Showing 151–175 of 200 documents
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Brooke E Nichols, Alexandra de Nooy, Naseem Cassim, Lucia Hans, Manuel Pedro da Silva, et al.
ABSTRACT To ensure there is adequate investment into diagnostics, an understanding of the magnitude of impact and return on investment is necessary. We therefore sought to understand the health and economic impacts of the molecular diagnostic programme in South Africa, to deepen …
Jean de Dieu Iragena, Achilles Katamba, Anandi Martin, Moses Joloba, Willy Ssengooba
…CT Background The implementation of rapid tuberculosis (TB) diagnostics is essential for TB control. Factors influencing their uptake in Africa are unknown. We conducted a survey to collect the status and document Predisposing, Enabling, and Need (PEN) factors influencing so that…
All India Institute of Medical Sciences
The goal of this Diagnostic accuracy study is * To study sensitivity and specificity of sulcal tuberculomas in the diagnosis of tubercular meningitis and * To study the correlation of imaging findings in tubercular meningitis and spinal tubercular arachnoiditis with clinical out…
Justin Onyebuchi Nwofe, Laura Madukaji, Daniel Chinenyeike Offie, Dickson Adeolu Adetoye, Emmanuel Adewale Ojo, et al.
Abstract Introduction Tuberculosis (TB) diagnosis remains the weakest link in the care cascade, particularly among people living with HIV and AIDS (PLHIV) with advanced HIV disease (AHD), who are often cannot produce quality sputum for standard tests. Urine-based assays such as D…
Du J, Shu W, Liu Y, Wang Y, Zhan Y, et al.
…l external quality assessment (EQA) panels for molecular TB diagnostics. In addition, we also assessed the performance of the laboratories with the EQA panels in China. Dried Mycobacterium tuberculosis (MTB) DNA in the chelex resin was designed as part of an EQA program. The stor…
A. de Nooy
…agnostic care cascade. In many contexts, access to accurate diagnostics can be limited or delayed, with this contributing to onwards transmission and poorer health outcomes. Substantial investment in the research, development, and implementation of affordable, scalable, and conte…
Harriet N. Garlant, Kalaiarasan Ellappan, Noyal Mariya Joseph, Carrie Turner, Vishnukanth Govindaraj, et al.
…et Product Profiles (TPPs) call for rapid, non-sputum-based diagnostics with high sensitivity and specificity. This study evaluates our previously published TB-associated host-immune biomarkers alongside small-size signatures from other studies, in our previously published non-hu…
Tandel N, Joseph AZ, Joshi A, Shrama P, Mishra RP, et al.
…formulation and their utilization in the field of molecular diagnostics for TB. The review also sheds a light on other nanoparticle-based molecular diagnostic approaches for TB. Despite the advent of science, we are yet to have a diagnostic tool that is simple, rapid, sensitive, …
Christoph Lange, Professor
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investig…
Lucy Mupfumi, Tapson Nyondo, Judith Mzyece, V. Kampira, Moussa Condé, et al.
…ators to reaching universal access to WHO-recommended rapid diagnostics (WRDs) in a selection of African countries. Data for 24 African countries were sourced from the WHO Global TB database to evaluate the proportion of notified people with TB tested with a WRD between 2021 and …
Xiaoting Liu, Dong XiLin, Yu Zhang, Ping Fang, Hongyang Shi, et al.
