Showing 151–175 of 192 documents
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Christina S. Thornton, Nicole Boechler, Vidhi Desai, Ranjani Somayaji, Swathi Purighalla, et al.
…adian Bronchiectasis and Nontuberculous Mycobacterial (NTM) Registry aims to 1) outline the clinical characteristics and natural history of bronchiectasis in Canada, 2) identify risk factors contributing to disease progression within Canadians, 3) integrate comprehensive clinical…
Theodore G. Liou, Frederick R. Adler, Natalia Argel, Fadi Asfour, Perry Brown, et al.
… fibrosis (CF) disease outcomes would increase the power of clinical trials and contribute to better personalization of clinical assessments. A representative patient cohort would improve searching for believable, generalizable, reproducible and accurate biomarkers. METHODS: We r…
Yuli Lily Hsieh
…ologies to enhance the quality of evidence translation from clinical trial findings into real-world healthcare decisions. Decisions on whether to adopt new healthcare technologies often rely on evidence from randomized controlled trials (RCTs). However, trial and target populatio…
C.A. Celis-Preciado, Simon Leclerc, Martine Duval, Dominic O. Cliché, Pierre Larivée, et al.
…r utility in acute asthma is unclear. We speculate that the clinical and biological response to those treatments varies according to inflammometry and microbiological test results. Methods and analysis An observational longitudinal pilot study with multimodal clinical and transla…
Mukora R, Maraba N, Orrell C, Jennings L, Naidoo P, et al.
…heir treatment journey and help overcome TB-related stigma. Trial registration number Pan African Trial Registry PACTR201902681157721.
Stefano Aliberti, Luigi Ruffo Codecasa, Andrea Gori, Giovanni Sotgiu, Maura Spotti, et al.
…This manuscript describes the protocol of the first Italian registry of adult patients with respiratory infections caused by NTM (IRENE). Methods: IRENE is an observational, multicenter, prospective, cohort study enrolling consecutive adult patients with either a NTM respiratory …
David Gisselquist
…sks for Covid-19 infection. Expedited randomized controlled trials, as done for Covid-19 vaccines, could have assessed their protection against C19 no later than end-July 2020. Methods: On 21 April 2021, I searched trial registries maintained by the US National Institutes of Medi…
Faidra Laskou, Victoria Konzett, Josef S. Smolen, Christopher J. Edwards, Daniel Aletaha, et al.
…e were searched for observational and randomized controlled trials (RCTs) with a primary endpoint of DMARD safety on conventional-synthetic, biological, and targeted-synthetic DMARDs (csDMARDs, bDMARDs, tsDMARDs respectively), as well as glucocorticoids (GC) and biosimilars, publ…
Lovely Jain, Meenakshi Malik, Kulbir Kaur, Sarita Dogra, Abhishek Purohit, et al.
…SE, Scopus, CINHAL, Web of Science, Cochrane Library, major trial registries, and grey literature. We searched for randomized controlled trials, and observational studies, comparing World Health Organization (WHO) approved treatment regimens of 12 months duration (shorter regimen…
Moriarty AS, Louwagie GM, Mdege ND, Morojele N, Tumbo J, et al.
…ng and alcohol, and poor adherence to medication can affect clinical outcomes. Modification of these behaviours is likely to improve TB treatment outcomes and has proven possible using motivational interviewing (MI) techniques or use of short message service (SMS) text messaging.…
Prentice S, Nassanga B, Webb EL, Akello F, Kiwudhu F, et al.
Background Trials done in infants with low birthweight in west Africa suggest that BCG vaccination reduces all-cause mortality in the neonatal period, probably because of heterologous protection against non-tuberculous infections. This study investigated whether BCG alters all-ca…
Enya Daynes, Neil Greening, Salman Siddiqui, Sally Singh
…be recruited to a double-blind, randomised, sham-controlled trial. Both groups will follow an 8-week intervention phase using the device three times per day for 5 min at a time. This will be recorded in a self-reported diary. The device applies a flow resistive load and oscillati…
Stefan Weber, Betsy Wolf, Katharina Manten, Balamugesh Thangakunam, Barney Isaac, et al.
