Showing 151–175 of 200 documents
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Margaret C Siu, Maria Selinopoulou, Susan Abarca Salazar, Jonathan P Sturgeon, Julie Huynh, et al.
…systematic review evaluates their diagnostic performance in pediatric EPTB. **METHODS:** We systematically reviewed host-based gene expression diagnostics for pediatric EPTB. PubMed, Embase and Cochrane Library (January 1965-May 2025) were searched for studies in children (0-18 …
Kaur H, Guglani V, Singhal L, Randev S, Kumar P, et al.
Background Microbiological diagnosis of pediatric tuberculosis (TB) using conventional microbiological techniques has been challenging due to paucibacillary nature of the disease. Molecular methods using cartridge-based tests like Xpert, have immensely improved diagnosis. A novel…
Ganesh Kumar Verma, Muniba Alim, Ramesh Chand, Vinay Verma, Himanshu Gupta
…nd neuroimaging modalities in clinically suspected cases of pediatric TBM and classify cases according to the established diagnostic criteria. MATERIALS AND METHODS: A prospective observational study was conducted at the department of pediatrics of a rural tertiary care center in…
Magni R, Rruga F, Alsaab FM, Sharif S, Howard M, et al.
…nts. In this study we evaluate urinary LAM in HIV negative, pediatric and adult, pulmonary and extrapulmonary tuberculosis patients. We measured 430 microbiologically confirmed pretreatment tuberculosis patients and controls from Peru, Guinea Bissau, Venezuela, Uganda and the Uni…
Manohar Bhatia, Yogesh Sharma, Vikas Dwivedi, Pradeep Sukla, Bikramjeet Mitra, et al.
…cal significance. **RESULTS:** In Datia, the proportion of pediatric TB cases decreased from 6% to 3% (p = 0.04), while extrapulmonary TB (EPTB) cases rose from 11.3% to 13.8% (p = 0.02). Notifications from the private sector significantly increased from 4% to 28% (p = 0.03), wh…
Susanna Esposito, Valentina Fainardi, Beatrice Rita Campana, Gaia Giorgia Arnesano, Nicola Principi
…mong children worldwide, with approximately one million new pediatric cases annually. The conventional treatment for drug-susceptible TB has long relied on a 6-month multidrug regimen, which is highly effective but associated with challenges in adherence, toxicity, and healthcare…
Brigita Ficellia Maria Mahieu, Putu Vivi Paryati
…d to delayed diagnosis. Objective: To report a rare case of pediatric osteoarticular tuberculosis involving the left dorsal foot that initially mimicked malignancy and highlight the importance of clinical suspicion and histopathological confirmation. Case: A 6-year-old boy presen…
Brigita Ficellia Maria Mahieu, Putu Vivi Paryati
…d to delayed diagnosis. Objective: To report a rare case of pediatric osteoarticular tuberculosis involving the left dorsal foot that initially mimicked malignancy and highlight the importance of clinical suspicion and histopathological confirmation. Case: A 6-year-old boy presen…
Peng X, Wang X, Liu Y, Yang H, Yang H, et al.
… investigate the epidemiological profile and cost burden of pediatric inpatients with tuberculous meningitis (TBM) in China. Methods We conducted a descriptive multicenter study involving pediatric TBM inpatients from 9 provincial hospitals and 20 municipal hospitals across 24 pr…
Singh S, Chegondi M, Chacham S, Kumar P, Goyal JP
Background Pediatric tuberculosis (TB) is an indicator of the recent transmission of TB in the community. However, the diagnosis of pediatric TB poses a challenge to clinicians. Aims We aimed to evaluate and compare the clinical and laboratory profile of pulmonary TB (PTB) and ex…
Claudia L. Do Vale, Saraladevi Naicker, Christopher K. Lippincott
… particularly in Africa. Five previous cases, 4 adult and 1 pediatric case, have been published, all from low HIV-TB coinfection settings.8Izzedine H. Brocheriou I. Martinez V. Deray G. Immune reconstitution inflammatory syndrome and acute granulomatous interstitial nephritis.AID…
Lancella L, Abate L, Cursi L, Chiopris G, Nicoletti L, et al.
… to indicate that it accounts for approximately 1-3% of all pediatric TB cases and for no more than 10% of those with extrapulmonary manifestations. It seems, however, that abdominal TB is significantly more common than usually thought as signs and symptoms are non-specific and m…
Sabine Bélard, Charlotte C. Heuvelings, Tom Heller, Savvas Andronikou, Martin P. Grobusch, et al.
