Showing 151–175 of 200 documents
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Suraj B. Sable, Vijayakumar Velu, Andreas Kupz
…y mechanism of infection and immune modulation.Nucleic-acid vaccines offer a key advantage: rapid development and flexibility (11,12). A thorough review of DNA and RNA TB vaccines by Kazakova et al. https://doi.org/10.3389/fimmu.2024.1457327 (13) highlights their promise but also…
Fadel Sayes, Wafa Frigui, Alexandre Pawlik, Cécile Tillier, Magali Tichit, et al.
Abstract The currently licensed anti-tuberculosis (TB) vaccine, Mycobacterium bovis BCG, provides limited protection against pulmonary TB in adolescents and adults, the main cause of TB transmission and mortality. To obtain an improved BCG-based vaccine candidate with increased i…
Helen McShane
…been immunised with various recombinant MVA investigational vaccines including constructs expressing malaria, HIV, hepatitis B and melanoma antigens without significant adverse reactions (Hill, unpublished data). Furthermore, 190 children aged 1-5 years were vaccinated with a rec…
Ahmed M. Abbas, Asmaa Abou‐Bakr, Nermeen Bahaa, Sherry Michael, Marco Ghobrial, et al.
Coronavirus Disease-2019 (COVID-19) has become a worldwide emergency and announced as a pandemic recently with variable incidence and mortality in different geographical areas.1 The relationship between COVID-19 and Bacille Calmette Guérin (BCG) vaccine is still under investigati…
Veli Sungono
… Building trained immunity Historically, researchers design vaccines by identifying the “perfect” antigen, molecules that generates long-term, infection-specific responses by the body’s immune system. This then provides immunity on re-encounter with the same disease-causing agent…
Jeong YD, Lee K, Lee S, Park J, Kim HJ, et al.
…d to identify the extent of its association with individual vaccines, thereby contributing to the development of a more effective vaccination program. We used data on vaccine-associated facial paralysis from 1967 to 2023 (total reports, n = 131 255 418 418) from the World Health …
Gokhan Burul, Büşra Tuğçe Tonyalı, İstemi Serin
…dies on early post-HSCT administration of immunostimulatory vaccines have generally shown them to be safe; however, caution is warranted regarding inflammatory responses and increased reactogenicity [4]. In particular, in the presence of immune-modulating factors such as GVHD or …
Leonora Svarça, Sonja Bojadzieva, Premtim Rashiti, Albiona Rashiti
Vaccines are recognized as one of the most effective public health interventions. Routine immunization has resulted in large reductions in vaccine-preventable disease and death. Vaccine-related hypersensitivity reactions are not uncommon. The concern about the occurrence of hyper…
Dinga JN, Akinbobola JS, Afolayan FID, Njoh AA, Kassa T, et al.
…s including healthcare and the purchase and distribution of vaccines. This vulnerable situation has been exacerbated by the COVID-19 pandemic which disrupted and exposed the fragile nature of equitable access to vaccines for childhood immunisation globally. A systematic review an…
Agopian A, Young H, Quinlan S, Rice MM
…ases not only requires high coverage but also requires that vaccines are administered in a timely manner. Prior studies have examined the timing of vaccinations in Armenia and found that although vaccination coverage is high, children are not receiving the vaccinations in a timel…
Rhonita Schutz
Tuberculosis (TB) has many known risk factors that contribute to its persistence worldwide, particularly in developing countries. Aotearoa New Zealand (NZ), as a high-income country, is fortunate to fall in the low-risk category. However, the incidence of TB is more common in par…
Gurudeeban Selvaraj, Satyavani Kaliamurthi, Dongqing Wei
…hus providing a promising foundation for next-generation TB vaccines (1). This work also exemplifies how integrating pathogen genomics with host response profiling can accelerate rational vaccine design.Building on the theme of precision, the second study focuses on cervical canc…
José Victor Bortolotto Bampi, Ghislaine Gonçalez de Araujo Arcanjo, Karina Marques Santos, Michele Souza Ventura, Everton Ferreira Lemos, et al.
