Showing 151–175 of 200 documents
Sorted by hybrid relevance (keyword + semantic via RRF)
Ferluga J, Yasmin H, Al-Ahdal MN, Bhakta S, Kishore U
…hage, perpetrating TB. However, BCG and new recombinant BCG vaccines have the capacity, as indicated in pre- and clinical trials, to overcome such Mtb evasion. Various strategies include pro-inflammatory-bactericidal type 1 polarisation (M1) phenotype of the infected macrophage, …
Sakiyama M, Kozaki Y, Komatsu T, Niwa K, Suzuki H, et al.
Introduction Tuberculin skin test (TST) has been used to diagnose tuberculosis (TB) and latent tuberculosis infection (LTBI). However, in Bacillus Calmette-Guérin (BCG) vaccinated patients, TST tends to produce false-positive results. According to the previous vaccination schedul…
Manjula Singh, Sindhu Joshi, Vikram Vohra, Rohit Sarin, Suchit Vasant Kamble, et al.
… in participants with tuberculin skin test positivity. Both vaccines were well tolerated with mild local reactions in about a third of participants. VPM1002 and Immuvac inducedspecific polyfunctional CD4+ T cells. Post hoc analyses showed vaccine efficacy of 64.6% (95% CI 16.3% t…
Background Many people infected with the Mycobacterium tuberculosis complex (the bacteria that cause tuberculosis [TB]) have an inactive stage of infection known as latent tuberculosis infection (LTBI). A person with LTBI is at risk of developing active TB. Screening for, and tre…
Richard Long, Malcolm King, Alexander Doroshenko, Courtney Heffernan
…ating. Instructive, because without effective treatments or vaccines, the most successful COVID-19 containment responses have demanded the early and rigorous application of basic public health principles. These include timely surveillance, widespread testing, contact tracing and …
Shen Gwan Han, MD
Tuberculosis is still the most common infectious disease in Taiwan. The infants in Taiwan have been vaccinated at birth with BCG -Tokyo 171 strain since 1951. The BCG vaccination rate is 97% among first grade students in a recent national survey. Even with such a high BCG vaccina…
Background: complex (the bacteria that cause tuberculosis [TB]) have an inactive stage of infection known as latent tuberculosis infection (LTBI). A person with LTBI is at risk of developing active TB. Screening for, and treating people with, LTBI is an important part of preventi…
I Izanna, S Mohamad Ikhsan, M Mariam, I Siti Hasmah
**INTRODUCTION:** Measles remains a persistent public health concern in Malaysia. Despite sustained high vaccination coverage in states such as Selangor, reported cases continue to increase. This trend suggests a possible shifting age-distribution of measles, a pattern that has b…
I Izanna, S Mohamad Ikhsan, M Mariam, I Siti Hasmah
INTRODUCTION: Measles remains a persistent public health concern in Malaysia. Despite sustained high vaccination coverage in states such as Selangor, reported cases continue to increase. This trend suggests a possible shifting age-distribution of measles, a pattern that has been …
Unki P, Kondekar S, Morkhade K, Rathi SP, Rathi PM
…es start from basic health education and vaccination. Newer vaccines are under trial to improve the efficacy of TB vaccination and yet to be used for general practice. Prevention and immunization against TB have been modified in immunocompromised children. The concept of drug res…
National Institute of Allergy and Infectious Diseases (NIAID)
The purpose of this research is to further study the tuberculosis (TB) vaccine, Bacillus Calmette Guérin (BCG). The goal of this study is to evaluate whether the BCG vaccine is more effective in preventing TB in adults if it is given after 6 months of treatment with a widely used…
Villanueva P, Crawford NW, Croda MG, Croda J, Dalcolmo M, et al.
An accelerated local injection site reaction following Bacille Calmette-Guérin (BCG) vaccination has been associated with underlying active tuberculosis (TB) in high TB-prevalence settings. The clinical significance of this accelerated BCG reaction in individuals without TB sympt…
Martin C, Muls V, Brasseur C, Meric de Bellefon L, Lam Hoai XL, et al.
