Showing 151–175 of 200 documents
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Jin Mo Goo, M.D.
…renchyma in close contacts at high risk for developing multidrug- or extensively drug-resistant Tb by using a follow-up ultralow dose CT scan. Multidrug- or extensively resistant tuberculosis tuberculosis is a major public health threat worldwide and the global burden of drug-re…
Mandlenkosi Manika, Lindiwe Modest Faye, Ntandazo Dlatu, Mojisola Clara Hosu
Background: The global burden of drug-resistant Mycobacterium tuberculosis continues to threaten tuberculosis control efforts, largely due to the emergence and transmission of resistance-associated genetic mutations. Molecular epidemiology provides critical insights into mutation…
Chirag J Gohil, Ketan C. Parmar, Priyanka R. Patel, Jignakumari J. Gohil
Drug resistance in tuberculosis has been shown to result from spontaneous mutation in several chromosomal genes of M.Tuberculosis. Mutation may reduce the medications' capacity to bind to the target genes. In many patients polydrug resistance, multidrug resistance, rifampicin res…
Salam El Achkar
…, with 10 million new cases estimated worldwide in 2017. TB drug resistance and its diagnosis are particularly problematic. Only 25% of the 450,000 incident multidrug resistant (MDR) TB patients estimated over the same year were diagnosed and treated as such.Although Lebanon is a…
K SP, Parivakkam Mani A, S G, Yadav S
…bal health concern, particularly with the emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB). Traditional methods for diagnosing drug resistance in TB are time-consuming and often lack accuracy, leading to delays in appropr…
Muhammad Arslan, Rohan Arshad, Faizan Hameed, Sidra Iqbal, Ijaz Ahmad, et al.
Background: The rise of drug-resistant tuberculosis (TB) poses a critical challenge to global TB control efforts, with multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB strains complicating treatment outcomes. The fitness cost associated with drug resistance mutat…
Lin M, Zhong Y, Chen Z, Lin C, Pei H, et al.
Objectives To assess the proportion of drug-resistant tuberculosis (TB) cases and to identify independent risk factors associated with drug-resistant TB in Hainan. Methods Descriptive analysis of demographic and clinical data of culture-positive TB patients to assess the trends i…
О.С. Шевченко, L.D. Todoriko, R.S. Shevchenko, S.L. Matvyeyeva, І.А. Овчаренко, et al.
…defensin-1, ferritin and Interleukin-6 and the spectrum of drug resistance, as well as the treatment regimens in patients with pulmonary tuberculosis. Materials and methods. This study included 100 patients with pulmonary tuberculosis, divided into two groups: Group 1 (n = 52) w…
Kasimu Mamuda, Aliyu Sani, Steven Olonitola, Opaluwa Saraja
…tious diseases that cause death worldwide; the emergence of drug resistant mycobacterium tuberculosis is of great concern for TB control programme in Nigeria. Aim and objective: To detect multi-drug and extensively drug resistant mycobacterium tuberculosis among tuberculosis pati…
Sunil Bajeja, Kandula Jayapaul, Poonam Gaur, Chinnem Rama Mohan, Abhinav Pathak, et al.
… problem around the world. This is especially true now that drug-resistant forms of TB like Multi-Drug Resistant (MDR) and Extensively Drug-Resistant (XDR) are becoming more common. Traditional ways of diagnosing drug resistance take a lot of time and resources, which means they …
Jinyun Zhao, Weifang Mao, Faxiang Jin, Wenfang Xu
**OBJECTIVE:** This study aimed to analyze drug resistance patterns, mutation profiles inisolates and clinical characteristics of tuberculosis patients in Shaoxing, Zhejiang, China. **METHODS:** Clinical specimens and data from tuberculosis patients admitted in 2024 were collect…
Yuchuan Zhao, Chenchen Zhang, Xuezhi Wang, Huiying Feng, Meiling Yu, et al.
**UNLABELLED:** The drug-resistant tuberculosis (TB) is a major public health problem worldwide. Capreomycin (Cm) has been used as an effective drug to treat multidrug-resistant tuberculosis (MDR-TB) since 1960s. Although Cm and amikacin (Am) are historically grouped as second-li…
Degiacomi G, Sammartino JC, Sinigiani V, Marra P, Urbani A, et al.
