Showing 151–175 of 200 documents
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Subramanian N, Sagili H, Naik P, Durairaj J
A 30-year-old, multiparous widow, with postpolio residual paralysis, presented with complaints of dull aching abdominal pain for 15 days. Ultrasound showed a mixed echogenic right adnexal mass with free fluid in the pelvis and abdomen. CT abdomen and pelvis revealed partially def…
Fahmi MN, Harti AP
Background Abdominal tuberculosis is an uncommon variant of extrapulmonary tuberculosis. It accounts for 3.5% of extrapulmonary tuberculosis. Diagnosis of abdominal tuberculosis is still a challenge due to its non-specific symptoms. Abdominal tuberculosis and ovarian cancer may s…
Spekker O, Hunt DR, Berthon W, Paja L, Molnár E, et al.
Abnormally pronounced digital impressions (APDIs) on the endocranial surface develop secondary to a prolonged rise in the intracranial pressure. This can result from a number of pathological conditions, including hydrocephalus due to tuberculous meningitis (TBM). APDIs have been …
Nikita Birhman, Nikhil Payal, Manisha Khandait, Mohit Bhardwaj
Abstract Background: Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis , primarily affecting the lungs. While pulmonary TB (PTB) is the most prevalent form, comprising the majority of cases, extrapulmonary TB (EPTB) presents unique diagnostic and the…
Tingting Li, Huanqing Liu, Guolian Zhao, Qian Lei, Zhuhong You, et al.
**BACKGROUND:** Tuberculous pleurisy represents a prevalent form of extrapulmonary tuberculosis and constitutes a significant diagnostic challenge in clinical practice, particularly in endemic regions where it accounts for approximately 20-30% of all PEs. The nonspecific clinical…
Chen Y, Wang Y, Liu X, Li W, Fu H, et al.
Background Early diagnosis of tuberculosis meningitis (TBM) remains a great challenge during clinical practice. The diagnostic efficacies of cerebrospinal fluid (CSF)-based mycobacterial growth indicator tube (MGIT) culture, modified Ziehl-Neelsen (ZN) staining, Xpert MTB/RIF, an…
Isabelle Munyangaju, Lucía Carratalà-Castro, Dulce Osório, Jacob Bigio, Kondwelani John Mateyo, et al.
Diagnosing tuberculosis (TB) in children is challenging due to non-specific symptoms, paucibacillary disease, and difficulty producing sputum. Chest X-rays (CXRs), though widely used, are often inaccessible in low-resource settings and involve radiation. Ultrasound (US) is a radi…
Sayat Quayum, Md Titu Miah, Tanzila Ferdous, Suriya Shahaly, Sayeda Moni Chowdhury, et al.
Background: Tubercular meningitis (TBM) is the most frequent one among the different forms of CNS tuberculosis. Early diagnosis, as well as treatment of tubercular meningitis (TBM), can give an excellent outcome with minimal residual morbidity. Clinical and diagnostic findings of…
Sulaiman T, Medi S, Erdem H, Senbayrak S, Ozturk-Engin D, et al.
Background Tuberculous meningitis (TBM) represents a diagnostic and management challenge to clinicians. The "Thwaites' system" and "Lancet consensus scoring system" are utilized to differentiate TBM from bacterial meningitis but their utility in subacute and chronic meningitis wh…
Yu G, Shen Y, Zhong F, Ye B, Yang J, et al.
Background Loop-mediated isothermal amplification (LAMP) is used to detect pulmonary tuberculosis (PTB); however, the diagnostic accuracy of the LAMP assay for extrapulmonary tuberculosis (EPTB) is unclear. We performed a meta-analysis to evaluate the performance of LAMP in the d…
Tarikul Islam, Ahmed S Alsherbeeny, Latif Rahman, Tanmoy K Saha, Mehedy Hasan
Disseminated skeletal tuberculosis (TB) is an uncommon manifestation of extrapulmonary TB and often presents with non-specific musculoskeletal symptoms, contributing to diagnostic delay and an increased risk of irreversible structural damage. We report a 35-year-old male with dia…
Chinthaka SWGJW, Satarasinghe RL, Senanayake S, Weerarathne WAPSR, Anfaz AAM, et al.