…nsenso et al1 report lung ultrasound and CT findings from 9 pediatric TB cases from Sierra Leone (whether these cases had confirmed or unconfirmed PTB is not reported) and conclude that lung POCUS has limitations. We do not share their skepticism with regard to ultrasound for PTB…
Helen E. Jenkins, Jeffrey R. Starke
… disease is both important and challenging.In this issue of Pediatrics, Robsky et al5 present the findings from a systematic review of active case finding (ACF) efforts other than contact tracing to identify children with TB disease. They focus on the measure of “number needed to…
Luh Indrasuari, Sang Ayu Kompiyang Indriyani
…ly she had loss of consciousness and seizures in the way to pediatric ward. After being managed and stabilized, we decided do head CT scan with contrast and found multiple rim enhancing lesions, with a smooth inner outer layer. Mycobacterium Tuberculosis was detected without rifa…
Akshay Kamle, Nilesh Jain, Pramila Ramawat, Hemant Jain
…B) is a leading cause of morbidity and mortality worldwide. Pediatric patients are underdiagnosed and underreported, have a signicantly high mortality risk. CBNAAT is a good diagnostic method to detect mycobacterium tubercule bacilli (MTB). Material and methods: A Prospective ob…
Mohd Jaish Siddiqui, Abhishek Karmacharya, Xuemeng Wan, Yu Zhu, Chaomin Wan, et al.
…dies published between 1900 and 2024. Eligible studies were pediatric case series that included confirmed ATB cases and provided information on initial misdiagnosis or diagnostic delays. Patients who were misdiagnosed or delayed in diagnosis were categorized under the "misdiagnos…
Alabaz D, Çay Ü
…hildren needs increasing attention by physicians caring for pediatric patients. Tuberculous meningitis (TBM) is the most serious form of extrapulmonary tuberculosis that is associated with significant morbidity and mortality rate in the pediatric age group, especially in infants.…
О. К. Киселевич, E.Yu. Radzig, Elena Vlasova, M. G. Kobulashvili, A. V. Abramchenko, et al.
…lem of “extrapulmonary tuberculosis” of ENT localization in pediatric practice, this study analyzes the case histories of 496 patients of tuberculous pulmonary pediatric department No. 1 of the Moscow Research and Clinical Center for Tuberculosis Control. Tuberculous lesion of EN…
Deena Yousif, Sindhu Mohandas, Sally L. Davidson Ward, Ronen Zipkin
Disseminated tuberculosis (TB) in the pediatric population is relatively rare in the United States with variable nonspecific presentations. In this letter we discuss the case of 2-year-old child with a lung mass and central neurogenic hyperventilation with primary respiratory alk…
M Abd Almhmoid Sidiq, Citra Yulia Sari, Selia Cahyani
Background: Urinary retention in pediatric meningitis, particularly tuberculous meningitis (TBM), is an exceptionally rare clinical manifestation. In resource-constrained environments, confirmatory diagnostic procedures such as bone marrow aspiration and culture are often inacces…
Lazarte-Rantes C, Sinti-Ycochea M, Guillen-Pinto D
…althcare professionals. Ultimately, raising awareness among pediatric radiologists, pediatricians, and pediatric neurologists is crucial for prompt intervention and improved outcomes in cases of CNS-TB.
Moretó-Planas L, Mahajan R, Fidelle Nyikayo L, Ajack YBP, Tut Chol B, et al.
…th Organization recommends the Xpert-Ultra assay as a first pediatric diagnosis test, but microbiological confirmation remains low. We aimed to determine the diagnostic performance of Xpert-Ultra with stool and urine samples in presumptive pediatric tuberculosis cases in 2 high-t…
Daya Lal Solanki, Anil Jain, Pukhraj Garg, B. S. Karnawat, Jaiprakash Narayan
…s of TB in adults, but its application for the diagnosis of pediatric TB is under evaluation. Objective: This study was conducted by for cerebrospinal fluid (CSF) examination in the detection of MTB by the culture and sensitivity and CBNAAT in the diagnosis of childhood CNS TB. M…
Radtke KK, Svensson EM, van der Laan LE, Hesseling AC, Savic RM, et al.
…ing rifampicin research that has important implications for pediatric TB treatment and outstanding questions about its pharmacokinetics and optimal dose in children. Areas covered This review aims to summarize and discuss emerging data on the use of rifampicin for: 1) routine tre…