Showing 151–175 of 200 documents
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M. Das, Keka Sarkar
Recently, drug-resistant tuberculosis is of great concern owing to lack of new drugs.Rapid identification of unique drug targets against Mycobacterium tuberculosis DKC2 strain is crucial.In silico subtractive genomics methods identified 230 essential non-homologous proteins.Drugg…
Qi Ren, Yingzhi Chong, Yuhong Li, Tiesheng Han, Mengshi Chen, et al.
To clarify the role of N th gene in drug resistance of Mycobacterium tuberculosis (MTB), the clinical strain MTB were isolated and cultured from the sputum of pulmonary tuberculosis patients, and grouped according to the results of drug sensitivity tests. The expression levels of…
Arora G, Bothra A, Prosser G, Arora K, Sajid A
…, failing of which leads to relapse and/or the emergence of drug resistance. There is a critical need to understand the mechanisms of resistance development. With increasing drug pressure, Mycobacterium tuberculosis (Mtb) activates various pathways to counter drug-related toxicit…
Teresia Talantan Kondolele, Dian Mirza Togubu, Musfirah Achmad
Introduction: Drug-resistant tuberculosis (TB-RO) is still a health problem because of its rapid transmission with an increasing number of cases. Objective: This study aims to discover in-depth patient knowledge about tuberculosis and the family's role in treating drug-resistant …
Mugumbate G, Nyathi B, Zindoga A, Munyuki G
The emergence of drug-resistant strains of Mycobacterium tuberculosis ( Mtb ) impedes the End TB Strategy by the World Health Organization aiming for zero deaths, disease, and suffering at the hands of tuberculosis (TB). Mutations within anti-TB drug targets play a major role in …
Payal P. Naik, Arvind S Pandey, Swati Patel
Background: Drug resistant tuberculosis is an important public health issue in India. The treatment regimen followed is Programmatic Management of Drug resistant Tuberculosis (PMDT) approach. Adverse drug reactions (ADRs) are a serious issue which increases the risk of defaulter …
Massud A, Syed Sulaiman SA, Ahmad N, Shafqat M, Chiau Ming L, et al.
Drug-resistant tuberculosis (DR-TB) management is often linked with a higher rate of adverse drug reactions (ADRs) needing effective and timely management of these ADRs, which, if left untreated, may result in a higher rate of loss to follow-up of drug-resistant patients. Study o…
Moon SM, Lee WY, Shin B
…nary TB, available data on the clinical characteristics and drug susceptibility (DST) patterns of patients with EBTB are scarce. Methods We evaluated the clinical characteristics of patients with EBTB in South Korea and the culture-based DST patterns of EBTB. Further, the DST pat…
Vu Thi Thom, Le Thi Luyen, Lê Anh Tuấn, Pham Thi Hong Nhung, Nguyễn Thị Thu Hà
Drug resistant TB is currently a global challenge causing high risk of death and expanding the disease. This study explores the prevalence of drug resistance in newly diagnosed and recurrent TB patients and identifies the association between NAT2 gene polymorphism distribution an…
Jaya Martolia, Hardik Soni, Falguni Tandel
…llenge. Major problem of long-term use of existing anti -TB drugs are drug resistance and adverse effects. Drug resistant tuberculosis is widespread and is now a threat to tuberculosis control programme in many countries. Natural products derived from medicinal plants may play a …
Shimelis Bekele Zerefe, Temesgen Tibebu Mekonnen
…eproduction number of the dynamical system which experience drug sensitive strain and the effective reproduction number of the dynamical system which experience multi drug resistance strain. Using real data collected from different health sectors from Ethiopia we found that the n…
Anastasia Kazulina, Irina Vasilyevа, Ruslan Khachetlov, L. Parolina, Valentina Tinkova, et al.
