Showing 151–175 of 200 documents
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Matsui T, Pinhata JMW, Rabello MCDS, Brandão AP, Ferrazoli L, et al.
BACKGROUND Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, and the number of new cases of multidrug resistant TB (MDR-TB), pre extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB) has increased consid…
Kaniga K, Hasan R, Jou R, Vasiliauskienė E, Chuchottaworn C, et al.
Bedaquiline Drug Resistance Emergence Assessment in Multidrug-resistant tuberculosis (MDR-TB) (DREAM) was a 5-year (2015 to 2019) phenotypic drug resistance surveillance study across 11 countries. DREAM assessed the susceptibility of 5,036 MDR-TB isolates of bedaquiline treatment…
Wilson M, Weston J, Mullen A, Knight T, Simpson G
…e state and national average. Aims To document tuberculosis epidemiology in FNQ compared to two previous audits of the region. Methods Retrospective clinical audit of all cases of tuberculosis reported to the Cairns Tuberculosis Control Unit between 2006 and 2016. Results A total…
Masoud K, Araj GF, Reslan L, Fadlallah S, Wehbe M, et al.
…y is one of the first to describe the genomic diversity and epidemiology of MTB isolates of Lebanon, and suggests an increasing prevalence of SIT127 in the country.
Saravanan M, Niguse S, Abdulkader M, Tsegay E, Hailekiros H, et al.
…. This review describes the disease etiology, pathogenesis, epidemiology, molecular mechanism and advanced molecular diagnostics for precision MDR-TB diagnosis.
Migliori GB, Tiberi S, Tiberi S, Zumla A, Petersen E, et al.
…ce and ATS/CDC/ERS/IDSA guidelines. After a rapid review of epidemiology and risk factors, the clinical priorities on MDR-TB diagnosis (including whole genome sequencing and drug-susceptibility testing interpretations) and treatment (treatment design and management, TB in childre…
Bainomugisa A, Pandey S, Donnan E, Simpson G, Foster J, et al.
In this retrospective study, we used whole-genome sequencing (WGS) to delineate transmission dynamics, characterize drug-resistance markers, and identify risk factors of transmission among Papua New Guinea residents of the Torres Strait Protected Zone (TSPZ) who had tuberculosis …
Chen CY, Weng JY, Huang HH, Yen WC, Tsai YH, et al.
Drug-resistant tuberculosis (TB) is a global crisis and a threat to health security. Since conventional drug susceptibility testing (DST) takes several weeks, we herein described a molecular assay to rapidly identify multidrug-resistant (MDR) and extensively drug-resistant (XDR) …
Perdigão J, Gomes P, Miranda A, Maltez F, Machado D, et al.
Portugal is a low incidence country for tuberculosis (TB) disease. Now figuring among TB low incidence countries, it has since the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predominantly by two strain-types: Lisboa3 and Q1. This stud…
Golli AL, Niţu MF, Turcu F, Popescu M, Ciobanu-Mitrache L, et al.
Background Tuberculosis (TB) remains a major public health problem in Romania, which has the highest TB incidence in the European Union. Methods We undertook a retrospective study to describe changing trends in the main epidemiological indicators of TB in Romania from 1995 to 201…
Zong Z, Jing W, Shi J, Wen S, Zhang T, et al.
Oxazolidinones are efficacious in treating mycobacterial infections, including tuberculosis (TB) caused by drug-resistant Mycobacterium tuberculosis In this study, we compared the in vitro activities and MIC distributions of delpazolid, a novel oxazolidinone, and linezolid agains…
Zunt JR
Purpose of review This article details the epidemiology and clinical manifestations of central nervous system (CNS) tuberculosis (TB), provides guidance for diagnostic imaging and CSF testing, and recommends treatment strategies for tuberculous meningitis and other forms of CNS T…
Mokrousov I, Vyazovaya A, Pasechnik O, Gerasimova A, Dymova M, et al.
