Showing 151–175 of 200 documents
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Adriana Weinberg, Lisa Aaron, Grace Montepiedra, Timothy R. Sterling, Nahida Chaktoura, et al.
Abstract Background TB is the most common opportunistic infection in PLWH. IPT is recommended for PLWH in endemic areas and for those with LTBI diagnosed by Quantiferon gold-in-tube (QGIT) or tuberculin skin test (TST) in other areas. We report on the performance of QGIT and TST …
Haas MK, Belknap RW
Diagnosing latent tuberculosis (TB) infection (LTBI) is important globally for TB prevention. LTBI diagnosis requires a positive test for infection and negative evaluation for active disease. Current tests measure an immunologic response and include the tuberculin skin test (TST)…
Freund R, Granger B, Francois C, Carcelain G, Ravaud P, et al.
Several tests have been proposed to detect latent tuberculosis (LTB). Objective To evaluate the cost-effectiveness of different interferon-gamma release assays based strategies used to screen LTB before tumour necrosis factor (TNF) blockers initiation. Methods Consecutive patient…
Chakraborty B, Laskar AA, Baruah A, Kumar R, Barbhuiya MA
Tuberculosis (TB) poses a significant public health challenge in India. According to the World Health Organization (WHO), India tops the list of 30 countries responsible for 87% of global TB cases in 2023. Recent data indicates that India's TB incidence rate was 195 cases per 100…
Fariz Nurwidya, Yunita Arliny, Faisal Yunus, Erlina Burhan, Sita Andarini, et al.
Background: Diabetes Mellitus has been identified as one of factors causing increased risks of latent TB infection. The roles of cathelicidin LL-37, 1.25(OH)2D3 as well as their correlation with specific IFN-γ in latent TB has not been extensively identified. Aims and Objectives:…
Nicoleta Anton, Ciprian Danielescu, L.O. Popa, Anisia Iuliana Alexa, Alina Cantemir, et al.
Intraocular Tuberculosis is a Granulomatous Chronic Infection with Mycobacterium tuberculosis with or without systemic involvement. It is a challenge to put a correct diagnosis and to establish a specific therapeutic protocol. We present the case of a patient with a history of Pu…
Amir Buzimkic, Diane E. Heck, Hong Duck Kim
Tuberculosis (TB) is one of the top 10 leading causes of death worldwide responsible for over 1.5 million deaths annually. It is caused by hazardous biological pathogen (i.e., Mycobacterium tuberculosis (MTB)) with single infectious agent, surpassing even HIV/AIDS. Roughly one-qu…
Adu-Gyamfi CG, Snyman T, Makhathini L, Otwombe K, Darboe F, et al.
Introduction The World Health Organization has identified the need for a non-sputum-based test capable of detecting active tuberculosis (TB) as a priority. The plasma kynurenine-to-tryptophan (K/T) ratio, largely mediated by activity of the enzyme indoleamine 2,3-dioxygenase, may…
Salim Can, Ayşe Şahin, Nazan Dalgıç, Deniz Aygün
Abstract Objective This study aimed to investigate interferon-gamma-inducible protein-10 (IP-10) values in serum and urine in pediatric patients in the diagnosis of active tuberculosis (TB) or latent TB infection (LTBI). It also aimed to investigate whether it can be used as a bi…
Clara Moreno, Nieves Martinez Chanza, Lou Gonzalez Garcia, Ana Veron Sanchez, Maxime Ilzkovitz, et al.
**INTRODUCTION:** Immune checkpoint inhibitors (ICIs) improve survival in multiple malignancies but may induce immune-related adverse events (irAEs), including immune-related bronchiolitis (IRB). Radiologic patterns frequently overlap with infectious diseases, particularly tuberc…
Suthirote Meesawat, Suchinda Malaivijitnond, Saradee Warit
Cross-species infectious disease transmission, especially between humans and wildlife, is increasing during the global warming. Tuberculosis (TB) is an air-borne infectious disease that can be transmitted from humans to non-human primates (NHPs), however, no report of TB prevalen…
Abdul-Ghani R, Al-Awadi A, Al-Aghbari N, Al-Mikhlafy AA, Abdulmoghni SS, et al.
Background Tuberculosis (TB) is one of the most widespread infectious diseases worldwide, typically persisting in the body as a latent TB infection (LTBI). Patients with type 2 diabetes have an increased risk of LTBI progressing to active TB. Therefore, this study determined the …
Yaxi Liu, R Wang, H J An, X X Cheng
mRNA is a potential molecular marker for diagnosis of active tuberculosis.
