprasad, Sahu Swapnasarit, et al.
Background: Tuberculosis is the ninth leading cause of death worldwide. India contributes to about one fifth of global TB burden. It is very important to diagnose early and treat tuberculosis to cut down transmission of tuberculosis.Methods: Author conducted a retrospective study…
Sampath P, Rajamanickam A, Thiruvengadam K, Natarajan AP, Hissar S, et al.
Tuberculosis (TB) diagnosis still remains to be a challenge with the currently used immune based diagnostic methods particularly Interferon Gamma Release Assay due to the sensitivity issues and their inability in differentiating stages of TB infection. Immune markers are valuable…
Adam MAM, Ali HMH, Khalil EAG
Introduction hain GenoType MTBDRsl is nucleic acid amplification assay based on reverse hybridization with specific oligonucleotide probes on nitrocellulose strips. MTBDRsl identifies M. tuberculosis complex and detects resistance to fluoroquinolone, second line injectable drugs …
Amer S, El Hefnawy A, Baz A, Okasha H
Tuberculosis diagnosis and drug susceptibility testing (DST) are considered a priority for prompt initiation of effective therapy, increasing the chance of cure, decreasing the development of resistance, and reducing transmission. Aim Our objective was to evaluate currently appli…
de Vos M, Derendinger B, Dolby T, Simpson J, van Helden PD, et al.
Most cases of multidrug-resistant (MDR) tuberculosis (TB) are never diagnosed (328,300 of the ∼490,000 cases in 2016 were missed). The Xpert MTB/RIF assay detects resistance only to rifampin, despite ∼20% of rifampin-resistant cases being susceptible to isoniazid (a critical firs…
Nikolayevskyy V, Kontsevaya I, Nikolaevskaya E, Surkova E, Samchenko S, et al.
Objectives and methods The Xpert® MTB/RIF assay (Cepheid, Sunnyvale, CA, USA) has been in routine use in Odessa Oblast, a region with the highest tuberculosis (TB) incidence in Ukraine, since 2013. We assessed the performance of the assay in routine settings and evaluated its eff…
Kanade S, Solanki M, Thombare S, Nataraj G
Background Genital Tuberculosis is a form of extrapulmonary tuberculosis, which if not diagnosed early can lead to complications. The objective of this study was to determine the sensitivity and specificity of Xpert Mycobacterium tuberculosis/rifampin (MTB/RIF) assay in genital t…
Ardizzoni E, Ariza E, Mulengwa D, Mpala Q, de La Tour R, et al.
Xpert MTB/RIF rapidly detects resistance to rifampicin (RR); however, this test misses I491F-RR conferring rpoB mutation, common in southern Africa. In addition, Xpert MTB/RIF does not distinguish between viable and dead Mycobacterium tuberculosis (MTB). We aimed to investigate t…
Elsy Carvajal, Samantha Escandón, Pelumi Daniel Adewole, Bernardo Castro-Rodríguez, Ángel Sebastián Rodríguez-Pazmiño, et al.
Nigeria ranks as the sixth country globally and the first in Africa with the highest burden of tuberculosis (TB) infection. The emergence and spread of multidrug-resistant TB (MDR-TB) strains have posed significant challenges to effective disease management in the country. In thi…
Ley SD, Pillay S, Streicher EM, van der Heijden YF, Sirgel F, et al.
Eis promoter mutations can confer reduced Mycobacterium tuberculosis kanamycin susceptibility. GenoType MTBDR sl, a widely used assay evaluating this region, wrongly classified 17/410 isolates as eis promoter wild type. Six out of seventeen isolates harbored mutations known to co…
Hiruy N, Melese M, Habte D, Jerene D, Gashu Z, et al.
Objectives This study compared the yield of tuberculosis (TB) among contacts of multidrug-resistant tuberculosis (MDR-TB) index cases with that in drug-sensitive TB (DS-TB) index cases in a program setting. Methods A comparative cross-sectional study was conducted among contacts …
Kozińska M, Skowroński M, Gruszczyński P, Augustynowicz-Kopeć E
The Beijing/W genotype is one of the major molecular families of Mycobacterium tuberculosis complex (MTBC), responsible for approximately 50% of tuberculosis (TB) cases in Far East Asia and at least 25% of TB cases globally. Studies have revealed that the Beijing genotype family …
World Health Organization
Hu Y, Chi Y, Feng X, Yu F, Li H, et al.
This study systematically investigated the performance of MeltPro and next-generation sequencing in the diagnosis of fluoroquinolone (FQ) resistance among multidrug-resistant tuberculosis patients and explored the relationship between nucleotide alteration and the level of phenot…
Ou X, Song Z, Xing R, Zhao B, Pei S, et al.
Introduction Early and accurate diagnosis of tuberculosis (TB) is crucial for initiating timely treatment and preventing new infections. In this study, we introduced the iFIND TBR assay, an automated all-in-one tuberculosis detection approach that simultaneously detect Mycobacter…
Chopra H, Mohanta YK, Rauta PR, Ahmed R, Mahanta S, et al.
Tuberculosis (TB), one of the deadliest contagious diseases, is a major concern worldwide. Long-term treatment, a high pill burden, limited compliance, and strict administration schedules are all variables that contribute to the development of MDR and XDR tuberculosis patients. T…
Schäfer HL, Barker M, Follmann P, Günther A, Hörning A, et al.
Delay in diagnosing multidrug-resistant tuberculosis (MDR-pTB) in children prolongs time to effective treatment. Data on risk factors for pediatric MDR from low-incidence countries are scarce. Retrospective nationwide case-control study to analyze MDR-pTB cases in Germany between…