Showing 151–175 of 200 documents
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Christine Ho, MD, Dolly Katz, PhD, Thara Venkatappa, PhD
… is a prospective cohort study of persons tested for latent tuberculosis infection at either high risk for exposure to Mycobacterium tuberculosis or high risk for progression to tuberculosis disease. The study will assess the relative performance and cost of three diagnostic test…
S Praveen Raj Dr. Anitha S Menon
…cemasks is likely to reduce the spread of <em>Mycobacterium tuberculosis (MTB)</em>. However, there is an anticipated net negative effect of COVID-19 on TB control, including an increase in the number of TB cases, death and the proportion of drug- resistant TB. Here, we present s…
Smith A, Kempker R, Wassie L, Bobosha K, Nizam A, et al.
…amines the association between diabetes mellitus and latent tuberculosis infection among a cohort of household contacts exposed to active tuberculosis in Ethiopia, focusing attention on the need for further translational research to determine the mechanisms of susceptibility to M…
Liu Y, Zhang L, Chen Y, Ruan G, Liu Y, et al.
Background The population with latent tuberculosis infection (LTBI) represents a potential pool of patients with active tuberculosis (ATB). T-SPOT.TB is an important test tool for screening LTBI. Owing to the large population of LTBI patients in China, it is necessary to identify…
Justen T Despain, John L Kiley, Mary B Ford
**INTRODUCTION:** Tuberculosis (TB) causes significant morbidity and mortality worldwide. Diagnosing TB in service members can be a challenge given the overall low incidence but increased risk of exposure that accompanies military travel, training and activities. Here we describe…
Luo D, Yang BY, Qin K, Shi CY, Wei NS, et al.
Purpose Distinguishing latent tuberculosis infection (LTBI) from active tuberculosis (ATB) is important to control the prevalence of tuberculosis; however, there is currently no effective method. The aim of this study was to discover specific metabolites through fecal untargeted …
Lee JY, Kim BJ, Koo HK, Kim J, Kim JM, et al.
Tuberculosis remains a major public health problem. Conventional tests are inadequate to distinguish between active tuberculosis (ATB) and latent tuberculosis infection (LTBI). We measured antibody responses to Mycobacterium tuberculosis antigens ( Mycobacterium tuberculosis chor…
Tang W, Leonhardt L, Pervez A, Sarvepalli S
The reactivation of latent tuberculosis occurs when a patient living with Mycobacterium tuberculosis enters a state where the immune system is suppressed. Since early 2021, the standard of care has been to provide corticosteroids in patients with COVID-19 infection in hospitalize…
M. A. Vladimirskiy, M. B. Lapenkova, A. A. Elov, В. А. Аксенова, М. А. Плеханова, et al.
…led in the study, of them 8 children suffered from pulmonary tuberculosis (TB Group) and 91 had LTBI (LTBI Group). Detection of subclinical signs of tuberculosis infection activity in LTBI Group included testing the concentration of antigen-specific induction of IFN-γ at the level …
Azadeh Jafrasteh, Abdollah Karimi, Seyedeh Mahsan Hoseini‐Alfatemi, Leila Azimi, Payam Tabarsi, et al.
…are the most important diagnostic approach to Mycobacterium tuberculosis infection diagnosis. However, they cannot discriminate between latent tuberculosis infection (LTBI) and active tuberculosis (TB). Some recent studies suggested that interleukin-2 (IL-2) response to M. tuberc…
Jeffrey M. Singh, Lamiya Balushi, Nada Mahrazi, Esklid Peterson, Olivier Koole, et al.