Xu F, Zhang H, Si X, Chen J, Chen Y, et al.
Background There is a global focus on illness diagnosis in smear-negative and latent tuberculosis infectious populations (SN-TB and LTBI). CD27 has been suggested to play a direct role in active TB. Little is known about smear-negative individuals. Here, we tried to investigate w…
Amir Buzimkic, Diane E. Heck, Hong Duck Kim
Tuberculosis (TB) is one of the top 10 leading causes of death worldwide responsible for over 1.5 million deaths annually. It is caused by hazardous biological pathogen (i.e., <em>Mycobacterium tuberculosis</em> (MTB)) with single infectious agent, surpassing even HIV/AIDS. Rough…
Joydeep Samanta, Jhasaketan Meher, Vinay Pandit
A woman in her 60s with seropositive rheumatoid arthritis developed tuberculous arthritis of the wrist following rituximab therapy, despite negative latent tuberculosis (TB) screening. Although rituximab is considered safer than anti-TNF agents in terms of TB risk, this case high…
Wang SH, Rajaram MVS, Trollip A, Wu Q, Ayala D, et al.
The diagnosis of latent tuberculosis (TB) infection (LTBI) is critical to improve TB treatment and control, and the T-SPOT. TB test is a commercial enzyme-linked immunosorbent spot assay used for this purpose. The objective of the study was to increase automation and extend the t…
Sun T, Wu B, Wang J, Yuan T, Huang H, et al.
Background It is important to distinguish those with active Mycobacterium tuberculosis infection (ATB) from latent tuberculosis infection (LTBI) for monitoring and treating the disease. Monocytes play an important role and may undergo morphological changes against active TB infec…
Leung A, Elasir HM, Mahawish KM
Idiopathic retroperitoneal fibrosis is a rare disease. Symptoms include constitutional symptoms and abdominal/flank pain. Causes of retroperitoneal fibrosis include non-infectious and infectious etiologies. Of the infectious etiologies, tuberculous aortitis is an important differ…
Bienvenu Niyongabo, Subhash Hira
aHealth System Strengthening, USAID-Rwanda Integrated Health Systems Activity, Kigali, Rwanda bUniversity of Washington, Department of Global Health & SPH, Seattle, USA. Correspondence to Subhash Hira, MD, MPH, University of Washington, Department of Global Health, PHFI Mumbai, I…
Zühal Metin, Kemal Özyurt, Mustafa Atasoy, Efşan Gürbüz Yontar, Ragıp Ertaş, et al.
Abstract The use of biological agents, particularly anti-TNF-alpha treatments, in psoriasis patients is associated with an elevated risk of tuberculosis (TB). Hence, a comprehensive assessment of latent tuberculosis infection (LTBI) before biologic therapies is imperative. The ob…
Phillip Ssekamatte, Diana Sitenda, Rose Nabatanzi, Marjorie Nakibuule, Davis Kibirige, et al.
**BACKGROUND:** Type 2 diabetes mellitus (DM) increases both the risk of acquiring latent tuberculosis (TB) infection (LTBI) and progression to active TB. The immunological mechanisms underlying the increased susceptibility remain poorly understood. This study aimed to elucidate …
Rosana Agus, Sjafaraenan, Yulianti Samara, Muhammad Nasrum Massi
The main challenge in the management of Tuberculosis (TB) is diagnosing quickly and accurately, especially Latent Tuberculosis Infection (LTBI). LTBI detection was carried out using the Tuberculin Skin Test (TST) and Interferon Gamma Release Assay (IGRA). In TB endemic areas, the…
Stout JE, Wu Y, Ho CS, Pettit AC, Feng PJ, et al.
Background Lack of a gold standard for latent TB infection has precluded direct measurement of test characteristics of the tuberculin skin test and interferon-γ release assays (QuantiFERON Gold In-Tube and T-SPOT.TB). Objective We estimated test sensitivity/specificity and latent…
Kurnick A, Bar N, Maharshak N
Intestinal tuberculosis (TB) may mimic Crohn's disease (CD) and may be overlooked where TB is not endemic. We present a case of an elderly patient with partial small bowel obstruction caused by intestinal TB, initially suspected to have ileal stricturing CD. In our case, the pati…