Objective The Mycobacterium tuberculosis Beijing family is an epidemiologically important lineage subdivided into large-scale phylogenetic sublineages: ancient, endemic in East Asia, and global modern. Here, we analysed ancient sublineages of the Beijing genotype in the Omsk regi…
Roa MB, Tablizo FA, Morado EKD, Cunanan LF, Uy IDC, et al.
Objectives Thousands of cases of multidrug-resistant tuberculosis (TB) have been observed in the Philippines, but studies on the Mycobacterium tuberculosis (MTB) genotypes that underlie the observed drug resistance profiles are lacking. This study aimed to analyse the whole genom…
Yu X, Zeng X, Shi W, Hu Y, Nie W, et al.
Cycloserine (Cs) is recommended by the World Health Organization as a second-line drug to treat multidrug-resistant tuberculosis (MDR-TB); however, its efficacy has never been sufficiently evaluated. To gain some insights into the value of cycloserine for MDR-TB treatment, in vit…
Oh JY, Park KH, Lee J, Kim D, Seok KH, et al.
Whole-genome sequencing (WGS) is promising for the quality control of laboratory facilities for Mycobacterium tuberculosis (MTB) strains. We describe the clinical and laboratory characteristics of false positive versus true positive MTB cultures based on WGS, which were experienc…
Phelan JE, O'Sullivan DM, Machado D, Ramos J, Oppong YEA, et al.
Background Mycobacterium tuberculosis resistance to anti-tuberculosis drugs is a major threat to global public health. Whole genome sequencing (WGS) is rapidly gaining traction as a diagnostic tool for clinical tuberculosis settings. To support this informatically, previous work …
Bhandari J, Thada PK, Hashmi MF, DeVos E
…have decreased the disease burden. This activity covers the epidemiology, pathophysiology, treatment, management, complications, patient education, prevention measures, and the role of the interprofessional team in improving patient care and decreasing the burden of this disease.…
Porgo TV, Norris SL, Salanti G, Johnson LF, Simpson JA, et al.
Mathematical modeling studies are increasingly recognised as an important tool for evidence synthesis and to inform clinical and public health decision-making, particularly when data from systematic reviews of primary studies do not adequately answer a research question. However,…
Antonino Catanzaro, MD
The goal of this study is to evaluate time to diagnosis for three assays (line probe, pyrosequencing, and Microscopic Observation Drug Susceptibility Assay \[MODS\]) to detect resistance to first and second-line anti-tuberculosis (TB) drugs in Mycobacterium tuberculosis (Mtb) str…
National University Hospital, Singapore
…, gaming arcades and even housing estates. Global and local epidemiology indicates that TB remains an infectious disease threat. One of the most severe forms of TB is CNS-TB which can lead to significant morbidity and mortality. In CNS-TB, tissue destruction can result in long-t…
Beijing Hospital
Background: Drug resistant tuberculosis is a serious public health problem that threatens the health of human life and the development of society and economy. At present, the diagnosis of drug-resistant tuberculosis mainly depends on traditional drug susceptibility test. But it …
Xavier ARGEMI, MD
The purpose of this study is to examine the epidemiology of TB MR in Strasbourg and evaluate the second-line anti-tuberculosis treatments effectiveness, and the relevance and adequacy of the treatments with WHO recommendations. During years 2006-2016, all new cases of MDR TB or X…
Clifton E Barry, Ph.D.
Background: \- In spite of well-researched treatments and therapies, 5 to 10 percent of tuberculosis (TB) patients who have initially successful TB treatments will relapse, usually within a year after completion of therapy. This percentage is even greater for patients who are in…
Nawal Salahuddin, MBBS,FCCP
Tuberculosis is a global public health problem. One third of the world's population is infected with tuberculosis (TB) with almost 2 million deaths per year globally. According to the WHO, Pakistan ranks 8th amongst the 22 high TB burden countries, with an estimated prevalence is…