…s one of the major causes of death related to antimicrobial resistance worldwide because of the spread of Mycobacterium tuberculosis multi- and extensively drug resistant (multi-drug resistant (MDR) and extensively drug-resistant (XDR), respectively) clinical isolates. To fight M…
Supriya Dhakne
Introduction: Multidrug‑resistant tuberculosis (MDR‑TB) has created a significant health problem in most of the countries, and it is an obstacle to effective TB control. Aims and Objectives: The study aims to study the prevalence of MDR‑TB among new cases, retreatment cases and t…
Harun Patel, Iqrar Ahmad, Harsha Jadhav, Rahul Pawara, Anand B. Mundada, et al.
…(TB) management remains challenging due to the emergence of drug-resistant tuberculosis such as MDR-TB and XDR-TB. To improvise therapeutic results for MDR/XDR-TB, 89 nations had started utilizing bedaquiline and 54 had utilized delamanid by June 2017. Unfortunately, cardiac arrh…
Mokrousov I, Sinkov V, Vyazovaya A, Pasechnik O, Solovieva N, et al.
…ype characterized by an unexpectedly high rate of extensive drug resistance (XDR). In the current study, next generation sequencing data were analysed to gain insight into genomic signatures underlying drug resistance of these strains. A total of 184 genomes of the Beijing early …
Mongia H, Mamnoon F, Silsarma A, Mahajan R, Dalal A, et al.
…ndividualised regimens for eligible patients with pulmonary drug-resistant tuberculosis (DR-TB); however, data for patients with drug-resistant extrapulmonary tuberculosis (EPTB) is extremely limited. This study documents the treatment outcomes and adverse events associated with …
Justin Ginting, Katharina Ellen Dominika, Ardo Sanjaya, Julia Windi Gunadi
…at causes the infectious disease tuberculosis. Based on its resistance, tuberculosis can be divided into Drug-susceptible Tuberculosis (DS-TB) and Drug-resistant Tuberculosis (DR-TB). MDR-TB is one type of DR-TB when M. tuberculosis complex strains unresponsive to rifampicin and …
Lindiwe Modest Faye, Carine Bokop, Sandeep Vasaikar, Teke Apalata, Ntandazo Dlatu
…he fight against such illnesses has led to the emergence of drug-resistant infectious diseases, which have become increasingly dif-ficult to manage as medical and scientific research has advanced. Inadequate medical infrastruc-ture, incorrect treatment practices that exacerbate r…
Jan F, Wali S, Sadia S, Akbar MT, Akbar HS, et al.
Introduction Multidrug resistant TB (MDR-TB), defined as resistance to at least rifampicin and isoniazid together, has been rapidly spreading in recent years. In new pulmonary tuberculosis patients, rapid spread of MDR-TB and XDR-TB challenging the effectiveness of national TB co…
О.С. Шевченко, О.О. Pohorielova
Background. Multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis remain severe epidemic problems in the world. That’s why the purpose of our study was to investigate the dynamics of the incidence of multidrug-resistant and extensively drug-resistant tuberc…
Nwachukwu NO, Ulasi AE, Okoronkwo CU, Unegbu VN
Background Pre-extensively drug-resistant tuberculosis (Pre-XDR-TB), an emerging form of drug-resistant tuberculosis, is challenging efforts at tuberculosis control, leading to treatment failure among multidrug-resistant tuberculosis (MDR-TB) patients and progression to extensive…
Daoyan Tang, Ba La, Jian-Qing He
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is associated with alterations in drug pharmacokinetics (PK), aberrant expression of efflux pump transporters, and genetic mutations. Polymorphisms in host genes encoding efflux pumps may affect drug concentrations, potentially …
Zuhriyyah SA, Nugraha HG, Setiabudi D, Santoso P, Nataprawira HM
…ate and compare the CXR findings of children with pulmonary drug-resistant TB (DR-TB) and drug-sensitive TB (DS-TB) that could help in the evaluation and management of TB cases in children. Methods Retrospective analysis with cross-sectional approach was conducted in children ( R…
Naoufal Sirri, Christophe Guyeux, Christophe Sola
…ains a significant public health issue, and addressing multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains is a critical global health priority. Resistance primarily results from mutations in genes related to drug targets or enzyme conversions, though our under…