…). Diagnostic potential of a multi-variable model combining clinical and ultrasound findings was explored using generalized mixed methods and random forest approach. (German trial registry DRKS00026636) Findings We included 541 participants of whom 102 (19%) had TB and 1% had HIV…
Stefan Fabian Weber, Rebecca Wolf, Katharina Manten, Balamugesh Thangakunam, Barney Isaac, et al.
… and chest x-ray (CXR). A multivariable model incorporating clinical and ultrasound findings was explored using generalized mixed models and a random forest approach. (Trial registry DRKS00026636). **FINDINGS:** Among 541 participants, 102 (19%) were diagnosed with TB and 1% wer…
Collins Ankunda, Jude Emunyu, Sharon Namasambi, Conrad Sserunjogi, Brendah Kyomuhangi, et al.
…2019–2023). **METHODS:** We conducted a single site registry based study analysing TB patient data from 2019 to 2023, involving 1,051 tuberculosis patients who initiated treatment at Mildmay Uganda Hospital. Descriptive statistics summarized demographics and clinical char…
Yingqi Liu, Huarui Shen
…al fusion [1,2]. There are still no studies to evaluate the clinical efficacy of OLIF in lumbar tuberculosis surgery. Recently, Du et al. [3] performed a retrospective comparative study to evaluate the clinical efficacy of OLIF combined with posterior percutaneous pedicle screw f…
Calabrese LH, Calabrese C, Lenfant T, Kirchner E, Strand V
…nfectious complications were predictable in the light of preclinical models and early clinical trials (i.e., tuberculosis and TNF inhibitors; meningococcus; and eculizumab). While these scenarios can potentially help us in terms of enhancing our predictive powers (higher vigilanc…
Nathalie Lachenal, CCH Hewison, Catherine Berry, CD Mitnick, SM Ali Ahmed, et al.
…ected as part of a pharmacovigilance programme supporting a clinical trial (TB-PRACTECAL; N=552) and a prospective cohort (endTB; N=2,906). We present the birth outcomes as reported to investigators by participants. ETHICS The endTB and TB-PRACTECAL studies were both approved by …
Harshad C Devarbhavi, Raúl J Andrade
…ave been implicated in most cases of acute liver failure in registry studies. **METHODS:** This review summarizes current knowdledge on the acute and chronic outcomes in patients with idiosyncratic DILI and discusses several of the existing prognostic models. **RESULTS AND CONC…
M Tachibana, Shunji Matsuki, Akifumi Kurata, Masato Fukae, Sayaka Shinohara, et al.
…) of valemetostat in healthy Japanese participants. In this trial, 20 participants received two doses of valemetostat 200 mg, once alone and once after repeated daily doses of rifampicin 600 mg. Coadministration with rifampicin decreased the maximum plasma concentration ( C max )…
Njovu IK, Nalumaga PP, Ampaire L, Nuwagira E, Mwesigye J, et al.
… will also collect baseline data, including demographic and clinical history, using a patient-reported questionnaire. Altogether, this approach will contribute to a diagnostic-based observational study. The primary outcome will be the overall fungal and bacterial diagnostic profi…
Adas MA, Alveyn E, Cook E, Dey M, Galloway JB, et al.
… treatment-associated infection risk is essential to inform clinical decision-making. Areas covered We summarize current literature on infection rates among the licensed JAKi using published phase II/III trial results, post-licensing and registry data. Expert opinion licensed JAK…
Gupta-Wright A, Corbett EL, van Oosterhout JJ, Wilson D, Grint D, et al.
…pragmatic, multicentre, double-blind, randomised controlled trial in two hospitals in Malawi and South Africa. We included HIV-positive medical inpatients aged 18 years or more who were not taking tuberculosis treatment. We randomly assigned patients (1:1), using a computer-gener…
Bryan L Peacker, Jonathan C Hwang, Rebecca I Hartman
…uld consider either including these patients in prospective trials or attempting to collect data via registries to provide more clarity on the management of immunologically vulnerable patients with melanoma.
D Munce, W Elmaraachli, V Chen, A E Brunton, A Geyer, et al.
…iagnoses enrolled in the US Bronchiectasis and NTM Research Registry (BRR). Patients not receiving NTM treatment during the baseline period were excluded, with baseline defined as the 2-year period prior to enrollment. Patients were grouped by treatment regimen: clofazimine-conta…