…obal threat, with unequal burden across populations. New TB vaccines are in development, and people deprived of liberty (PDL) represent a vulnerable group that may benefit from vaccination. This study evaluated acceptability of a hypothetical new TB vaccine and factors associated…
Sharma A, Kerkhoff AD, Haambokoma M, Shamoya B, Sikombe K, et al.
…ves To estimate intention to receive newly introduced adult vaccines among community members and healthcare workers (HCWs) in Lusaka, Zambia in the context of previous COVID-19 vaccine uptake and perceived disease threat and, identify trusted sources of vaccine information. Metho…
Eleni I. Katsarou, George C. Fthenakis
…inst staphylococcal mastitis’ and ‘total number of optional vaccines administered’. Univariable and multivariable analyses were first performed to establish associations of each of the above outcomes with climatic variables. Then, the same approach was employed to assess the impo…
Palmer MV, Hwang S, Kanipe C, Putz EJ, Fernandes LGV, et al.
…ablished technique used for stabilizing bioproducts such as vaccines. Methods In the current study, cattle were vaccinated in two phases. In each phase, cattle were divided into three groups. Group 1 received BCG injected SQ, Group 2 received liquid BCG delivered to the posterior…
Sasheela Ponnampalavanar, Anjanna Kukreja, Sazali Basri, Sheron Sir Loon Goh, Syifa’ Ahmad Faisol, et al.
Background and objectives: Since the introduction of the COVID-19 vaccine through the National COVID-19 Immunization Program in Malaysia in February 2021, the number of cases of severe COVID-19 and mortality have progressively decreased. We explored the association between vaccin…
Puck T. Pelzer, Marit Holleman, Michelle E. H. Helinski, Ana Lúcia Weinberg, Pauline Beattie, et al.
…t populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial…
Pelzer PT, Holleman M, Helinski MEH, Weinberg AL, Buis J, et al.
…t populations. To accelerate the clinical development of TB vaccines, a directory of clinical trial centres was established in sub-Saharan Africa (SSA) to assess capacity for conducting late-stage TB vaccine trials. Methods TB vaccine-related parameters were identified, and trial…
Akhil Sharma, Shaweta Sharma, Mobeen Shaik, Hrithik Dey, Pankaj Agrawal
…including influenza, COVID-19, or tuberculosis, traditional vaccines such as oral formulations and injections have limitations in effectively targeting these pathogens. However, the solution to this challenge lies in the development of inhalable vaccines. Inhalable vaccines take …
Badurdeen S, Marshall A, Daish H, Hatherill M, Berkley JA
Importance Bacillus Calmette-Guérin (BCG) vaccination is commonly delayed in infants who are preterm and have low birth weights (LBW) despite the association of early vaccination with better vaccination coverage and potentially nonspecific benefits for survival. Objective To dete…
Veronika A. Petrova, Leyla S. Namazova-Baranova, Мarina V. Fedoseenko, Dina S. Rusinova
…). It has also been shown that timely vaccination with both vaccines in the early neonatal period significantly reduces the risk of AD in general infant population compared to non-vaccinated individuals or those who had only one vaccine (odds ratio [OR] 0.374; 95% confidence inte…
Ting Huang, Master
…esign. In this trial, 160 subjects were enrolled. The test vaccines are divided into four dose groups: dose group 1 (0.025mg / 0.1ml / person), dose group 2 (0.05mg / 0.1ml / person), dose group 3 (0.075mg / 0.1ml / person), dose group 4 (0.1mg / 0.1ml / person), each Each dose …
Xie Y, Tian X, Zhang X, Yao H, Wu N
Vaccines are known to function as the most effective interventional therapeutics for controlling infectious diseases, including polio, smallpox, rabies, tuberculosis, influenza and SARS-CoV-2. Smallpox has been eliminated completely and polio is almost extinct because of vaccines…
Jia Q, Masleša-Galić S, Nava S, Horwitz MA
… attenuated L. monocytogenes multiantigenic M. tuberculosis vaccines, especially the rLm5Ag(30) vaccine expressing a fusion protein of 23.5/Mpt64, TB10.4/EsxH, ESAT6/EsxA, CFP10/EsxB, and r30, enhances BCG-induced protective immunity against M. tuberculosis aerosol challenge. In …