…ackground: Oman is a high-income, low prevalent country for tuberculosis disease. Although the rates have remained static over the last decade, the country is aiming for Tuberculosis (TB) elimination. Household contacts of pulmonary TB (PTB) patients form a high-risk group of sus…
Rosana Agus, Sjafaraenan, Yulianti Samara, Muhammad Nasrum Massi
The main challenge in the management of Tuberculosis (TB) is diagnosing quickly and accurately, especially Latent Tuberculosis Infection (LTBI). LTBI detection was carried out using the Tuberculin Skin Test (TST) and Interferon Gamma Release Assay (IGRA). In TB endemic areas, the…
Paola Dal Monte, MD
In the last 30 years, tuberculosis (TB) has re-emerged in industrialised countries as a public health, with a decrease in incidence among the resident population and an increase in the burden of immigrants. Therefore, it becomes a priority to implement an effective TB control tha…
Revadi G, Johann Aibantyllilang Blah, Manoj Verma, Arun M Kokane
**INTRODUCTION:** Latent Tuberculosis infection (LTBI) care cascade involves identification of high-risk individuals, testing, identification of LTBI, initiation of Tuberculosis Preventive therapy (TPT) and documentation of outcomes. There is a dearth of such evidence in Indian s…
Sanghmitra Singh, Geetu Singh, Himalaya Singh, Gajendra Vikram Singh
Introduction: Tuberculosis (TB) remains a significant global health challenge, with India bearing the highest burden. Tuberculosis Preventive Therapy (TPT) is a critical strategy to prevent latent TB infection (LTBI) from progressing to active disease, particularly among househol…
Hanthamrongwit J, Aruvornlop P, Saelee C, Wanta N, Poneksawat P, et al.
Multi-stage tuberculosis (TB) vaccines composed of active- and dormancy-associated antigens are promising to trigger the immune protection against all TB stages. However, scientists are still in quest of the suitable vaccine candidates. In this study, we identified the potential …
Fengjuan Wang, Lei Zhou, Xiaoyan Hao, Jiayun Liu
…pathogens and is a contributing factor to the occurrence of tuberculosis infection. The primary objective of this investigation was to examine the risk factors for the progression from latent tuberculosis infection (LTBI) to active tuberculosis (ATB) in patients with rheumatic di…
Qiu B, Liu Q, Li Z, Song H, Xu D, et al.
…ents, a sensitive and specific method to distinguish active tuberculosis from latent tuberculosis infection (LTBI) would allow for early diagnosis and limit the spread of the pathogen. The analysis of multiple cytokine profiles provides the possibility to differentiate the two di…
Sun T, Wu B, Wang J, Yuan T, Huang H, et al.
…is important to distinguish those with active Mycobacterium tuberculosis infection (ATB) from latent tuberculosis infection (LTBI) for monitoring and treating the disease. Monocytes play an important role and may undergo morphological changes against active TB infection. The aim …
Rebeiro PF, Cohen MJ, Ewing HM, Figueiredo MC, Peetluk LS, et al.
Background Tuberculosis (TB) elimination requires treatment of millions of persons with latent M. tuberculosis infection (LTBI). LTBI treatment acceptance depends on population-wide TB knowledge and low stigma, but limited data are available on the relationship between stigma and…
Sofia Kostoudi, Robert Hammond
ABSTRACT Background Tuberculosis (TB) is the second leading infectious killer after COVID-19 and the 13 th leading cause of death worldwide. Latent tuberculosis (LTBI) has become a major pool of potential active tuberculosis cases and is propelling the TB global health burden fur…
Collin R. Diedrich, Tara Rutledge, Pauline Maiello, Tonilynn Baranowski, Alexander G. White, et al.
…nfection is the most common risk factor for severe forms of tuberculosis (TB), regardless of CD4 T cell count. Using a well-characterized cynomolgus macaque model of human TB, we compared radiographic, immunologic and microbiologic characteristics of early (subclinical) reactivat…
Meier NR, Battegay M, Ottenhoff THM, Furrer H, Nemeth J, et al.
…In individuals living with HIV infection the development of tuberculosis (TB) is associated with rapid progression from asymptomatic TB infection to active TB disease. Sputum-based diagnostic tests for TB have low sensitivity in minimal and subclinical TB precluding early diagnos…
Seers T, Quah H, Ludwig D, Noursadeghi M, Brown M, et al.
…ing for an aetiology. Despite previous treatment for latent tuberculosis, he developed changes typical for miliary tuberculosis and was started on antituberculosis therapy; whole genome sequencing later demonstrated isoniazid monoresistance. This case demonstrates both the import…
Aravindhan V, Yuvaraj S
Tuberculosis patients with diabetes, have higher sputum bacillary load, delayed sputum conversion, higher rates of drug resistance, higher lung cavitary involvement and extra-pulmonary TB infection, which is called as "Diabetes-Tuberculosis Nexus". However, recently we have shown…