Background Lymphadenopathy is not an uncommon presentation of adult onset Still's disease: it is present in up to two thirds of patients with adult onset Still's disease. The characteristic appearance of lymphadenopathy is described as intense, paracortical immunoblastic hyperpla…
Humairah Medina Liza Lubis, Emni Purwoningsih, Ance Roslina, Muhammad Al Anas
Tuberculous lymphadenitis (TBLN) is the most common form of extrapulmonary tuberculosis. However, the optimal diagnosis using Fine-Needle Aspiration Cytology (FNAC) or excisional biopsy is uncertain. This research aims to improve the diagnostic of TBLN with FNAC and immunocytoche…
Rahayu Widhyasti, Seno Pamungkas, Sapariah Anggraini
Tuberculosis (TB) continues to pose a global health challenge, particularly in tropical and developing regions. Although primarily a pulmonary disease, TB can manifest in extrapulmonary forms, including ocular involvement such as uveitis. This study aims to describe the diagnosti…
Gupta R, Talwar P, Talwar P, Khurana S, Kushwaha S, et al.
Background Numerous in-house and commercial nucleic acid amplification tests (NAAT) have been evaluated using variable reference standards for diagnosis of TBM but their diagnostic potential is still not very clear. Methods We conducted a meta-analysis to assess the diagnostic ac…
Tummidi Santosh, Prashant Sood, Ashok Rattan, Deepa Dave, Puneeta Nagiredla
INTRODUCTION: No study has simultaneously assessed the diagnostic and quantitative performance of the GeneXpert Mycobacterium tuberculosis/resistance to rifampicin (MTB/RIF) assay on pulmonary and extrapulmonary samples processed in an Indian laboratory. We examined this to asses…
Jain R, Gupta G, Mitra DK, Guleria R
Tuberculosis (TB) remains a major global public health problem worldwide. Though Pulmonary TB (PTB) is mostly discussed, one in five cases of TB present are extrapulmonary TB (EPTB) that manifests conspicuous diagnostic and management challenges with respect to the site of infect…
Rajesh Sharma, Richa Sharma, Kotha Poorna Sai
Background: Tuberculous lymphadenitis is the most prevalent form of extrapulmonary tuberculosis (TB), accounting for approximately 30-40% of such cases. Nucleic acid amplification tests (NAATs), such as TrueNAT, offer a highly sensitive and rapid diagnostic method for tuberculous…
Singh GR, Sinha A, Anushweta, Sharma R, Saurabh K, et al.
Background Pulmonary tuberculosis may result in haematogenous and lymphatic extension in case of failure of early detection, or immunocompromised status, leading to extrapulmonary tuberculosis. Rare sites of extrapulmonary tuberculosis include the gastrointestinal tract, musculos…
Sisodia JA, Dedun AR, Patel PK, Muhammad YT
Background The most common form of extrapulmonary tuberculosis (TB) is tuberculous lymphadenitis, which constitutes about 30-40% of all extrapulmonary TB cases. A new diagnostic method like the nucleic acid amplification test (NAAT) is a very sensitive and rapid test for diagnosi…
Paolo Miotto, Francesca Saluzzo, Andrea M Cabibbe, Daniela M Cirillo
…ol. This paper summarizes the latest advances in TB disease diagnostics. We describe mechanisms of drug resistance in, including both well-characterized and emerging pathways. Approaches for the initial detection of active TB disease are discussed, highlighting the key role of nu…
Mamishi S, Pourakbari B, Hosseinpour Sadeghi R, Marjani M, Mahmoudi S
The diagnosis of extrapulmonary tuberculosis (EPTB) poses a significant challenge, with controversies surrounding the accuracy of IFN-γ release assays (IGRAs). This study aimed to assess the diagnostic accuracy of RD1 immunodominant T-cell antigens, including ESAT-6, CFP-10, PE35…
Tuan Manh Ha, Thu Cam Huynh, Tung Viet Le, Anh Tuấn Nguyễn, Cong Hai Nguyen
Background: Tuberculous pleural effusion (TPE) is a common form of extrapulmonary tuberculosis and remains difficult to diagnose, particularly when distinguishing it from malignant and parapneumonic pleural effusions. Although pleural fluid adenosine deaminase (ADA) is widely use…
Shen Y, Fang L, Ye B, Yu G
Background Abdominal tuberculosis (TB) is a severe extrapulmonary TB, which can lead to serious complications. Early diagnosis and treatment are very important for the prognosis and the diagnosis of abdominal TB is still difficult. Methods We searched PubMed, the Cochrane Library…
Anuradha Sulania, Rajani Sharma, Stuti Kansra, Poonam Sharma
Introduction: Tubercular Meningitis (TBM) is a major public health problem that results from the dissemination of Mycobacterium tuberculosis (MTB) to the Cerebrospinal fluid (CSF) and meninges. Despite the availability of effective treatment options, the mortality rate remains hi…