To assess of Nontuberculous mycobacteria (NTM) drug resistance as base for further discovery and improvement of mycobacteriosis therapy. NTM are increasing around the world. These mycobacteria, which comprise a large and diverse range of species, have developed resistance to most…
Wiwien Hadikurniawati, Muchamad Taufiq Anwar, Dwi Marlina, Haryo Kusumo
…s. It is known that several strains of MTB are resistant to drugs used in the treatment. This situation calls for the importance to detect and prevent further drug resistance and thus reducing the mortality rate. The conventional molecular diagnostic test is costly, requires a lo…
Nande A, Hill AL
The emergence of drug resistance during antimicrobial therapy is a major global health problem, especially for chronic infections like human immunodeficiency virus, hepatitis B and C, and tuberculosis. Sub-optimal adherence to long-term treatment is an important contributor to re…
Brigitta Derendinger, Anzaan Dippenaar, Margaretha de Vos, Rudi Alberts, Frederick A. Sirgel, et al.
…bjectives: Potentially transformative new tuberculosis (TB) drugs like bedaquiline are undergoing roll-out, however, this is largely in the absence of programmatic drug susceptibility testing (DST). We lack information on how susceptibility changes during treatment in patients on…
Joshi RC, Dereddy HR, Mukhopadhyay S, Burget R, Dutta MK
…ains a major global health concern, especially due to multi-drug resistance. Resistance often arises from single nucleotide mutations in drug-target genes, making early prediction vital for effective treatment. Genomic sequencing enables resistance profiling, but accurate predict…
Rakesh Chandra Joshi, Hitesh Reddy Dereddy, Sandip Mukhopadhyay, Radim Burget, Malay Kishore Dutta
…ains a major global health concern, especially due to multi-drug resistance. Resistance often arises from single nucleotide mutations in drug-target genes, making early prediction vital for effective treatment. Genomic sequencing enables resistance profiling, but accurate predict…
Sahar Ghazanfari, Shahla Roudbar Mohammadi, Sasan Rezaei
…n the expression of interfering genes in susceptibility and drug resistance in these fungi were investigated. Materials and Methods Collecting samples and isolating Candida glabrata (C. glabrata) and Candida albicans (C. albicans) with phenotypic methods were accomplished. In thi…
Shewki Moga, Muluwork Getahun, Zemedu Mohammed, Ayinalem Alemu, Getu Diriba, et al.
**BACKGROUND:** Drug-resistant tuberculosis (DR-TB) is a major challenge hindering global tuberculosis control. Ethiopia conducted a third national antituberculosis (TB) drug resistance survey, and this is the first survey to report on drug resistance using whole genome sequencin…
Ayanwale O Abraham
…udies have been carried out to understand the mechanisms of drug resistance by this organism. An attempt was made in this write up to elucidate the various mechanism of drug resistance in M. tuberculosis, including its innate impermeable cell wall and mutation of specific genes. …
Cong Shen, X X Zhang, C C Bao
…imens and distributed in intensive care department, and the drug resistance characteristics were mainly KPC type in carbapenemase production. Clinical microbiology laboratory should strengthen the monitoring of CRKP strains, so as to provide reference for preventing CRKP infectio…
Mallick JS, Nair P, Abbew ET, Van Deun A, Decroo T
Background Drug-resistant tuberculosis (DR-TB) is considered to be a public health threat and is difficult to cure, requiring a lengthy treatment with potent, potentially toxic drugs. The novel antimicrobial agent bedaquiline has shown promising results for patients with DR-TB, i…
Vats S, Shanker A
Drug resistance has been associated with point mutations in coding regions leading to an altered protein sequence and structure. Such changes have been seen as isolated events occurring at various positions in a sequence. However, we hypothesise that it is not a single mutation a…
Paola Corona, Roberta Ibba, Sandra Piras, Paola Molicotti, Alessandra Bua, et al.
…as M. simiae and M. abscessus. The two NTMs were tested for drug susceptibility against different antibiotics. To restore drug susceptibility, a new series of 2-aryl-3-phenoxymethyl-quinoxaline derivatives (QXs) was designed, synthesized, and investigated as efflux pump inhibitor…
Pinto D, Dhawale A, Shah I, Rokade S, Shah A, et al.
Background context The emergence of drug resistance has complicated the management of spinal tuberculosis (TB). While it is well known that the medical management of drug-resistant spinal TB is more difficult, the surgical outcomes of the same have not been studied sufficiently, …