Abstract Background: Pleural effusions are caused by various reasons, whose diagnosis remains challenging in spite of various means of diagnosis. Medical thoracoscopy, greatly improves the diagnostic efficacy and gets preference for managements, especially undiagnosed pleural eff…
Muhammad Nusrullah, Afeera Hamid, Muhammad Rashid, Hafiz Muhammad Taha Waqas, Abdul Rauf
Fiberoptic bronchoscopy with bronchial washing is done for diagnosis of pulmonary tuberculosis among patients who cannot produce sputum spontaneously. Aim: To evaluate the diagnostic yield of Fiberoptic Bronchoscopy for detection of positive cases in cases of Smear negative pulmo…
Olivier Marcy, PhD, Maryline Bonnet, PhD, Eric Wobudeya, PhD
The TB-Speed Decentralisation study aims to increase childhood Tuberculosis (TB) case detection at district hospital (DH) and Primary health Care (PHC) levels using adapted and child-friendly specimen collection methods, i.e. Nasopharyngeal Aspirate (NPA) and stool samples, sensi…
Eduarda Rabello, Fernanda de-Paris
Tuberculosis (TB) remains one of the leading causes of death from a single infectious agent worldwide, a burden further exacerbated by HIV co-infection and the increasing prevalence of drug-resistant strains. Although a wide range of laboratory diagnostic methods are currently av…
Olivier Marcy, MD, PhD, Maryline Bonnet, MD, PhD, Eric Wobudeya, MD, PhD
TB-Speed SAM is a multicentric, prospective diagnostic cohort study conducted in two countries with high and very high TB incidence (Uganda and Zambia). It aims at assessing several diagnostic tests that could result in the development of a score and algorithm for TB treatment de…
Saini S, Prasad BM, Mahajan A, Duhan A, Jangra A, et al.
…from implementation indicate the need to strengthen private diagnostics through a certification process to ensure provision of quality TB diagnostic services.
Hamid Dahmardeh, Alireza Teimouri, Zeynab Shayan Khah
Background: Pulmonary tuberculosis (PTB) remains a major global health concern that requires early and accurate diagnosis. Standard methods, such as sputum smear microscopy and culture, are often slow and may miss smear-negative cases. Chest computed tomography (CT) can reveal ra…
Peerzada Ajaz A Shah, Mustafa Bashir, Moien Farooq, Tavseef A Tali, Toufeeq A Teli
**BACKGROUND:** Exudative pleural effusion is a common clinical problem with diverse etiologies, often requiring invasive procedures for definitive diagnosis. While conventional cytology is widely used, its diagnostic yield remains limited. Ancillary methods such as cell block (C…
Xie L, Zhu G, Long S, Wang M, Cheng X, et al.
Background Current diagnostic methods cannot effectively distinguish between latent tuberculosis infection (LTBI) and active tuberculosis (ATB). This study aims to explore novel non-invasive diagnostic biomarkers for LTBI and to elucidate possible molecular mechanisms of LTBI pat…
Li Y, Luo D, Zheng Y, Liu K, Chen S, et al.
Objective To understand and analyze the factors relating to patient and diagnostic delays among groups with tuberculous pleurisy (TP), and its spatiotemporal distribution in Zhejiang Province. Methods Data of all tuberculous pleurisy patients were collected from the existing Tube…
MH Mezzour, M. Karhate, L. Senhaji, M. Taghyioullah, B. Amara, et al.
Abstract RATIONALE: Pseudotumoral tuberculosis (TB), an uncommon malignancy-mimicking form of pulmonary TB, often causes diagnostic delays, especially in patients without TB history or immunosuppression. In TB-endemic areas, reliance on negative sputum culture or GeneXpert result…
Khambati N, Song R, MacLean EL, Kohli M, Olbrich L, et al.
Background Tuberculosis (TB) is a leading cause of death in children, but many cases are never diagnosed. Microbiological diagnosis of pulmonary TB is challenging in young children who cannot spontaneously expectorate sputum. Nasopharyngeal aspirates (NPA) may be more easily coll…
І. В. Ліскіна, С. Д. Кузовкова, Л. М. Загаба, О.D. Nikolaeva
… diagnosed in 13 % of cases. The main methods of laboratory diagnostics were classical bacteriological methods — simple direct light microscopy and MBT culture, the positive results of which were obtained in only half of all studies, as well as molecular-genotypic tests. Prevalen…
Lucy Mupfumi, Tapson Nyondo, Judith Mzyece, Vincent Kampira, Moussa Condé, et al.
…eaching universal access to WHO-recommended rapid molecular diagnostics (WRDs) in a selection of African countries. Data for 24 African countries were sourced from the WHO Global TB database to evaluate the proportion of notified people with TB tested with a WRD between 2018 and …
Lehman A, Ellis J, Nalintya E, Bahr NC, Loyse A, et al.
…ve of this review is to highlight novel point-of-care (POC) diagnostics and treatment strategies that can facilitate OI screening and prophylaxis for persons with AHD. Methods We reviewed the WHO guidelines for recommendations for persons with AHD. We summarized the scientific li…