Showing 151–175 of 200 documents
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Swindells S, Ramchandani R, Gupta A, Benson CA, Leon-Cruz J, et al.
…IV) infection. Preventive therapy is effective, but current regimens are limited by poor implementation and low completion rates. Methods We conducted a randomized, open-label, phase 3 noninferiority trial comparing the efficacy and safety of a 1-month regimen of daily rifapentin…
Sara H Bares, Susan Swindells
…ncreased worldwide, uptake and completion of LTBI treatment regimens among people living with HIV (PWH) are very poor. Concomitant TB-preventive therapy and ART are complex because of drug–drug interactions, but these can be managed. Recent clinical trials of shorter preventive r…
Jaswal M, Farooq S, Madhani F, Noorani S, Salahuddin N, et al.
…l ages were more likely to complete TPT with shorter weekly regimens, although treatment uptake rate for the two regimens was similar.
Jo KW, Kim JS, Kwon HS, Park YE, Kim JY, et al.
Purpose We investigated the adverse events (AEs) and treatment completion rates of a 3 month course of once-weekly isoniazid and rifapentine (3H 1 P 1 ) in South Korean health care workers (HCWs) with latent tuberculosis infection (LTBI). Methods HCWs who were candidates for LTBI…
Tersigni C, Venturini E, Cordola C, Piccini P, Bianchi L, et al.
…d and rifampicin for three or four months are the most used regimens for treating latent tuberculosis. The main aim of this retrospective study is to evaluate the safety of latent tuberculosis treatment by analysing side effects in both regimens. Research design and methods Child…
Tobin EH, Tristram D
… to enhance diagnostic accuracy are gradually emerging. The regimens required to treat TB are challenging to administer. The most commonly used anti-TB antibiotics were developed in the mid-20th century and remain the mainstay of therapy. For the first time in over 40 years, 2 ne…
Borges MASB, Cunha ID, Candini LH, de Souza VA, da Costa PSS
Detailed information concerning latent tuberculosis infection (LTBI) and treatment outcomes is scarce in Brazil. This retrospective cross-sectional study aimed to describe LTB treatment (LTBT) at a tertiary center in Central-West Brazil from 2017 to 2019. We recommended the use o…
Felix Ehret, Fatma Ben Abid, Victor Teatini Ribeiro, Roddy Bodden, Feres Camargo Maluf, et al.
…nerstones used to prevent the activation of TB. The current regimens are lengthy, associated with poor treatment adherence and several side effects. The need for shorter regimens is essential to control TB infection and accomplish the “End TB Strategy,” which has been proclaimed …
Harwood-Johnson E, Leis KS, Hanson J, Olfert J, Blonde Y, et al.
… facilitators, which, in combination with shorter treatment regimens, offer a path forward for LTBI management among refugees resettling in low-incidence countries.
Schein YL, Madebo T, Andersen HE, Arnesen TM, Dyrhol-Riise AM, et al.
… completion did not differ significantly between prescribed regimens (p = 0.124). Adverse events were the most common reason for incomplete treatment. We found no significant differences in adverse events when comparing weekly rifapentine (3RPH) with three months daily isoniazid …
Schmit KM, Lobato MN, Lang SG, Wheeler S, Kendig NE, et al.
…and can be considered a viable alternative to standard LTBI regimens.
Chang YS, Li SY, Pertinez H, Betoudji F, Lee J, et al.
…injectable (LAI) drug formulations may simplify and shorten regimens for this indication. Rifapentine and rifabutin have antituberculosis activity and physiochemical properties suitable for LAI formulation, but there are limited data available for determining the target exposure …
ASST Fatebenefratelli Sacco
…ctable and can lead to treatment interruptions, alternative regimens, or incomplete therapy. Despite the widespread use of INH, real-world data describing the incidence, clinical characteristics, and management strategies of INH-induced hepatotoxicity remain limited, especially i…
Vicky Chang, Greg J. Fox
<b>Background:</b> In Australia, the population at greatest risk of tuberculosis is migrants from high-prevalence countries, among whom TB infection (TBI) is common. The most frequently used treatments for TBI in Australia are six to nine months of daily isoniazid (6-9H) or 4 mon…
Kamolchanok Tanchotikul, Tuntanut Lohawatcharagul, Kamonwan Jutivorakool, Udomsak Bunworasate, Jakapat Vanichanan
Abstract Background Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis following reactivation from latent infection. Immunocompromised individuals, including hematopoietic stem cell transplant (HSCT) recipient, are at risk for active TB which can lead…
Xin Zhang, Ruixia Zhao, Yao Qi, Xiong Yan, Gaoxiu Qi, et al.
(Mtb) infection, Mtb can infect almost all organs of the body and is one of the deadly infectious diseases in the world. At present, the first-line treatment regimen has a long treatment cycle and is prone to multiple drug resistance. Anti-tuberculosis drugs and latent tuberculos…
Z Wang, W J Wang, X Y Ding, P Lu, Limei Zhu, et al.
Tuberculosis (TB) prophylactic therapy for latent infection, which can reduce the risk for the development of active TB, is an important measure in TB control. China recommends prophylactic therapy for latent tuberculosis infection (LTBI) in some key populations to reduce the ris…
Beuy Joob, Viroj Wiwanitkit
Background Tuberculosis is an important infection and is still the most important problem worldwide. The prevention of infection is an important consideration. Focusing on the risk group, HIV-infected patient group is an important risk population for getting tuberculosis. The use…
Senait Cherie Adegeh, Essey Kebede
Objectives: This study focused on modeling of the survival of tuberculosis infected HIV patients treated with antiretroviral treatment in Felege Hiwot referral hospital. Methods: Human Immunodeficiency Virus/tuberculosis (HIV/TB) co-infected patients aged 15 years and above were …
Samuelk Paul
…y burden as well as more durable pharmacologic prophylactic regimens are needed. The broad use of molecular technology and the rapid assessment for drug resistance using nucleic acid amplification testing has greatly enhanced the diagnosis of smear-positive and smear-negative TB.…
Zhang H, Zeng J, Zhu T, Lin T, Song T
Background Tuberculosis (TB) is a major and severe opportunistic infection among solid organ transplant recipients. Chemoprophylaxis is advised for those with latent tuberculosis infection. However, the effectiveness of an isoniazid (INH) prophylactic approach based on TB risk fa…
Sibhat MM, Mulugeta TN, Aklilu DW
Background With expanding access to pediatric antiretroviral therapy, several patients in the developing world were switched to the second-line regimen, and some require third-line medications. A delay in a second-line switch is associated with an increased risk of mortality and …
Cameron LH, Cruz AT
…e administration of shorter, rifamycin-containing treatment regimens. Advancements in the diagnosis and treatment of tuberculosis in children include: use of interferon gamma release assays (IGRAs); molecular-based tests; and shorter courses of treatment. While the essential step…
Furin J, Cox H, Pai M
…dies have shown that shorter latent tuberculosis prevention regimens containing rifampicin or rifapentine are as effective as longer, isoniazid-based regimens, and there is a promising vaccine candidate to prevent the progression of infection to the disease. But new tools alone a…
Delia Goletti, Seif Al-Abri, Giovanni Battista Migliori, Cecilia S. Lindestam Arlehamn, Pranabashis Haldar, et al.
…s to available WHO-recommended TB diagnostics and treatment regimens remains a major challenge, especially in low- and middle-income countries, where 80% of the annual TB caseload occurs. The United Nations General Assembly (UNGA) convened its second High-Level Meeting (HLM) on t…