…1 (96%) patients needed at least one vaccine (a mean of 3.3 vaccines per patient). Live attenuated vaccine was indicated for 45 patients (10%), requiring them to reduce or interrupt their immunosuppressive drug(s). Ninety-two patients (21%) were treated for latent tuberculosis in…
Abdul Razzaq Malik
Every year on 24 March, World Tuberculosis Day is commemorated annually, for raising the public awareness regarding devastating consequences of tuberculosison health and economic aspects of life. This helps to launch efforts to end the globalepidemic of tuberculosis. On the date …
Beaugerie L, Rahier JF, Kirchgesner J
…alendars should be updated according to IBD guidelines-live vaccines should be postponed for patients receiving immunosuppressive drugs. Opportunistic infections should be detected and the vaccine against pneumococcus should be given before patients begin immunosuppressive therap…
Ferenc Karpati, MD, PhD
CF patients are at risk for hepatic disease. Vaccination is recommended to all CF patients according to European consensus. The aim of the study is to vaccinate as many patients as possible and to follow up whether immunization has been complete. Initially, healthy volunteers wi…
Lee H, Kim J, Kang YA, Kim DR, Sim B, et al.
Background: It is important to understand the ability to inhibit mycobacterial growth in healthy adults who would have been Bacillus Calmette-Guérin (BCG) vaccinated in childhood as this group will be the potential target population for novel booster TB vaccine trials. In this st…
Shunli Cai, Yuan Xia, Yingchen Zhou, Yangxuan Lin, Xin Guo, et al.
**BACKGROUND:** The tuberculin skin test (TST), widely used for latent tuberculosis infection (LTBI) screening, shows reduced specificity in Bacillus Calmette-Guérin (BCG)-vaccinated individuals due to antigenic cross-reactivity. We aimed to quantify the impact of BCG vaccin…
Hayder Al-Momen, Tareef Fadhil Raham, Aqil Mohammad Daher
BACKGROUND: Coronavirus current pandemic (COVID-19) is the striking subject worldwide hitting countries in an unexplained non-universal pattern. Bacillus Calmette–Guérin (BCG) vaccine was an adopted recent justification depending on its non-specific immune activation properties. …
Ryndak MB, Laal S
…e and intensive attempts to improve upon BCG or develop new vaccines. Two lacunae in our understanding of the Mycobacterium tuberculosis ( M. tb )-host pathogenesis have mitigated the vaccine efforts; the bacterial-host interaction that enables successful establishment of primary…
Khalid FA, Eldirdery MM, El-Gasim ME, Mukhtar MM
Background Tuberculin skin test (TST) is widely used for the assessment of Bacillus Calmette-Guérin (BCG) vaccine efficacy and screening of latent TB infection (LTBI). Poor or no data are available on the reactivity of tuberculin in Kassala State. The aim of the present study was…
Lu P, Wu K, Zhou H, Yu H, Yuan J, et al.
Recent global guidelines recommend Mycobacterium tuberculosis antigen-based skin tests, such as the ESAT6-CFP10 (EC) skin test, as acceptable alternatives to the tuberculin skin test (TST) and the QuantiFERON-TB Gold In-Tube test (QFT). However, the diagnostic value of these test…
Simon Kimuda, Irene Andia Biraro, Ismail Sebina, Moses Egesa, Angela Nalwoga, et al.
Abstract Antigens from Mycobacterium tuberculosis ( M.tb) , have been shown to stimulate human B cell responses to unrelated recall antigens in vitro . However, it is not known whether natural M.tb infection or whether vaccination with the related species, Mycobacterium bovis BCG…
Choi SH, Oh CE, Lee J, Cho YY, Kwon Y, et al.
Background Tuberculosis (TB) exposure in congregate settings related to neonates is a serious medical and social issue. TB exposure happens during the neonatal period, but contact investigations for exposed infants are usually conducted after the neonatal period. Generally, recom…
Koeken VACM, Verrall AJ, Netea MG, Hill PC, van Crevel R
Background Some individuals, even when heavily exposed to an infectious tuberculosis patient, develop neither active nor latent tuberculosis infection (LTBI). This 'early clearance' of Mycobacterium tuberculosis is associated with a history of bacillus Calmette-Guérin (BCG) vacci…